Ayana Suzuki
Ayana Suzuki
Department of Diagnostic Pathology and Cytology, Kuma Hospital, Kobe, Japan
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Mitsuyoshi Hirokawa
Mitsuyoshi Hirokawa
Department of Diagnostic Pathology and Cytology, Kuma Hospital, Kobe, Japan
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Izumi Otsuka
Izumi Otsuka
Secretary Section, Kuma Hospital, Kobe, Japan
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Akihiro Miya
Akihiro Miya
Department of Surgery, Kuma Hospital, Kobe, Japan
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Akira Miyauchi
Akira Miyauchi
Department of Surgery, Kuma Hospital, Kobe, Japan
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Takashi Akamizu
Takashi Akamizu
Department of Internal Medicine, Kuma Hospital, Kobe, Japan
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length of the whole tumor and the solid area in three directions on ultrasound images using the formula ( Fig. 1 ). Whole tumor diameter (WTD; Fig. 1D ) and solid area diameter (SAD; Fig. 1A ) were defined as the maximum diameter in the three
Keiko Ohkuwa
Keiko Ohkuwa
Department of Surgery, Ito Hospital, Tokyo, Japan
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Kiminori Sugino
Kiminori Sugino
Department of Surgery, Ito Hospital, Tokyo, Japan
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Mitsuji Nagahama
Mitsuji Nagahama
Department of Surgery, Ito Hospital, Tokyo, Japan
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Wataru Kitagawa
Wataru Kitagawa
Department of Surgery, Ito Hospital, Tokyo, Japan
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Kenichi Matsuzu
Kenichi Matsuzu
Department of Surgery, Ito Hospital, Tokyo, Japan
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Akifumi Suzuki
Akifumi Suzuki
Department of Surgery, Ito Hospital, Tokyo, Japan
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Chisato Tomoda
Chisato Tomoda
Department of Surgery, Ito Hospital, Tokyo, Japan
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Kiyomi Hames
Kiyomi Hames
Department of Surgery, Ito Hospital, Tokyo, Japan
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Junko Akaishi
Junko Akaishi
Department of Surgery, Ito Hospital, Tokyo, Japan
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Chie Masaki
Chie Masaki
Department of Surgery, Ito Hospital, Tokyo, Japan
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Koichi Ito
Koichi Ito
Department of Surgery, Ito Hospital, Tokyo, Japan
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follows: (i) no accumulation of RAI, (ii) tumor growth even with little accumulation of RAI, and (iii) tumor growth after RAI therapy (≥ 600 mCi). Based on the American Thyroid Association Guidelines, 18F-fluorodeoxyglucose PET/CT (18FDG-PET/CT), whole
Reem Al Argan
Reem Al Argan
Endocrine Section, Department of Internal Medicine, College of Medicine, Imam Abdulrahman Bin Faisal University, King Fahd Hospital of the University, Khobar, Eastern Province, Saudi Arabia
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Abdulaziz Ramadhan
Abdulaziz Ramadhan
Division of Endocrinology and Metabolism, Department of Medicine, McGill University Health Center, Montreal, Quebec, Canada
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Ramanakumar V Agnihotram
Ramanakumar V Agnihotram
Statistician, Research Institute-McGill University Health Center, Montreal, Quebec, Canada
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Jeffrey Chankowsky
Jeffrey Chankowsky
Department of Diagnostic Radiology, McGill University Health Center, Montreal, Quebec, Canada
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Juan Rivera
Juan Rivera
Division of Endocrinology and Metabolism, Department of Medicine, McGill University Health Center, Montreal, Quebec, Canada
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). In regards to tumor size, various tumor diameter cut-off has been proposed as predictors of specific pituitary hormone deficiencies ( 16 ). The current report presents our findings in a group of unselected patients with NFPA. We aim to establish
Xinlei Chen
Xinlei Chen
Department of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu, Sichuan, China
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Liru Hu
Liru Hu
Department of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu, Sichuan, China
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Caojie Liu
Caojie Liu
Department of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu, Sichuan, China
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Guangcheng Ni
Guangcheng Ni
Department of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu, Sichuan, China
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Yuwei Zhang
Yuwei Zhang
Department of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu, Sichuan, China
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was 5.7 years, with a median of 1.0 years (range: 0.05–30 years). All patients’ diagnoses were confirmed through postoperative histological examination by experienced pathologists. Average tumor diameter was 4.9 ± 2.3 cm and 370 of the tumors (70
M Ingenwerth
M Ingenwerth
Institute of Pathology, University Hospital of Essen, University of Duisburg–Essen, Essen, Germany
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T Brandenburg
T Brandenburg
Division of Laboratory Research, Department of Endocrinology, Diabetes and Metabolism and Clinical Chemistry, University Hospital Essen, University of Duisburg-Essen, Germany
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D Führer-Sakel
D Führer-Sakel
Division of Laboratory Research, Department of Endocrinology, Diabetes and Metabolism and Clinical Chemistry, University Hospital Essen, University of Duisburg-Essen, Germany
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M Goetz
M Goetz
Institute of Pathology, University Hospital of Essen, University of Duisburg–Essen, Essen, Germany
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F Weber
F Weber
Department of General, Visceral and Transplantation Surgery, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
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H Dralle
H Dralle
Department of General, Visceral and Transplantation Surgery, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
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H-U Schildhaus
H-U Schildhaus
Institute of Pathology, University Hospital of Essen, University of Duisburg–Essen, Essen, Germany
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K W Schmid
K W Schmid
Institute of Pathology, University Hospital of Essen, University of Duisburg–Essen, Essen, Germany
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S Theurer
S Theurer
Institute of Pathology, University Hospital of Essen, University of Duisburg–Essen, Essen, Germany
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slide and corresponding core biopsies of 2 mm diameter were taken in triplicates with a TMA Grand Master System (3DHistech, Hungary) according to the manufacturer’s protocol. 10 cases were left out for whole slide stains to assess distribution of
Logan Mills
Logan Mills
Institute of Liver Studies, King’s College Hospital, London, UK
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Panagiotis Drymousis
Panagiotis Drymousis
Department of Surgery and Cancer, Imperial College, London, UK
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Yogesh Vashist
Yogesh Vashist
Department of General, Visceral and Thoracic Surgery, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany
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Christoph Burdelski
Christoph Burdelski
Department of General, Visceral and Thoracic Surgery, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany
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Andreas Prachalias
Andreas Prachalias
Department of Surgery, King’s College Hospital, London, UK
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Parthi Srinivasan
Parthi Srinivasan
Department of Surgery, King’s College Hospital, London, UK
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Krishna Menon
Krishna Menon
Department of Surgery, King’s College Hospital, London, UK
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Corina Cotoi
Corina Cotoi
Department of Histopathology, King’s College Hospital, London, UK
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Saboor Khan
Saboor Khan
Department of Surgery, University Hospitals Coventry and Warwickshire, Coventry, UK
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Judith Cave
Judith Cave
Department of Oncology, University Hospital, Southampton, UK
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Thomas Armstrong
Thomas Armstrong
Department of Surgery, University Hospital, Southampton, UK
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Martin O Weickert
Martin O Weickert
Department of Endocrinology, University Hospitals Coventry and Warwickshire, Coventry, UK
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Jakob Izbicki
Jakob Izbicki
Department of General, Visceral and Thoracic Surgery, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany
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Joerg Schrader
Joerg Schrader
Departments of Gastroenterology and Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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Andreja Frilling
Andreja Frilling
Department of Surgery and Cancer, Imperial College, London, UK
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John K Ramage
John K Ramage
Institute of Liver Studies, King’s College Hospital, London, UK
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Raj Srirajaskanthan
Raj Srirajaskanthan
Institute of Liver Studies, King’s College Hospital, London, UK
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Scientific Ethics Committee (REGO-2015-1675). Data collection Patient notes were reviewed for relevant variables, and data were collated between centres using a standardised Microsoft Access v16 database. Tumour diameter, morphology and
Stefan M Constantinescu
Stefan M Constantinescu
Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Brussels, Belgium
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Thierry Duprez
Thierry Duprez
Department of Radiology, Cliniques Universitaires Saint-Luc, Brussels, Belgium
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Edward Fomekong
Edward Fomekong
Department of Neurosurgery, Cliniques Universitaires Saint-Luc, Brussels, Belgium
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Christian Raftopoulos
Christian Raftopoulos
Department of Neurosurgery, Cliniques Universitaires Saint-Luc, Brussels, Belgium
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Orsalia Alexopoulou
Orsalia Alexopoulou
Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Brussels, Belgium
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Dominique Maiter
Dominique Maiter
Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Brussels, Belgium
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defects in eight out of the 36 patients with chiasmal contact of the tumor. Of note, only one of the eight patients had subjective perception of the defect. Twenty-four (37%) patients complained of headache. The mean maximal tumor diameter was 20.0 ± 7
Jing Zhang
Jing Zhang
Department of Radiology, Lanzhou University Second Hospital, Lanzhou, China
Key Laboratory of Medical Imaging of Gansu Province, Lanzhou, China
Second Clinical School, Lanzhou University, Lanzhou, China
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Key Laboratory of Medical Imaging of Gansu Province, Lanzhou, China
Second Clinical School, Lanzhou University, Lanzhou, China
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Zhiyong Zhao
Zhiyong Zhao
Department of Radiology, Lanzhou University Second Hospital, Lanzhou, China
Key Laboratory of Medical Imaging of Gansu Province, Lanzhou, China
Second Clinical School, Lanzhou University, Lanzhou, China
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Key Laboratory of Medical Imaging of Gansu Province, Lanzhou, China
Second Clinical School, Lanzhou University, Lanzhou, China
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Li Dong
Li Dong
Department of Pathology, Lanzhou University Second Hospital, Lanzhou, China
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Tao Han
Tao Han
Department of Radiology, Lanzhou University Second Hospital, Lanzhou, China
Key Laboratory of Medical Imaging of Gansu Province, Lanzhou, China
Second Clinical School, Lanzhou University, Lanzhou, China
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Key Laboratory of Medical Imaging of Gansu Province, Lanzhou, China
Second Clinical School, Lanzhou University, Lanzhou, China
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Guojin Zhang
Guojin Zhang
Department of Radiology, Lanzhou University Second Hospital, Lanzhou, China
Key Laboratory of Medical Imaging of Gansu Province, Lanzhou, China
Second Clinical School, Lanzhou University, Lanzhou, China
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Key Laboratory of Medical Imaging of Gansu Province, Lanzhou, China
Second Clinical School, Lanzhou University, Lanzhou, China
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Yuntai Cao
Yuntai Cao
Department of Radiology, Lanzhou University Second Hospital, Lanzhou, China
Key Laboratory of Medical Imaging of Gansu Province, Lanzhou, China
Second Clinical School, Lanzhou University, Lanzhou, China
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Key Laboratory of Medical Imaging of Gansu Province, Lanzhou, China
Second Clinical School, Lanzhou University, Lanzhou, China
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Junlin Zhou
Junlin Zhou
Department of Radiology, Lanzhou University Second Hospital, Lanzhou, China
Key Laboratory of Medical Imaging of Gansu Province, Lanzhou, China
Second Clinical School, Lanzhou University, Lanzhou, China
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Key Laboratory of Medical Imaging of Gansu Province, Lanzhou, China
Second Clinical School, Lanzhou University, Lanzhou, China
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adenomas account for 14–54% of pituitary adenomas and lack biochemical evidence of hormone secretion ( 4 ). Tumors with a diameter of greater than or equal to 10 mm are considered macroadenomas ( 2 ). In contrast, sellar meningiomas arise from adjacent
Shan Wu
Shan Wu
College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang, People’s Republic of China
Research Center for Translational Medicine, Cancer Stem Cell Institute, East Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China
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Research Center for Translational Medicine, Cancer Stem Cell Institute, East Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China
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Jianjun Zhou
Jianjun Zhou
Research Center for Translational Medicine, Cancer Stem Cell Institute, East Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China
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Jing Guo
Jing Guo
Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, People’s Republic of China
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Zhan Hua
Zhan Hua
Department of General Surgery, China-Japan Friendship Hospital, Beijing, People’s Republic of China
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Jianchen Li
Jianchen Li
College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang, People’s Republic of China
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Zai Wang
Zai Wang
Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, People’s Republic of China
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of the back. Tumor growth was evaluated every other day by measuring of the tumor diameter (mm) along the largest ( a ) and perpendicular ( b ) axes, from which the tumor volume ( V ; mm 3 ) was calculated according to the formula: V = 0.5 × a
Solène Castellnou
Solène Castellnou
Service d’Endocrinologie, Centre de Référence des Maladies Rares de l’Hypophyse HYPO, Groupement Hospitalier Est, Hospices Civils de Lyon, Bron, France
Université Lyon 1, Villeurbanne, France
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Université Lyon 1, Villeurbanne, France
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Alexandre Vasiljevic
Alexandre Vasiljevic
Université Lyon 1, Villeurbanne, France
Centre de Biologie et Pathologie Est, Groupement Hospitalier Est, Hospices Civils de Lyon, Bron, France
INSERM U1052, CNRS, UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France
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Centre de Biologie et Pathologie Est, Groupement Hospitalier Est, Hospices Civils de Lyon, Bron, France
INSERM U1052, CNRS, UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France
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Véronique Lapras
Véronique Lapras
Service de Radiologie, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Pierre-Bénite, France
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Véronique Raverot
Véronique Raverot
Laboratoire d’Hormonologie, Centre de Biologie et Pathologie Est, Groupement Hospitalier Est, Hospices Civils de Lyon, Bron, France
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Eudeline Alix
Eudeline Alix
Département de Cytogénétique, Centre de Biologie et Pathologie Est, Groupement Hospitalier Est, Hospices Civils de Lyon, Bron, France
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Françoise Borson-Chazot
Françoise Borson-Chazot
Service d’Endocrinologie, Centre de Référence des Maladies Rares de l’Hypophyse HYPO, Groupement Hospitalier Est, Hospices Civils de Lyon, Bron, France
Université Lyon 1, Villeurbanne, France
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Université Lyon 1, Villeurbanne, France
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Emmanuel Jouanneau
Emmanuel Jouanneau
Université Lyon 1, Villeurbanne, France
INSERM U1052, CNRS, UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France
Service de Neurochirurgie, Groupement Hospitalier Est, Hospices Civils de Lyon, Bron, France
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INSERM U1052, CNRS, UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France
Service de Neurochirurgie, Groupement Hospitalier Est, Hospices Civils de Lyon, Bron, France
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Gérald Raverot
Gérald Raverot
Service d’Endocrinologie, Centre de Référence des Maladies Rares de l’Hypophyse HYPO, Groupement Hospitalier Est, Hospices Civils de Lyon, Bron, France
Université Lyon 1, Villeurbanne, France
INSERM U1052, CNRS, UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France
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Université Lyon 1, Villeurbanne, France
INSERM U1052, CNRS, UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France
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Hélène Lasolle
Hélène Lasolle
Service d’Endocrinologie, Centre de Référence des Maladies Rares de l’Hypophyse HYPO, Groupement Hospitalier Est, Hospices Civils de Lyon, Bron, France
Université Lyon 1, Villeurbanne, France
INSERM U1052, CNRS, UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France
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Université Lyon 1, Villeurbanne, France
INSERM U1052, CNRS, UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France
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clinical or biochemical signs of Cushing’s disease were present prior to surgery. Preoperative MRI were reviewed by a pituitary specialist radiologist (V L), and the tumor size, defined as the largest diameter observed on MRI, and cavernous sinus invasion
