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Stavroula A Paschou, Nektaria Papadopoulou-Marketou, George P Chrousos and Christina Kanaka-Gantenbein

Introduction Type 1 diabetes mellitus (T1DM) represents only around 10% of the diabetes cases worldwide, but occurs with increasing incidence much earlier in life. T1DM results from the autoimmune destruction of β cells of the endocrine

Open access

A Rouland, J-C Chauvet-Gelinier, A-L Sberna, E Crevisy, P Buffier, T Mouillot, J-M Petit and B Vergès

Introduction Type 1 (T1D) and type 2 diabetes (T2D) are chronic diseases in which psychological determinants are an important field of research, not only to improve personalized treatment and educational strategies, but also to directly

Open access

P R van Dijk, S J J Logtenberg, K H Groenier, N Kleefstra, H J G Bilo and H J Arnqvist

the hepatic sensitivity of GH stimulation and subsequently increases IGF1 production (8) . Furthermore, insulin increases IGF1 bioactivity by a down-regulation of IGFBP1 expression in the liver (5) . In type 1diabetes mellitus (T1DM), with

Open access

Louise Færch, Anders Juul, Ulrik Pedersen-Bjergaard and Birger Thorsteinsson

Introduction GH is part of the second-line counter-regulatory response to hypoglycemia and acts by promoting gluconeogenesis. In long-standing type 1 diabetes with counter-regulatory failure in terms of diminished glucagon and adrenaline responses

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Ozlem Atan Sahin, Damla Goksen, Aysel Ozpinar, Muhittin Serdar and Huseyin Onay

Introduction Type 1 diabetes (DM1) is a complex disease characterized by the autoimmune destruction of pancreatic β cells. Vitamin D is an immune regulatory hormone that exerts its effects through highly polymorphic VDR that belongs to

Open access

Changwei Liu, Jingwen Wang, Yuanyuan Wan, Xiaona Xia, Jian Pan, Wei Gu and Mei Li

Background Type 1 diabetes mellitus (T1DM) is an autoimmune disease occurring in the pancreatic islets. The disease can affect people of any age, but onset usually occurs in children or young adults, which accounts for 90% of diabetes in

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W Liu, Y Wang, X Han, X Cai, Y Zhu, M Zhang, S Gong, J Li and L Ji

Introduction Chronic complications cause the largest proportion of deaths and increase in prevalence with the duration of the disease in long-standing type 1 diabetes (T1DM). ( 1 ) Indeed, the duration of diabetes and severity of hyperglycemia

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Eva O Melin, Jonatan Dereke, Maria Thunander and Magnus Hillman

immune-mediated inflammation in individuals with type 2 diabetes mellitus ( 34 ). If sCD163 is causative in the development of DR, one potential treatment for reducing sCD163 could be a GLP-1 analog, which would be another subject for further research

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Eva Olga Melin, Jonatan Dereke, Maria Thunander and Magnus Hillman

Introduction Depression is associated with type 1 diabetes (T1D), Alzheimer’s disease, increased coronary heart disease and both coronary and all-cause mortality ( 1 , 2 , 3 ). T1D has a serious impact on mental health, indicated by the more

Open access

Lili Liu, Zhuo Shao, Ying Xia, Jiabi Qin, Yang Xiao, Zhiguang Zhou and Zubing Mei

Introduction Type 1 diabetes mellitus (T1DM), which is caused by the selective destruction of the insulin-producing β cells located in the pancreatic islets of Langerhans, is one of the most common and debilitating autoimmune diseases ( 1