Higher blood pressure in normal weight women with PCOS compared to controls

in Endocrine Connections
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  • 1 J Mellembakken, Department of Reproductive Medicine, Division of Gynecology and Obstetrics, Oslo University Hospital, Oslo, Norway
  • 2 A Mahmoudan, Department of Reproductive Medicine, Division of Gynecology and Obstetrics, Oslo University Hospital, Oslo, Norway
  • 3 L Mørkrid, Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway
  • 4 I Sundström-Poromaa, Department of women's and children's health, Uppsala University, Uppsala, 751 85 , Sweden
  • 5 L Morin-Papunen, Department of Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland
  • 6 J Tapanainen, Department of Obstetrics and Gynecology and, Medical Research Centre Oulu and PEDEGO Research Unit, University Hospital of Oulu, University of Oulu, Oulu, Finland
  • 7 T Piltonen, Department of Obstetrics and Gynecology and Medical Research Centre Oulu and PEDEGO Research Unit, Oulu University Hospital, Oulu, Finland
  • 8 A Hirschberg, Department of Women’s and Children’s Health, Karolinska Institute, Stockholm, Sweden
  • 9 E Stener-Victorin, Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden
  • 10 E Vanky, Department of Obstetrics and Gynecology, Department of Women’s and Childrens Health, Norwegian University of Technology and Science, Trondheim, United Kingdom of Great Britain and Northern Ireland
  • 11 P Ravn, Department of Gynecology and Obstetrics, Odense University Hospital, Odense, Denmark
  • 12 R Jensen, Department of Endocrinology, Odense University Hospital, Odense, Denmark
  • 13 M Andersen, Department of Endocrinology, Odense University Hospital, Odense, Denmark
  • 14 D Glintborg, Department of Endocrinology, Odense University Hospital, Odense, Denmark

Correspondence: Dorte Glintborg, Email: dorte.glintborg@rsyd.dk

Abstract

Objective: Obesity is considered to be the strongest predictive factor for cardio-metabolic risk in women with polycystic ovary syndrome (PCOS). The aim of the study was to compare blood pressure (BP) in normal weight women with PCOS and controls matched for age and BMI?

Methods: From a Nordic cross-sectional base of 2,615 individuals of Nordic ethnicity, we studied a sub cohort of 793 normal weight women with BMI<25 kg/m2 (512 women with PCOS according to Rotterdam criteria and 281 age and BMI-matched controls). Participants underwent measurements of BP and body composition (BMI, waist-hip ratio), lipid status, and fasting BG. Data were presented as median (quartiles).

Results: The median age for women with PCOS were 28 (25; 32) years, and median BMI was 22.2 (20.7; 23.4) kg/m2. Systolic BP was 118 (109; 128) mmHg in women with PCOS compared to 110 (105; 120) mmHg in controls, and diastolic BP was 74 (67; 81) vs. 70 (64; 75) mmHg, both p<0.001. The prevalence of women with BP ≥140/90 mmHg was 11.1% (57/512) in women with PCOS vs. 1.8% (5/281) in controls, p<0.001. In women ≥ 35 years the prevalence of BP ≥140/90 mmHg was comparable in women with PCOS and controls (12.7% vs. 9.8%, p=0.6). Using multiple regression analyses, the strongest association with BP was found for waist circumference, fasting BG and total cholesterol in women with PCOS.

Conclusions: Normal weight women with PCOS have higher BP than controls. BP and metabolic screening are relevant also in young normal weight women with PCOS.

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