Association of fasting plasma glucose change trajectory and risk of hypertension: a retrospective cohort in China

in Endocrine Connections
View More View Less
  • 1 Y Lou, Department of Health Management, Beijing Xiaotangshan Hospital, Beijing, China
  • | 2 Y Zhang, Department of Biostatistics and Epidemiology, School of Public Health, Shenzhen University Health Science Center, Shenzhen, China
  • | 3 P Zhao, Department of Health Management, Beijing Xiaotangshan Hospital, Beijing, China
  • | 4 P Qin, Department of Biostatistics and Epidemiology, School of Public Health , Shenzhen University Health Science Center, Shenzhen, China
  • | 5 C Wang, Department of Non-communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, China
  • | 6 J Ma, Department of Non-communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, China
  • | 7 X Peng, Department of Non-communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, China
  • | 8 H Chen, Department of Non-communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, China
  • | 9 D Zhao, Department of Non-communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, China
  • | 10 S Xu, Department of Non-communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, China
  • | 11 L Wang, Department of Non-communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, China
  • | 12 M Zhang, Department of Biostatistics and Epidemiology, School of Public Health, Shenzhen University Health Science Center, Shenzhen University Health Science Center, Shenzhen, China
  • | 13 D Hu, Department of Biostatistics and Epidemiology, School of Public Health, Shenzhen University Health Science Centerι, Shenzhen University Health Science Center, Shenzhen, China
  • | 14 F Hu, Department of Biostatistics and Epidemiology, School of Public Health, Shenzhen University Health Science Center, Shenzhen, China

Correspondence: Fulan Hu, Email: hufulan@szu.edu.cn
Open access

To assess the association between fasting plasma glucose (FPG) change trajectory and incident hypertension among Chinese people, this cohort study included 11,791 adults aged 18 to 80 years without hypertension at first entry and who completed at least four follow-ups between 2009 and 2016. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between FPG change trajectory and probability of hypertension. During a median follow-up of 5.10 years (total person-years 61,887.76), hypertension developed in 2177 participants. After adjusting for baseline potential confounders, the probability of hypertension increased with the increasing FPG change trajectory (adjusted OR [aOR] 1.22, 95% CI 1.07-1.40), bell-shape trajectory (aOR 1.15, 95% CI 1.02-1.30) and other-shape trajectory (aOR 1.13, 95% CI 1.02-1.25) which showed a higher variability of FPG compared to the decreasing group. In addition, the increasing FPG change trajectory was associated with a higher probability of hypertension compared with the decreasing group regardless of age and body mass index (BMI) but was only significant in males and in those with normal FPG at baseline. Our study indicates that the increasing FPG change trajectory determines the highest risk of hypertension, demonstrating the importance of maintaining low and stable levels of FPG, especially in males and in those with normal FPG.

 

     European Society of Endocrinology logo

     Society for Endocrinology logo