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Kjersti S Bakken Women’s Clinic, Innlandet Hospital Trust, Lillehammer, Norway
Center for International Health, University of Bergen, Bergen, Norway

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Kristina Randjelovic Nermo Center for International Health, University of Bergen, Bergen, Norway
Department of Microbiology, Innlandet Hospital Trust, Lillehammer, Norway

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Bjørn Gunnar Nedrebø Department of Medicine, Haugesund Hospital, Haugesund, Norway
Department of Clinical Science, University of Bergen, Bergen, Norway

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Tim I M Korevaar Academic Center for Thyroid Diseases, Erasmus University Medical Center, Rotterdam, the Netherlands

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Tor A Strand Center for International Health, University of Bergen, Bergen, Norway
Department of Research, Innlandet Hospital Trust, Lillehammer, Norway

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screening efforts ( 2 ). It remains unknown if levothyroxine therapy for mild forms of thyroid hypofunction has any beneficial effects. Yet, recent insights have suggested that the definition of thyroid dysfunction in guidelines published before 2017 has

Article Type:
Research Article
Collections:
Thyroid
DOI:
https://doi.org/10.1530/EC-21-0631
Volume/Issue:
Volume 11: Issue 4
Open access
Helle Døssing Department of Oto-rhino-laryngology and Neck Surgery, Odense University Hospital, Odense, Denmark
Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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Finn Noe Bennedbæk Department of Endocrinology and Metabolism, Herlev University Hospital, Herlev, Denmark

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Laszlo Hegedüs Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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this long-term follow-up after LT therapy, for a benign cystic-solid thyroid nodule. Results for patients in the surgery group The decision of subsequent surgery was based on persistent nodule-related compressive symptoms and/or cosmetic

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0236
Volume/Issue:
Volume 8: Issue 7
Open access
Eugenie S Lim Barts Health NHS Trust, Barts and the London School of Medicine and Dentistry, London, UK

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Shanty G Shah Barts and the London School of Medicine and Dentistry, QMUL, London, UK

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Mona Waterhouse Barts Health NHS Trust, Barts and the London School of Medicine and Dentistry, London, UK

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Scott Akker Barts Health NHS Trust, Barts and the London School of Medicine and Dentistry, London, UK
Barts and the London School of Medicine and Dentistry, QMUL, London, UK

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William Drake Barts Health NHS Trust, Barts and the London School of Medicine and Dentistry, London, UK
Barts and the London School of Medicine and Dentistry, QMUL, London, UK

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Nick Plowman Barts Health NHS Trust, Barts and the London School of Medicine and Dentistry, London, UK
Barts and the London School of Medicine and Dentistry, QMUL, London, UK

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Daniel M Berney Barts Health NHS Trust, Barts and the London School of Medicine and Dentistry, London, UK
Barts and the London School of Medicine and Dentistry, QMUL, London, UK

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Polly Richards Barts Health NHS Trust, Barts and the London School of Medicine and Dentistry, London, UK

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Ashok Adams Barts Health NHS Trust, Barts and the London School of Medicine and Dentistry, London, UK

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Ewa Nowosinska Barts Health NHS Trust, Barts and the London School of Medicine and Dentistry, London, UK

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Carmel Brennan Barts Health NHS Trust, Barts and the London School of Medicine and Dentistry, London, UK

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Maralyn Druce Barts Health NHS Trust, Barts and the London School of Medicine and Dentistry, London, UK
Barts and the London School of Medicine and Dentistry, QMUL, London, UK

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intracellular therapy, but concurrent gamma emission detected on post-ablation imaging demonstrates the extent and location of residual thyroid remnant or disease. The exact activity of 131 I required for thyroid remnant ablation has been controversial; for

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0053
Volume/Issue:
Volume 8: Issue 5
Open access
Daniel Alexander Hescheler Department of Nuclear Medicine, University Hospital Münster, Münster, Germany
European Institute for Molecular Imaging (EIMI), University of Münster, Münster, Germany

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Milan Janis Michael Hartmann Department of General, Visceral, Tumor and Transplant Surgery, University Hospital Cologne, Cologne, Germany

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Burkhard Riemann Department of Nuclear Medicine, University Hospital Münster, Münster, Germany

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Maximilian Michel Institute of Zoology, University of Cologne Germany, Cologne, Germany

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Christiane Josephine Bruns Department of General, Visceral, Tumor and Transplant Surgery, University Hospital Cologne, Cologne, Germany

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Hakan Alakus Department of General, Visceral, Tumor and Transplant Surgery, University Hospital Cologne, Cologne, Germany

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Costanza Chiapponi Department of General, Visceral, Tumor and Transplant Surgery, University Hospital Cologne, Cologne, Germany

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( Table 1 ) ( 2 ). Table 1 Overview of clinical trials involving ATC (data from Al-Jundi et al. ( 37 )). The table lists the clinical trials on BRAF/MEK inhibitors, kinase inhibitors, mTOR inhibitors and combination therapies in anaplastic thyroid

Article Type:
Research Article
Collections:
Hormones and Cancer
DOI:
https://doi.org/10.1530/EC-21-0624
Volume/Issue:
Volume 11: Issue 4
Open access
Ulla Schmidt Endocrine Unit, Department of Medicine, Endocrine Unit, Faculty of Health Sciences, Department of Medicine O, Herlev University Hospital, Herlev Ringvej, DK-2730 Herlev, Denmark

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Birte Nygaard Endocrine Unit, Department of Medicine, Endocrine Unit, Faculty of Health Sciences, Department of Medicine O, Herlev University Hospital, Herlev Ringvej, DK-2730 Herlev, Denmark

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Ebbe Winther Jensen Endocrine Unit, Department of Medicine, Endocrine Unit, Faculty of Health Sciences, Department of Medicine O, Herlev University Hospital, Herlev Ringvej, DK-2730 Herlev, Denmark

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Jan Kvetny Endocrine Unit, Department of Medicine, Endocrine Unit, Faculty of Health Sciences, Department of Medicine O, Herlev University Hospital, Herlev Ringvej, DK-2730 Herlev, Denmark

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Anne Jarløv Endocrine Unit, Department of Medicine, Endocrine Unit, Faculty of Health Sciences, Department of Medicine O, Herlev University Hospital, Herlev Ringvej, DK-2730 Herlev, Denmark

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Jens Faber Endocrine Unit, Department of Medicine, Endocrine Unit, Faculty of Health Sciences, Department of Medicine O, Herlev University Hospital, Herlev Ringvej, DK-2730 Herlev, Denmark
Endocrine Unit, Department of Medicine, Endocrine Unit, Faculty of Health Sciences, Department of Medicine O, Herlev University Hospital, Herlev Ringvej, DK-2730 Herlev, Denmark

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Thyroid Association has recently published guidelines concerning T 3 treatment of hypothyroidism and has concluded that T 4 /T 3 combination therapy should be considered in some situations, but as an experimental modality (8) . A recent clinical review

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-12-0064
Volume/Issue:
Volume 2: Issue 1
Open access
John E M Midgley
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Rolf Larisch North Lakes Clinical, Department of Nuclear Medicine, Medical Department I, Ruhr Center for Rare Diseases (CeSER), 20 Wheatley Avenue, Ilkley LS29 8PT, UK

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Johannes W Dietrich North Lakes Clinical, Department of Nuclear Medicine, Medical Department I, Ruhr Center for Rare Diseases (CeSER), 20 Wheatley Avenue, Ilkley LS29 8PT, UK
North Lakes Clinical, Department of Nuclear Medicine, Medical Department I, Ruhr Center for Rare Diseases (CeSER), 20 Wheatley Avenue, Ilkley LS29 8PT, UK

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Rudolf Hoermann North Lakes Clinical, Department of Nuclear Medicine, Medical Department I, Ruhr Center for Rare Diseases (CeSER), 20 Wheatley Avenue, Ilkley LS29 8PT, UK

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ineligible to participate in the study. This exclusion extended to other conditions and the use of comedications that may interfere with the resorption or measurement of thyroid hormones or with pituitary TSH. Patients with T 3 /T 4 combination therapy ( n

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-15-0056
Volume/Issue:
Volume 4: Issue 4
Open access
Xiaoya Zheng Department of Endocrinology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Heng Xiao Department of Hepatobiliary Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Jian Long Department of Endocrinology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Qiang Wei Prevention of Disease Department, Chongqing Jiulongpo District Hospital of Traditional Chinese Medicine, Chongqing, China

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Liping Liu Department of Ultrasound, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Liping Zan Department of Endocrinology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Wei Ren Department of Endocrinology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China

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-related adverse events (irAEs) ( 2 ). Among endocrine irAEs, thyroid dysfunction occurs most frequently in patients treated with anti-PD-1 therapy ( 3 , 4 ). The mechanism by which anti-PD-1 treatment causes abnormal thyroid function is not yet fully understood

Article Type:
Research Article
Collections:
Thyroid
DOI:
https://doi.org/10.1530/EC-22-0065
Volume/Issue:
Volume 11: Issue 5
Open access
Alessandro Brancatella Endocrine Unit 1, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

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Claudio Marcocci Endocrine Unit 2, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

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of treatment is to replace thyroid function but, in the latter condition, an additional aim is to keep the serum thyroid-stimulating hormone (TSH) at the lower limit of the normal range and possibly below (TSH suppressive therapy) to improve the

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-20-0167
Volume/Issue:
Volume 9: Issue 7
Open access
Thera P Links Division of Endocrinology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

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Trynke van der Boom Division of Endocrinology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

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Wouter T Zandee Division of Endocrinology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

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Joop D Lefrandt Division of Vascular Medicine, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

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the impact of overt and subclinical hyperthyroidism on the cardiovascular system. We will thereafter present the latest insights on the cardiac effects of thyroid suppression therapy for the treatment of thyroid cancer. Finally, we will show new

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-20-0539
Volume/Issue:
Volume 10: Issue 1
Open access
Anna Olsson-Brown Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK
The Clatterbridge Cancer Centre, Wirral, UK

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Rosemary Lord The Clatterbridge Cancer Centre, Wirral, UK

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Joseph Sacco The Clatterbridge Cancer Centre, Wirral, UK
Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK

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Jonathan Wagg Roche Innovation Center, Basel, Switzerland

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Mark Coles Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK

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Munir Pirmohamed Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK

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checkpoint blockade with grade 3/4 irAEs occurring in 58–68% of patients ( 1 , 2 ). The incidence of thyroid dysfunction is increased with PD-1 inhibitor therapy when compared with ipilimumab ( 6 , 9 , 10 ). While the majority of irAEs are treatable and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0473
Volume/Issue:
Volume 9: Issue 4
Open access