Clinical features and outcomes of adrenal schwannoma: a study of 13 cases from a single center

in Endocrine Connections
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  • 1 H Huang, Department of urology, Wuzhou GongRen Hospital, Wuzhou, China
  • 2 Q Ding, Department of urology, The First Affiliated Hospital of GuangXi Medical University, Nanning, China
  • 3 X Lin, Department of urology, Wuzhou GongRen Hospital, Wuzhou, China
  • 4 D Li, Department of Urology, Wuzhou GongRen Hospital, Wuzhou, China
  • 5 J Zeng, Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
  • 6 W Fu, Department of Urology, The First Affiliated Hospital of GuangXi Medical University,, nanning, 530022, China

Correspondence: Weijin Fu, Email:

Background: Adrenal schwannomas (AS) are extremely rare neoplasms. This study shares our experience regarding the diagnosis and operative management of AS.

Methods: Clinical details, radiologic, laboratory, and pathologic findings as well as follow-up data were analyzed retrospectively for 13 AS patients who accepted surgery at a tertiary referral hospital in China between January 1, 1996, and December 31, 2017.

Results: The mean age of the patients at diagnosis was 44.7 ± 13.7 years (range 19–62 years; male: female ratio, 1:1.16), of whom 7 patients had unilateral AS on the right side, and the remaining 6 on the left side. None of the cases were hormonally active. None of the 13 cases were diagnosed as AS by computed tomography imaging before the operation. Among the patients, 10 were asymptomatic. The mean preoperative size was 7.1 ± 3.2 cm (range 1.6–12.6 cm). All patients underwent surgery, with open adrenalectomy in 5 patients and laparoscopy in 8 patients. The mean tumor size on pathologic examination was 6.8 ± 3.0 cm (range 3.0–11.7 cm). The surgical specimens were confirmed by pathological examination. During a median follow-up of 60.8 ± 17.7 months, no patients showed recurrence or metastasis.

Conclusion: The preoperative diagnosis of AS remains difficult despite the advances in imaging examinations. After complete resection, the prognosis of AS is excellent.


     European Society of Endocrinology

     Society for Endocrinology

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