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Ayako Sato Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

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Katsuya Matsuda Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

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Takahiro Motoyama Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

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Zhanna Mussazhanova Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Al-Farabi Kazakh National University, Almaty City, Republic of Kazakhstan

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Ryota Otsubo Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

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Hisayoshi Kondo Biostatics Section, Division of Scientific Data Registry, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

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Yuko Akazawa Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

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Miyoko Higuchi Department of Diagnostic Pathology and Cytology, Kuma Hospital, Kobe, Hyogo, Japan

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Ayana Suzuki Department of Diagnostic Pathology and Cytology, Kuma Hospital, Kobe, Hyogo, Japan

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Mitsuyoshi Hirokawa Department of Diagnostic Pathology and Cytology, Kuma Hospital, Kobe, Hyogo, Japan

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Akira Miyauchi Department of Diagnostic Pathology and Cytology, Kuma Hospital, Kobe, Hyogo, Japan

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Takeshi Nagayasu Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

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Masahiro Nakashima Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

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Introduction Thyroid follicular carcinoma (FC) must be differentiated from the more common follicular adenoma (FA). However, it is almost impossible to preoperatively diagnose follicular tumors (FTs) by fine-needle aspiration cytology (FNAC

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Flávia O Valentim Internal Medicine Department, Botucatu Medical School, Sao Paulo State University (Unesp), Botucatu, São Paulo, Brazil

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Bárbara P Coelho Internal Medicine Department, Botucatu Medical School, Sao Paulo State University (Unesp), Botucatu, São Paulo, Brazil

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Hélio A Miot Department of Dermatology, Botucatu Medical School, Sao Paulo State University (Unesp), Botucatu, São Paulo, Brazil

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Caroline Y Hayashi Internal Medicine Department, Botucatu Medical School, Sao Paulo State University (Unesp), Botucatu, São Paulo, Brazil

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Danilo T A Jaune Internal Medicine Department, Botucatu Medical School, Sao Paulo State University (Unesp), Botucatu, São Paulo, Brazil

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Cristiano C Oliveira Pathology Department, Botucatu Medical School, Sao Paulo State University (Unesp), Botucatu, São Paulo, Brazil

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Mariângela E A Marques Pathology Department, Botucatu Medical School, Sao Paulo State University (Unesp), Botucatu, São Paulo, Brazil

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José Vicente Tagliarini Otolaryngology and Head and Neck Surgery Department, Botucatu Medical School, Sao Paulo State University (Unesp), Botucatu, São Paulo, Brazil

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Emanuel C Castilho Otolaryngology and Head and Neck Surgery Department, Botucatu Medical School, Sao Paulo State University (Unesp), Botucatu, São Paulo, Brazil

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Paula Soares i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal
Cancer Signaling and Metabolism Group, Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Department of Pathology, Medical Faculty, University of Porto, Porto, Portugal

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Gláucia M F S Mazeto Internal Medicine Department, Botucatu Medical School, Sao Paulo State University (Unesp), Botucatu, São Paulo, Brazil

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Introduction The differential diagnosis of thyroid follicular lesions includes both benign tumors, such as follicular adenoma (FA) and malignant tumors, such as follicular carcinoma (FC) and follicular variant of papillary carcinoma (FVPC

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Simonetta Piana Pathology Unit, Azienda USL – IRCCS Reggio Emilia, Reggio Emilia, Italy

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Eleonora Zanetti Pathology Unit, Azienda USL – IRCCS Reggio Emilia, Reggio Emilia, Italy

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Alessandra Bisagni Pathology Unit, Azienda USL – IRCCS Reggio Emilia, Reggio Emilia, Italy

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Alessia Ciarrocchi Laboratory of Translational Research, Azienda USL – IRCCS Reggio Emilia, Reggio Emilia, Italy

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Davide Giordano Otolaryngology Unit, Azienda USL – IRCCS Reggio Emilia, Reggio Emilia, Italy

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Federica Torricelli Laboratory of Translational Research, Azienda USL – IRCCS Reggio Emilia, Reggio Emilia, Italy

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Teresa Rossi Laboratory of Translational Research, Azienda USL – IRCCS Reggio Emilia, Reggio Emilia, Italy

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Moira Ragazzi Pathology Unit, Azienda USL – IRCCS Reggio Emilia, Reggio Emilia, Italy

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to be addressed. In particular, the expression profile of this protein within the spectrum of thyroid tumors, benign and malignant, follicular-derived and medullary, has never been consistently investigated ( 23 ). Thus, in this work, we aimed at

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Ashley N Reeb Department of Otolaryngology, Head and Neck Surgery, Saint Louis University School of Medicine, Saint Louis, Missouri, USA

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Andrea Ziegler Department of Otolaryngology, Head and Neck Surgery, Saint Louis University School of Medicine, Saint Louis, Missouri, USA

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Reigh-Yi Lin Department of Otolaryngology, Head and Neck Surgery, Saint Louis University School of Medicine, Saint Louis, Missouri, USA

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Introduction Follicular thyroid cancer (FTC) is the second most frequently diagnosed thyroid cancer after papillary thyroid cancer (PTC). About 10,000 cases of FTC are diagnosed annually in the United States, comprising about 10–15% of all

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Adrian F Daly Department of Endocrinology, Centre Hospitalier Universitaire (CHU) de Liège, Liège Université, Domaine Universitaire du Sart-Tilman, Liège, Belgium

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Liliya Rostomyan Department of Endocrinology, Centre Hospitalier Universitaire (CHU) de Liège, Liège Université, Domaine Universitaire du Sart-Tilman, Liège, Belgium

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Daniela Betea Department of Endocrinology, Centre Hospitalier Universitaire (CHU) de Liège, Liège Université, Domaine Universitaire du Sart-Tilman, Liège, Belgium

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Jean-François Bonneville Department of Endocrinology, Centre Hospitalier Universitaire (CHU) de Liège, Liège Université, Domaine Universitaire du Sart-Tilman, Liège, Belgium

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Chiara Villa Department of Endocrinology, Centre Hospitalier Universitaire (CHU) de Liège, Liège Université, Domaine Universitaire du Sart-Tilman, Liège, Belgium
Department of Pathological Cytology and Anatomy, Foch Hospital, Paris, France

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Natalia S Pellegata Institute for Diabetes and Cancer, Helmholtz Zentrum München, Neuherberg, Germany

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Beatrice Waser Division of Cell Biology and Experimental Cancer Research, Institute of Pathology, University of Bern, Bern, Switzerland

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Jean-Claude Reubi Division of Cell Biology and Experimental Cancer Research, Institute of Pathology, University of Bern, Bern, Switzerland

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Catherine Waeber Stephan Clinique Générale Ste-Anne, Fribourg, Switzerland

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Emanuel Christ Department of Endocrinology, Diabetology and Metabolism, University Hospital Basel, University of Basel, Basel, Switzerland

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Albert Beckers Department of Endocrinology, Centre Hospitalier Universitaire (CHU) de Liège, Liège Université, Domaine Universitaire du Sart-Tilman, Liège, Belgium

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pituitary and thyroid tumors. Immunohistochemistry of the follicular thyroid cancer showed no AIP staining ( Fig. 4 ). Similarly, the pituitary adenoma in Patient 2 had low or absent AIP staining on immunohistochemistry ( Fig. 4 ). Further immunostaining

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Ana P Estrada-Flórez Genome Center and Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, California, USA
Grupo de Citogenética, Filogenia y Evolución de Poblaciones, Facultad de Ciencias y Facultad de Ciencias de la Salud, Universidad del Tolima, Ibagué, Tolima, Colombia
Facultad de Ciencias para la Salud, Universidad de Caldas, Manizales, Caldas, Colombia

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Mabel E Bohórquez Grupo de Citogenética, Filogenia y Evolución de Poblaciones, Facultad de Ciencias y Facultad de Ciencias de la Salud, Universidad del Tolima, Ibagué, Tolima, Colombia

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Alejandro Vélez Dinamica IPS, Medellín, Antioquia, Colombia
Hospital Pablo Tobón Uribe, Medellín, Antioquia, Colombia

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Carlos S Duque Hospital Pablo Tobón Uribe, Medellín, Antioquia, Colombia

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Jorge H Donado Hospital Pablo Tobón Uribe, Medellín, Antioquia, Colombia

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Gilbert Mateus Hospital Federico Lleras Acosta, Ibagué, Tolima, Colombia

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Cesar Panqueba-Tarazona Universidad Surcolombiana, Neiva, Huila, Colombia

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Guadalupe Polanco-Echeverry Genome Center and Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, California, USA

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Ruta Sahasrabudhe Genome Center and Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, California, USA

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Magdalena Echeverry Grupo de Citogenética, Filogenia y Evolución de Poblaciones, Facultad de Ciencias y Facultad de Ciencias de la Salud, Universidad del Tolima, Ibagué, Tolima, Colombia

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Luis G Carvajal-Carmona Genome Center and Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, California, USA
Dinamica IPS, Medellín, Antioquia, Colombia
University of California Davis Comprehensive Cancer Center, Sacramento, California, USA
Fundación de Genética y Genómica, Medellín, Antioquia, Colombia

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, 5 , 6 ). We have previously shown that Colombian PTC patients have a higher prevalence of indicators of severity and aggressive tumor behavior, such as large size, extra-thyroid extension, and lymph node and distant metastasis, than reported in

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Keiko Ohkuwa Department of Surgery, Ito Hospital, Tokyo, Japan

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Kiminori Sugino Department of Surgery, Ito Hospital, Tokyo, Japan

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Mitsuji Nagahama Department of Surgery, Ito Hospital, Tokyo, Japan

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Wataru Kitagawa Department of Surgery, Ito Hospital, Tokyo, Japan

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Kenichi Matsuzu Department of Surgery, Ito Hospital, Tokyo, Japan

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Akifumi Suzuki Department of Surgery, Ito Hospital, Tokyo, Japan

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Chisato Tomoda Department of Surgery, Ito Hospital, Tokyo, Japan

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Kiyomi Hames Department of Surgery, Ito Hospital, Tokyo, Japan

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Junko Akaishi Department of Surgery, Ito Hospital, Tokyo, Japan

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Chie Masaki Department of Surgery, Ito Hospital, Tokyo, Japan

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Koichi Ito Department of Surgery, Ito Hospital, Tokyo, Japan

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patients with DTC and is predominantly observed in the lungs and bone ( 3 , 4 , 5 , 6 ). When treating metastatic tumors of differentiated thyroid carcinoma, a favorable prognosis can be expected after radioactive iodine (RAI) therapy after total

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David T Broome Department of Endocrinology, Diabetes & Metabolism, Cleveland Clinic Foundation, Cleveland, Ohio, USA

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Gauri B Gadre Department of Internal Medicine, Scripps Clinic, La Jolla, California, USA

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Ehsan Fayazzadeh Department of Radiology, Cleveland Clinic Foundation, Cleveland, Ohio, USA

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James F Bena Department of Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, Ohio, USA

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Christian Nasr Department of Endocrinology, Diabetes & Metabolism, Cleveland Clinic Foundation, Cleveland, Ohio, USA

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(OS) and cancer-specific survival (CSS). Significant risk factors that were identified for a decrease in survival included follicular thyroid cancer, age >45 years ( 8 ), cancer with metastasis to bone ( 5 ), increased tumor size ( 8 ) and tumor size

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Ana Carolina de Jesus Paniza Division of Genetics, Department of Morphology and Genetics, Genetic Bases of Thyroid Tumors Laboratory, Universidade Federal de São Paulo, São Paulo, Brazil

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Thais Biude Mendes Division of Genetics, Department of Morphology and Genetics, Genetic Bases of Thyroid Tumors Laboratory, Universidade Federal de São Paulo, São Paulo, Brazil

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Matheus Duarte Borges Viana Division of Genetics, Department of Morphology and Genetics, Genetic Bases of Thyroid Tumors Laboratory, Universidade Federal de São Paulo, São Paulo, Brazil

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Débora Mota Dias Thomaz Division of Genetics, Department of Morphology and Genetics, Genetic Bases of Thyroid Tumors Laboratory, Universidade Federal de São Paulo, São Paulo, Brazil

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Paula B O Chiappini Department of Pathology, Hospital Heliópolis, São Paulo, Brazil

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Gabriel A Colozza-Gama Division of Genetics, Department of Morphology and Genetics, Genetic Bases of Thyroid Tumors Laboratory, Universidade Federal de São Paulo, São Paulo, Brazil

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Susan Chow Lindsey Division of Endocrinology, Department of Medicine, Laboratory of Molecular and Translational Endocrinology, Universidade Federal de São Paulo, São Paulo, Brazil

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Marcos Brasilino de Carvalho Department of Head and Neck Surgery and Otorhinolaryngology, Hospital Heliópolis, São Paulo, Brazil

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Venâncio Avancini Ferreira Alves Department of Pathology, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil

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Otavio Curioni Department of Head and Neck Surgery and Otorhinolaryngology, Hospital Heliópolis, São Paulo, Brazil

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André Uchimura Bastos Division of Genetics, Department of Morphology and Genetics, Genetic Bases of Thyroid Tumors Laboratory, Universidade Federal de São Paulo, São Paulo, Brazil
Department of Microbiology, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil

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Janete Maria Cerutti Division of Genetics, Department of Morphology and Genetics, Genetic Bases of Thyroid Tumors Laboratory, Universidade Federal de São Paulo, São Paulo, Brazil

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follicular thyroid neoplasm with papillary-like nuclear features (NIFTPs). This distinct entity, which is considered a ‘premalignant’ lesion, was included in the 2017 World Health Organization Classification of Tumors of Endocrine Organs book ( 13 ). However

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Klaudia Zajkowska Endocrinology, Holycross Cancer Centre, Kielce, Poland

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Janusz Kopczyński Surgical Pathology, Holycross Cancer Centre, Kielce, Poland

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Stanisław Góźdź Faculty of Health Sciences, Jan Kochanowski University, Kielce, Poland

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Aldona Kowalska Endocrinology, Holycross Cancer Centre, Kielce, Poland
Faculty of Health Sciences, Jan Kochanowski University, Kielce, Poland

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al . Nomenclature revision for encapsulated follicular variant of papillary thyroid carcinoma: a paradigm shift to reduce overtreatment of indolent tumors . JAMA Oncology 2016 2 1023 – 1029 . ( https://doi.org/10.1001/jamaoncol.2016.0386 ) 5

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