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Karolien Van De Maele Division of Pediatric Endocrinology, KidZ Health Castle, UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium

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Jean De Schepper Division of Pediatric Endocrinology, KidZ Health Castle, UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium

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Jesse Vanbesien Division of Pediatric Endocrinology, KidZ Health Castle, UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium

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Monique Van Helvoirt Zeepreventorium, De Haan, Belgium

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Ann De Guchtenaere Zeepreventorium, De Haan, Belgium

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Inge Gies Division of Pediatric Endocrinology, KidZ Health Castle, UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium

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25-OH vitamin D level after obtaining weight loss ( 16 , 17 ). However, the possible causal nature of the correlation between body fat loss and increased serum 25 OH vitamin D level remains controversial. Both obesity and vitamin D deficiency are

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0364
Volume/Issue:
Volume 8: Issue 11
Open access
Thomas Reinehr Department of Pediatric Endocrinology, Diabetes, and Nutrition Medicine, Vestische Hospital for Children and Adolescents, University of Witten/Herdecke, Datteln, Germany

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Alexandra Kulle Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, University Hospital of Schleswig – Holstein, UKSH, Campus Kiel/Christian Albrechts University of Kiel, CAU, Kiel, Germany

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Juliane Rothermel Department of Pediatric Endocrinology, Diabetes, and Nutrition Medicine, Vestische Hospital for Children and Adolescents, University of Witten/Herdecke, Datteln, Germany

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Caroline Knop-Schmenn Department of Pediatric Endocrinology, Diabetes, and Nutrition Medicine, Vestische Hospital for Children and Adolescents, University of Witten/Herdecke, Datteln, Germany

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Nina Lass Department of Pediatric Endocrinology, Diabetes, and Nutrition Medicine, Vestische Hospital for Children and Adolescents, University of Witten/Herdecke, Datteln, Germany

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Christina Bosse Department of Pediatric Endocrinology, Diabetes, and Nutrition Medicine, Vestische Hospital for Children and Adolescents, University of Witten/Herdecke, Datteln, Germany

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Paul-Martin Holterhus Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, University Hospital of Schleswig – Holstein, UKSH, Campus Kiel/Christian Albrechts University of Kiel, CAU, Kiel, Germany

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primary outcome was the comparison calculated by Kruskal–Wallis test of the changes of four key steroid hormones in the four groups: (1) no PCOS and no weight loss, (2) PCOS and no weight loss, (3) no PCOS and weight loss and (4) PCOS and weight loss

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-17-0051
Volume/Issue:
Volume 6: Issue 4
Open access
Monika Karczewska-Kupczewska Department of Internal Medicine and Metabolic Diseases, Medical University of Białystok, Białystok, Poland

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Agnieszka Nikołajuk Department of Prophylaxis of Metabolic Diseases, Institute of Animal Reproduction and Food Research Polish Academy of Sciences, Olsztyn, Poland

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Radosław Majewski Department of Prophylaxis of Metabolic Diseases, Institute of Animal Reproduction and Food Research Polish Academy of Sciences, Olsztyn, Poland

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Remigiusz Filarski Department of Prophylaxis of Metabolic Diseases, Institute of Animal Reproduction and Food Research Polish Academy of Sciences, Olsztyn, Poland

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Magdalena Stefanowicz Department of Metabolic Diseases, Medical University of Białystok, Białystok, Poland

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Natalia Matulewicz Department of Metabolic Diseases, Medical University of Białystok, Białystok, Poland

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Marek Strączkowski Department of Prophylaxis of Metabolic Diseases, Institute of Animal Reproduction and Food Research Polish Academy of Sciences, Olsztyn, Poland

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study groups and different clinical situations. Thus, there is need for further studies on the association between AT lipases and insulin sensitivity in different conditions/interventions in humans. Weight loss is an effective tool to prevent obesity

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0507
Volume/Issue:
Volume 9: Issue 2
Open access
Thomas Reinehr Department of Pediatric Endocrinology, Diabetes and Nutrition Medicine, Vestische Hospital for Children and Adolescents Datteln, University of Witten/Herdecke, Witten, Germany

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Alberto Sánchez-Guijo Steroid Research & Mass Spectrometry Unit, Division of Pediatric Endocrinology and Diabetology, Center of Child and Adolescent Medicine, Justus-Liebig-University Giessen, Giessen, Germany

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Nina Lass Department of Pediatric Endocrinology, Diabetes and Nutrition Medicine, Vestische Hospital for Children and Adolescents Datteln, University of Witten/Herdecke, Witten, Germany

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Stefan A Wudy Steroid Research & Mass Spectrometry Unit, Division of Pediatric Endocrinology and Diabetology, Center of Child and Adolescent Medicine, Justus-Liebig-University Giessen, Giessen, Germany

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concentrations are linked with weight status in obese children since substantial weight loss in obese children is associated with variations of unconjugated steroids like androgens and corticoids ( 1 , 2 , 6 ). In addition, we analyzed whether cardiovascular

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0233
Volume/Issue:
Volume 7: Issue 10
Open access
Magnolia Ariza-Nieto Cornell University, Meinig School of Biomedical Engineering, Ithaca, New York, USA
epiWELL, LLC, Ithaca, New York, USA

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Joshua B Alley Donald Guthrie Foundation for Education and Research, Guthrie Clinic, Sayre, Pennsylvania, USA

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Sanjay Samy Donald Guthrie Foundation for Education and Research, Guthrie Clinic, Sayre, Pennsylvania, USA

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Laura Fitzgerald Donald Guthrie Foundation for Education and Research, Guthrie Clinic, Sayre, Pennsylvania, USA

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Francoise Vermeylen Cornell University, Cornell Statistical Consulting Unit, Ithaca, New York, USA

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Michael L Shuler Cornell University, Meinig School of Biomedical Engineering, Ithaca, New York, USA

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José O Alemán New York University Langone Medical Center, New York, New York, USA

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, 19 ). We report that high levels of MIR148A in plasma and low levels in liver DNMT1 mRNA transcripts in liver are related to adiponectin insensitivity in patients following metabolic surgery for weight loss at 12 weeks. Materials and methods

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0205
Volume/Issue:
Volume 7: Issue 9
Open access
Julia Otten Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden

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Andreas Stomby Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden
Region Jönköping County, Jönköping, Sweden

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Maria Waling Department of Food, Nutrition and Culinary Science, Umeå University, Umeå, Sweden

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Elin Chorell Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden

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Mats Ryberg Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden

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Michael Svensson Department of Community Medicine and Rehabilitation, Section for Sports Medicine, Umeå University, Umeå Sweden

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Jens Juul Holst NNF Center for Basic Metabolic Research and Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark

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Tommy Olsson Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden

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, rather than glutamine, would be a predominant stimulator of glucagon secretion in patients with type 2 diabetes. It is well established that diet-induced weight loss improves hepatic insulin sensitivity in individuals with type 2 diabetes ( 13 ). However

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-21-0171
Volume/Issue:
Volume 10: Issue 9
Open access
Alexis Sudlow Department of Upper GI Surgery, Southmead Hospital, Bristol, UK

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Carel W le Roux Department of Experimental Pathology, University College Dublin, Dublin, Ireland

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Dimitri J Pournaras Department of Upper GI Surgery, Southmead Hospital, Bristol, UK

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Introduction The early concept of surgical intervention to mediate weight loss in patients suffering from obesity stemmed from the observation of the substantial and often problematic weight loss following gastrointestinal surgery for cancer

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-19-0467
Volume/Issue:
Volume 9: Issue 2
Open access
Helle Keinicke Insulin and Device Trial Operations, Novo Nordisk A/S, Søborg, Denmark

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Gao Sun Pharmacology and Histopathology, Novo Nordisk A/S, China

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Caroline M Junker Mentzel Department of Experimental Animal Models, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg C, Denmark

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Merete Fredholm Department of Veterinary Clinical and Animal Science, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg C, Denmark

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Linu Mary John Global Obesity and Liver Disease Research, Novo Nordisk A/S, Måløv, Denmark

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Birgitte Andersen Global Obesity and Liver Disease Research, Novo Nordisk A/S, Måløv, Denmark

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Kirsten Raun Global Obesity and Liver Disease Research, Novo Nordisk A/S, Måløv, Denmark

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Marina Kjaergaard Global Obesity and Liver Disease Research, Novo Nordisk A/S, Måløv, Denmark

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approved, but many compounds targeting various pathways are in the clinical pipeline, as reviewed by Rotman & Sanyal ( 7 ). Presently, the most effective method to alleviate NASH is body weight loss ( 4 , 8 ), but to reverse fibrosis a body weight loss of

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-20-0152
Volume/Issue:
Volume 9: Issue 8
Open access
Anru Wang Department of Pediatrics, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Department of Pediatrics, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China

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Xueqin Yan Department of Pediatrics, Boai Hospital of Zhongshan, Zhongshan, China

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Cai Zhang Department of Pediatrics, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Caiqi Du Department of Pediatrics, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Wenjun Long Department of Pediatrics, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Di Zhan Department of Pediatrics, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Xiaoping Luo Department of Pediatrics, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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), fasting glucose and hemoglobin A1c (HbA1c) in T2DM adults ( 8 ). The correlation between FGF1 and other glucose/lipid metabolic variables following weight loss in obese individuals remains unknown. Therefore, in this study, we aimed to investigate the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0141
Volume/Issue:
Volume 7: Issue 8
Open access
Monika Karczewska-Kupczewska Department of Internal Medicine and Metabolic Diseases, Medical University of Białystok, Białystok, Poland

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Agnieszka Nikołajuk Department of Prophylaxis of Metabolic Diseases, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland

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Magdalena Stefanowicz Department of Metabolic Diseases, Medical University of Białystok, Białystok, Poland

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Natalia Matulewicz Department of Metabolic Diseases, Medical University of Białystok, Białystok, Poland

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Irina Kowalska Department of Internal Medicine and Metabolic Diseases, Medical University of Białystok, Białystok, Poland

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Marek Strączkowski Department of Prophylaxis of Metabolic Diseases, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland

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decreased after weight loss induced by bariatric surgery ( 12 , 14 ). Furthermore, positive correlations between serum chemerin and BMI, blood triglyceride level, waist-to-hip ratio and blood pressure, and an inverse correlation with HDL-cholesterol were

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-20-0084
Volume/Issue:
Volume 9: Issue 5
Open access