Aglaia Kyrilli
Aglaia Kyrilli
Department of Endocrinology, Hôpital Universitaire de Bruxelles (H.U.B.) - Hôpital Erasme, Université Libre de Bruxelles (ULB), Brussels, Belgium
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Bernard Corvilain
Bernard Corvilain
Department of Endocrinology, Hôpital Universitaire de Bruxelles (H.U.B.) - Hôpital Erasme, Université Libre de Bruxelles (ULB), Brussels, Belgium
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Sofie Bliddal
Sofie Bliddal
Department of Medical Endocrinology and Metabolism, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark
Department of Gynecology and Obstetrics, Copenhagen University Hospital (Hvidovre Hospital), Hvidovre, Denmark
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Department of Gynecology and Obstetrics, Copenhagen University Hospital (Hvidovre Hospital), Hvidovre, Denmark
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Dorthe Hansen Precht
Dorthe Hansen Precht
Department of Medical Endocrinology and Metabolism, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark
Carelink Nærhospital, Roskilde, Denmark
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Carelink Nærhospital, Roskilde, Denmark
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Ulla Feldt-Rasmussen
Ulla Feldt-Rasmussen
Department of Medical Endocrinology and Metabolism, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark
Institute of Clinical Medicine, Faculty of Health and Clinical Research, Copenhagen University, Copenhagen, Denmark
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Institute of Clinical Medicine, Faculty of Health and Clinical Research, Copenhagen University, Copenhagen, Denmark
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Kris Poppe
Kris Poppe
Department of Endocrinology, Centre Hospitalier Universitaire Saint-Pierre, Brussels, Belgium
Université Libre de Bruxelles (ULB), Brussels, Belgium
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Université Libre de Bruxelles (ULB), Brussels, Belgium
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deterioration in euthyroid women such as age, parity, BMI, TPOAb concentration, or initial TSH cutoff. Targeting the subgroup of women who could benefit the most from thyroid function monitoring during pregnancy could help to better identify ideal candidates for
Stine Linding Andersen
Stine Linding Andersen
Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
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Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
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Louise Knøsgaard
Louise Knøsgaard
Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
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Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
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Aase Handberg
Aase Handberg
Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
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Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
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Peter Vestergaard
Peter Vestergaard
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark
Steno Diabetes Center North Jutland, Aalborg University Hospital, Aalborg, Denmark
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Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark
Steno Diabetes Center North Jutland, Aalborg University Hospital, Aalborg, Denmark
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Stig Andersen
Stig Andersen
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
Department of Geriatrics, Aalborg University Hospital, Aalborg, Denmark
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Department of Geriatrics, Aalborg University Hospital, Aalborg, Denmark
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Introduction Maternal thyroid function in early pregnancy is a debated matter ( 1 , 2 ). The role of thyroid hormones in fetal brain development has long drawn ample attention to the potential adverse consequences of abnormal maternal thyroid
Boni Xiang
Boni Xiang
Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China
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Ran Tao
Ran Tao
Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China
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Xinhua Liu
Xinhua Liu
Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China
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Xiaoming Zhu
Xiaoming Zhu
Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China
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Min He
Min He
Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China
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Zengyi Ma
Zengyi Ma
Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China
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Yehong Yang
Yehong Yang
Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China
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Zhaoyun Zhang
Zhaoyun Zhang
Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China
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Yiming Li
Yiming Li
Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China
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Zhenwei Yao
Zhenwei Yao
Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China
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Yongfei Wang
Yongfei Wang
Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China
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Hongying Ye
Hongying Ye
Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China
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thyroid hormone changes was studied before and after remission of endogenous CS. In clinical practice, because of the lack of knowledge about this condition, some CS patients’ thyroid functions may be mistaken as evidence of hypothyroidism or
Caroline Serrano-Nascimento
Caroline Serrano-Nascimento
Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil
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Rafael Barrera Salgueiro
Rafael Barrera Salgueiro
Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil
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Kaio Fernando Vitzel
Kaio Fernando Vitzel
Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil
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Thiago Pantaleão
Thiago Pantaleão
Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
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Vânia Maria Corrêa da Costa
Vânia Maria Corrêa da Costa
Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
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Maria Tereza Nunes
Maria Tereza Nunes
Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil
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thyroid disorders ( 10 , 11 , 12 ). It is worth noting that the daily requirement of iodine consumption increases to 200–250 µg during pregnancy and lactation, in order to guarantee normal maternal thyroid function ( 13 ). Indeed, adequate maternal TH
Xiaoya Zheng
Xiaoya Zheng
Department of Endocrinology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Heng Xiao
Heng Xiao
Department of Hepatobiliary Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Jian Long
Jian Long
Department of Endocrinology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Qiang Wei
Qiang Wei
Prevention of Disease Department, Chongqing Jiulongpo District Hospital of Traditional Chinese Medicine, Chongqing, China
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Liping Liu
Liping Liu
Department of Ultrasound, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Liping Zan
Liping Zan
Department of Endocrinology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Wei Ren
Wei Ren
Department of Endocrinology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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-related adverse events (irAEs) ( 2 ). Among endocrine irAEs, thyroid dysfunction occurs most frequently in patients treated with anti-PD-1 therapy ( 3 , 4 ). The mechanism by which anti-PD-1 treatment causes abnormal thyroid function is not yet fully understood
Giorgio Radetti
Giorgio Radetti
Pediatrics, Regional Hospital, Bolzano, Italy
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Mariacarolina Salerno
Mariacarolina Salerno
Pediatrics, University Federico II, Naples, Italy
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Chiara Guzzetti
Chiara Guzzetti
Pediatric Endocrinology, Ospedale Pedatrico Microcitemico ‘A. Cao’ – AOB Cagliari, Cagliari, Italy
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Marco Cappa
Marco Cappa
Pediatric Endocrinology, Bambino Gesù Children Hospital, Roma, Italy
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Andrea Corrias
Andrea Corrias
Divisione di Endocrinologia Pediatrica, Ospedale Infantile Regina Margherita, Torino, Italy
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Alessandra Cassio
Alessandra Cassio
Department of Pediatrics, University of Bologna, Bologna, Italy
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Graziano Cesaretti
Graziano Cesaretti
Department of Pediatrics, University of Pisa, Pisa, Italy
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Roberto Gastaldi
Roberto Gastaldi
Paediatric Department, Gaslini Hospital, Genova, Italy
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Mario Rotondi
Mario Rotondi
Unit of Internal Medicine and Endocrinology, Fondazione Salvatore Maugeri I.R.C.C.S., ISPESL Laboratory for Endocrine Disruptors, University of Pavia, Pavia, Italy
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Fiorenzo Lupi
Fiorenzo Lupi
Pediatrics, Regional Hospital, Bolzano, Italy
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Antonio Fanolla
Antonio Fanolla
Department of Biostatistics, Regional Hospital, Bolzano, Italy
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Giovanna Weber
Giovanna Weber
Department of Pediatrics, Vita-Salute San Raffaele University, Milan, Italy
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Sandro Loche
Sandro Loche
Pediatric Endocrinology, Ospedale Pedatrico Microcitemico ‘A. Cao’ – AOB Cagliari, Cagliari, Italy
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Introduction Hashimoto’s thyroiditis (HT) is a frequent autoimmune disease that may present with a spectrum of altered thyroid function ranging from thyrotoxicosis to overt hypothyroidism. Treatment with l -thyroxine ( l -T4) is commonly
Till Ittermann
Till Ittermann
Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
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Rehman Mehmood Khattak
Rehman Mehmood Khattak
Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
Department of Zoology, Islamia College Peshawar (CU), Peshawar, Pakistan
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Department of Zoology, Islamia College Peshawar (CU), Peshawar, Pakistan
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Marcello R P Markus
Marcello R P Markus
Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany
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Jens-Peter Kühn
Jens-Peter Kühn
Institute of Radiology, University Hospital, Carl-Gustav-Carus University, Dresden, Germany
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Marie-Luise Kromrey
Marie-Luise Kromrey
Department of Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany
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Giovanni Targher
Giovanni Targher
Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Verona, Verona, Italy
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Antje Steveling
Antje Steveling
Department of Internal Medicine A, University Medicine Greifswald, Greifswald, Germany
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Matthias Nauck
Matthias Nauck
Institute for Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, University Medicine, Greifswald, Germany
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DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, University Medicine, Greifswald, Germany
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Henry Völzke
Henry Völzke
Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
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contents via proton-density fat fraction (PDFF) and transverse relaxation rate (R2*), respectively ( 8 , 9 , 10 ). As far as we know, there are no population-based studies that investigated the associations of thyroid function parameters with NAFLD and
W J Bom
W J Bom
Department of Internal Medicine, Rijnstate Hospital, Arnhem, the Netherlands
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F B M Joosten
F B M Joosten
Department of Radiology, Rijnstate Hospital, Arnhem, the Netherlands
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M M G J van Borren
M M G J van Borren
Department of Clinical Chemistry, Rijnstate Hospital, Arnhem, the Netherlands
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E P Bom
E P Bom
Department of Radiology, Rijnstate Hospital, Arnhem, the Netherlands
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R R J P van Eekeren
R R J P van Eekeren
Department of Surgery, Rijnstate Hospital, Arnhem, the Netherlands
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H de Boer
H de Boer
Department of Internal Medicine, Rijnstate Hospital, Arnhem, the Netherlands
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Introduction About 10% of the population has a benign non-functioning thyroid nodule (NFTN) of 1 cm or larger ( 1 ), and 4–7% of these nodules are symptomatic ( 2 , 3 , 4 ). Unilateral lobectomy and volume reduction by radioiodine (RAI) have
Yanling Cai
Yanling Cai
Department of Nuclear Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China
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Yan Yang
Yan Yang
Department of Nuclear Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China
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Xiao Pang
Xiao Pang
Department of Nuclear Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China
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Suping Li
Suping Li
Department of Nuclear Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China
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male gonadal function. To retrieve all the relevant studies, the following descriptors were used to build the search strategies: radioactive iodine therapy, 131 I, iodine 131, RAI, iodine, radioisotope, iodine radioisotope, thyroid cancer, thyroid
Hana Vítková
Hana Vítková
H Vítková, General University Hospital in Prague, Prague, 12000, Czech Republic
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Kateřina Anderlová
Kateřina Anderlová
K Anderlová, Department of Gynaecology, Obstetrics and Neonatology, First Faculty of Medicine, General University Hospital in Prague, Prague, Czech Republic
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Jan Krátký
Jan Krátký
J Krátký, Third Department of Medicine, General University Hospital in Prague, Prague, Czech Republic
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Radovan Bílek
Radovan Bílek
R Bílek, Institute of Endocrinology, Praha, Czech Republic
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Drahomíra Springer
Drahomíra Springer
D Springer, Institute of Clinical Biochemistry and Laboratory Medicine, General University Hospital in Prague, Prague, Czech Republic
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Felix Votava
Felix Votava
F Votava, Department of Children and Adolescents, University Hospital Kralovske Vinohrady, Praha, Czech Republic
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Tomáš Brutvan
Tomáš Brutvan
T Brutvan, 3rd Department of Medicine, General University Hospital in Prague, Prague, Czech Republic
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Adéla Krausová
Adéla Krausová
A Krausová, 3rd Department of Medicine, General University Hospital in Prague, Prague, Czech Republic
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Kristýna Žabková
Kristýna Žabková
K Žabková, 3rd Department of Medicine, General University Hospital in Prague, Prague, Czech Republic
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Eliška Potluková
Eliška Potluková
E Potluková, University Center of Internal Medicine, Cantonal Hospital Basel-Landschaft Department of Internal Medicine, Basel, Switzerland
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Jan Jiskra
Jan Jiskra
J Jiskra, 3rd Department of Medicine, General University Hospital in Prague, Prague, Czech Republic
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Introduction: Maternal urinary iodine concentration (UIC) and blood neonatal thyroid stimulating hormone (TSH) concentration reflect iodine status in pregnancy. As dietary measures in gestational diabetes mellitus (GDM) could affect iodine intake, our study aimed to investigate iodine supply in women with GDM compared to healthy pregnant women and to evaluate its relationship to thyroid function.
Methods: UIC and serum TSH, free thyroxine (FT4) and autoantibodies against thyroid peroxidase (TPOAb) were analysed in 195 women with GDM and 88 healthy pregnant women in the 2nd trimester. Subsequently, neonatal TSH concentrations measured 72 hours after delivery in a subgroup of 154 newborns (115 of mothers with GDM and 39 controls) from the national register were analysed.
Results: Optimal iodine intake was found only in nine women with GDM (4.6%) and 33 healthy pregnant women (37.5%) (P<0.001). Most pregnant women with GDM (88.7%) as compared to one half of controls (50%) had iodine deficiency (P<0.001). Also, hypothyroxinaemia was more prevalent in GDM compared to controls (12.3% vs 3.4%, P = 0.032). Consistently, neonatal TSH >5.0 mIU/L indicating iodine deficiency was found in 6 (5.2%) newborns of women with GDM as compared to none in controls. In the multiple logistic and linear regression models in women with GDM, hypothyroxinaemia was associated with preterm births, and a negative association of serum FT4 and HbA1c was found.
Conclusion: Iodine deficiency in pregnancy was more prevalent among women with GDM compared to healthy pregnant controls. Hypothyroxinaemia was associated with preterm births in women with GDM.
