Astragaloside IV alleviates placental oxidative stress and inflammation in GDM mouse

in Endocrine Connections
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  • 1 L Zhou, Cangzhou Central Hospital, Cangzhou , China
  • 2 R Zhang, Cangzhou Central Hospital, Cangzhou, 061000, China
  • 3 S Yang, Cangzhou Central Hospital, Cangzhou, China
  • 4 Y Zhang, Cangzhou Central Hospital, Cangzhou, China
  • 5 D Shi, Cangzhou Central Hospital, Cangzhou, China

Correspondence: Ruixue Zhang, Email: zhangruixue120@sina.com

Background: Our previous study revealed that astragaloside IV (AS-IV) effectively improved gestational diabetes mellitus (GDM) by reducing hepatic gluconeogenesis. Due to the importance of placental oxidative stress, we further explored the protective role of AS-IV on placental oxidative stress in GDM.

Methods: First, non-pregnant mice were orally administrated with AS-IV to evaluate its safety and effect. Then GDM mice were orally administered with AS-IV for 20 days and its effect on the symptoms of GDM, placental oxidative stress, secretions of inflammatory cytokines, as well as toll-like receptor 4 (TLR4)/NF-κB signaling pathway, were evaluated.

Results: AS-IV had no adverse effect on non-pregnant mice. On the other hand, AS-IV significantly attenuated the GDM-induced hyperglycemia, glucose intolerance, insulin resistance, placental oxidative stress, productions of inflammatory cytokines and the activation of TLR4/NF-κB pathway.

Conclusion: AS-IV effectively protected against GDM by alleviating placental oxidative stress and inflammation, in which TLR4/NF-κB might be involved.

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     European Society of Endocrinology

     Society for Endocrinology

Sept 2018 onwards Past Year Past 30 Days
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