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Aaron Lerner, Patricia Jeremias, and Torsten Matthias

Introduction Hashimoto's thyroiditis Hashimoto’s thyroiditis (HT) is one of the most common autoimmune endocrine diseases, characterized by an autoimmune-mediated destruction of the thyroid gland. Initially considered a rarity, HT has now

Open access

Madalena von Hafe, João Sergio Neves, Catarina Vale, Marta Borges-Canha, and Adelino Leite-Moreira

Introduction Thyroid hormones (THs) play fundamental roles in cardiovascular homeostasis ( 1 ). Given that cardiovascular diseases are among the most prevalent illnesses worldwide, causing substantial mortality, morbidity and hospitalization

Open access

Dorte Glintborg, Katrine Hass Rubin, Mads Nybo, Bo Abrahamsen, and Marianne Andersen

antibodies ( 8 ). A recent meta-analysis reported an odds ratio (OR) of 3.3 (95% CI 2.3–4.6) for autoimmune thyroid disease in women with PCOS ( 9 ). The risk of overt hypothyroidism in PCOS is less described than the risk of autoimmune thyroiditis. In a

Open access

L E Zijlstra, D M van Velzen, S Simsek, S P Mooijaart, M van Buren, D J Stott, I Ford, J W Jukema, and S Trompet

thyroid disease and variations in the definitions of subclinical thyroid disease among different studies. In an attempt to tackle these limitations, recent large, individual participant data meta-analyses were performed and associations were found between

Open access

Weiwei He, Bin Wang, Kaida Mu, Jing Zhang, Yanping Yang, Wei Yao, Sheli Li, and Jin-an Zhang

Introduction In autoimmune thyroid diseases (AITDs), one of the autoimmune diseases, cytokine-mediated immunity play a key role during the pathogenesis and development ( 1 ). AITDs are common endocrine autoimmune diseases with prevalence of

Open access

Mírian Romitti, Vitor C Fabris, Patricia K Ziegelmann, Ana Luiza Maia, and Poli Mara Spritzer

association between PCOS and autoimmune diseases ( 21 , 22 ) and especially autoimmune thyroid diseases (AITD), the most common form of autoimmune disorder, with an estimated prevalence of 5% ( 23 , 24 , 25 ). AITD results from a dysregulation of the

Open access

Irfan Vardarli, Manuel Weber, Frank Weidemann, Dagmar Führer, Ken Herrmann, and Rainer Görges

and corresponds to 1–3% of all histologically proven thyroid cancers in the United States, with a prevalence of 0.1–1.4% in patients with nodular thyroid disease ( 2 , 4 ), appearing either sporadically or in a hereditary form as a component of the

Open access

Yun Cai, Jieni Yan, Yong Gu, Heng Chen, Yang Chen, Xinyu Xu, Mei Zhang, Liping Yu, Xuqin Zheng, and Tao Yang

Objective: The most common coexisting organ-specific autoimmune disease in patients with type 1 diabetes mellitus (T1DM) is autoimmune thyroid disease (AITD). However, there have been little clinical reports based on large population about the prevalence of zinc transporter 8 autoantibody (ZnT8A) and other islet autoantibodies in AITD patients. We aimed to explore the presence of islet autoantibodies, ZnT8A, glutamic acid decarboxylase autoantibodies (GADA) and insulinoma-associated antigen 2 autoantibodies (IA-2A) compared with thyroid autoantibodies, thyroid peroxidase autoantibodies (TPOAb) and thyroglobulin autoantibodies (TGAb) and thyrotropin receptor autoantibodies (TRAb) in patients with Graves’ disease (GD), Hashimoto’s thyroiditis (HT) and T1DM patients with AITD.

Methods: Totally, 389 patients with GD, 334 patients with HT, 108 T1DM patients with AITD and 115 healthy controls (HC) were recruited in the study. Islet autoantibodies (ZnT8A, GADA and IA-2A) were detected by radioligand binding assay. Thyroid autoantibodies, TPOAb and TGAb were detected by chemiluminescence assay, and TRAb was detected by radioimmunoassay.

Results: The prevalence of ZnT8A, GADA and IA-2A was higher in GD and HT patients than that of HC (ZnT8A: GD 8.48%, HT 10.8% vs HC 1.74%; GADA: GD 7.46%, HT 7.74% vs HC 0.870%; IA-2A: GD 4.88%, HT 3.59% vs HC 0%; All P<0.05); but lower than that of T1DM subjects with AITD (ZnT8A: 42.6%; IA-2A: 44.4%; GADA: 74.1%; all P<0.0001).

Conclusions: An increased prevalence of ZnT8A as well as GADA and IA-2A was found in both GD and HT patients, indicating that there is a potential link between thyroid autoimmunity and islet autoimmunity.

Open access

A Rouland, J-C Chauvet-Gelinier, A-L Sberna, E Crevisy, P Buffier, T Mouillot, J-M Petit, and B Vergès

results impossible. Patients with auto-immune thyroid diseases Eighty-five patients with auto-immune thyroid disease (Graves’ disease or Hashimoto’s thyroiditis) were included. These patients were out-patients followed by the physicians in the

Open access

Jia Liu, Min Liu, Zhe Chen, Yumei Jia, and Guang Wang

Introduction Autoimmune thyroiditis (AIT) is the most common autoimmune thyroid disease ( 1 , 2 ). Because of varying degree of thyroid destruction, AIT patients manifest with different thyroid function including euthyroidism, subclinical or