Immunotherapy failure in adrenocortical cancer: where next?

in Endocrine Connections
Correspondence: Alfredo Berruti, Email:

Excerpt: Adrenocortical carcinoma (ACC) is a rare endocrine neoplasia, characterized by an overall dismal

prognosis and its clinical manifestations are the consequence of either steroid excess or tumor mass

progression. Surgery is the mainstay of therapy. For patients with locally advanced or metastatic

ACC, not amenable to surgery, Mitotane and cytotoxic chemotherapy (with etoposide, doxorubicin

and cisplatin – EDP scheme) are the systemic treatments currently in use


An official journal of

European Society of Endocrinology Society for Endocrinology