The impact of endocrine disruptor chemicals on oocyte/embryo and clinical outcomes in IVF

in Endocrine Connections
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  • 1 R Cabry, Amiens University, Amiens, France
  • 2 P Merviel, Brest University, Brest, France
  • 3 A Madkour, Reproductive Medicine , Mohammed V University of Rabat, Rabat, Morocco
  • 4 E Lefranc, Amiens University, Amiens, France
  • 5 F Scheffler, Amiens University, Amiens, France
  • 6 R Desailloud, Amiens University, Amiens, France
  • 7 V Bach, Amiens University, Amiens, France
  • 8 M Benkhalifa, IVF Dept, Amiens University, Amiens, France

Correspondence: Moncef Benkhalifa, Email:

The negative impact of endocrine-disrupting pesticides on human fertility is now a key issue in reproductive health. There are much fewer literature data about the impact of pesticide exposure on women than on men, and very few studies of women participating in an in vitro fertilization (IVF) programme. In the present review, we found that (i) various pesticides with an endocrine-disrupting action are associated with poor oocyte maturation and competency, embryonic defects, and poor IVF outcomes, and (ii) some pesticide compounds are linked to specific causes of female infertility, such as premature ovarian insufficiency, polycystic ovarian syndrome, and endometriosis. IVF participants living in agricultural regions should be informed about the fertility decline, low ongoing pregnancy rates and elevated risk of miscarriage associated with exposure to high doses of pesticides.

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