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Catarina Tavares, Maria João Coelho, Catarina Eloy, Miguel Melo, Adriana Gaspar da Rocha, Ana Pestana, Rui Batista, Luciana Bueno Ferreira, Elisabete Rios, Samia Selmi-Ruby, Bruno Cavadas, Luísa Pereira, Manuel Sobrinho Simões, and Paula Soares

function. However, no clear answer emerged from the results obtained in the previous studies. Despite the central role of NIS in diagnosis, treatment and follow-up of thyroid cancer patients, reliable methods for ascertaining NIS expression and

Open access

Susana Pastor, Abdelmounaim Akdi, Eddy R González, Juan Castell, Josefina Biarnés, Ricard Marcos, and Antonia Velázquez

Introduction Thyroid cancer is of special concern in endocrinology practice, accounting for more than 90% of all endocrine cancers. Moreover, its incidence is increasing in developed countries (1, 2) . Differentiated thyroid carcinoma (DTC

Open access

Chiara Mele, Maria Teresa Samà, Alessandro Angelo Bisoffi, Marina Caputo, Valentina Bullara, Stefania Mai, Gillian Elisabeth Walker, Flavia Prodam, Paolo Marzullo, Gianluca Aimaretti, and Loredana Pagano

Introduction The incidence rates of differentiated thyroid cancer (DTC) have been rising in many countries over the last few decades ( 1 , 2 ) along with a parallel increase in obesity and metabolic disorders ( 3 ). Even if the growing

Open access

M L Gild, M Bullock, C K Pon, B G Robinson, and R J Clifton-Bligh

including prostate (9) , non small cell lung cancer (10) , and osteosarcoma (11) . With regard to thyroid cancer, early studies have yielded data that supports the potential clinical utility of targeting HSP90 to treat this disease. 17-AAG has showed an

Open access

Tiemo S Gerber, Arno Schad, Nils Hartmann, Erik Springer, Ulrich Zechner, and Thomas J Musholt

Introduction Poorly differentiated thyroid carcinoma (PDTC) represents an aggressive variant of thyroid cancer that predominantly arises from the differentiated variants of papillary and follicular thyroid carcinoma (PTC and FTC, respectively

Open access

Joanna Klubo-Gwiezdzinska, John Costello Jr, Kirk Jensen, Aneeta Patel, Rok Tkavc, Douglas Van Nostrand, Kenneth D Burman, Leonard Wartofsky, and Vasyl Vasko

Introduction Standard treatment of thyroid cancer consists of surgical resection and radioiodine ( 131 I) therapy ( 1 ). Depending on the risk stratification of the individual patient, the primary goal of the application of radioactive iodine

Open access

Zeming Liu, Di Hu, Yihui Huang, Sichao Chen, Wen Zeng, Ling Zhou, Wei Zhou, Min Wang, Haifeng Feng, Wei Wei, Chao Zhang, Danyang Chen, and Liang Guo

carcinoma. Among pediatric patients, papillary thyroid carcinoma and follicular thyroid cancer account for more than 90% ( 2 ) of all childhood cases. However, medulary thyroid cancer, poorly differentiated tumors and undifferentiated (anaplastic) thyroid

Open access

T Grimmichova, M Haluzik, K Vondra, P Matucha, and M Hill

Introduction Thyroid cancer (TC) is a relatively rare cancer, with an incidence from 1 to 5.3% of all malignancies, but it represents the most common malignancy originating from the endocrine organs. The most common TCs are differentiated

Open access

Simonetta Piana, Eleonora Zanetti, Alessandra Bisagni, Alessia Ciarrocchi, Davide Giordano, Federica Torricelli, Teresa Rossi, and Moira Ragazzi

the prototype and by far the most studied member of this family of receptors. NOTCH1 as other members of this family has been involved in the development of thyroid cancer even if with controversial role. On one side the activation of NOTCH signaling

Open access

Jes Sloth Mathiesen, Jens Peter Kroustrup, Peter Vestergaard, Per Løgstrup Poulsen, Åse Krogh Rasmussen, Ulla Feldt-Rasmussen, Sten Schytte, Stefano Christian Londero, Henrik Baymler Pedersen, Christoffer Holst Hahn, Jens Bentzen, Sören Möller, Mette Gaustadnes, Maria Rossing, Finn Cilius Nielsen, Kim Brixen, Christian Godballe, and Danish Thyroid Cancer Group (DATHYRCA)

between January 1960 and December 2014, was constructed through three nationwide registries: the Danish Thyroid Cancer Database, the Danish Cancer Registry and the Danish Pathology Register ( 13 , 14 , 15 ). This has been described in detail previously