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Alexander Heinzel RWTH University Hospital Aachen, Department of Nuclear Medicine, Aachen, Germany

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Dirk Müller Institute for Health Economics and Clinical Epidemiology, University of Cologne, Cologne, Germany

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Hanneke M van Santen Wilhelmina Children’s Hospital, University Medical Center Utrecht, Department of Pediatric Endocrinology, Utrecht, The Netherlands
Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands

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Sarah C Clement Wilhelmina Children’s Hospital, University Medical Center Utrecht, Department of Pediatric Endocrinology, Utrecht, The Netherlands
Emma Children’s Hospital, Amsterdam UMC, Department of Pediatrics, Amsterdam, The Netherlands

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Arthur B Schneider University of Illinois at Chicago, Department of Medicine, Chicago, IL, USA

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Frederik A Verburg Erasmus MC Rotterdam, Department of Radiology & Nuclear Medicine, Rotterdam, The Netherlands
University Hospital Würzburg, Department of Nuclear Medicine, Würzburg, Germany

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-related mortality. Therefore, the aim of the present study was to perform a comparative analysis of the different clinically used surveillance strategies mentioned above for their effect on DTC-related survival. Materials and methods Literature search

Article Type:
Review Article
Collections:
Thyroid
DOI:
https://doi.org/10.1530/EC-22-0092
Volume/Issue:
Volume 11: Issue 12
Open access
Jes Sloth Mathiesen Department of ORL Head & Neck Surgery and Audiology, Odense University Hospital, Odense, Denmark
Department of Clinical Research, University of Southern Denmark, Odense, Denmark

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Jens Peter Kroustrup Department of Clinical Medicine and Endocrinology, Aalborg University Hospital, Aalborg, Denmark

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Peter Vestergaard Department of Clinical Medicine and Endocrinology, Aalborg University Hospital, Aalborg, Denmark
Steno Diabetes Center North Jutland, Aalborg, Denmark

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Per Løgstrup Poulsen Department of Internal Medicine and Endocrinology, Aarhus University Hospital, Aarhus, Denmark

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Åse Krogh Rasmussen Department of Medical Endocrinology, Copenhagen University Hospital, Copenhagen, Denmark

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Ulla Feldt-Rasmussen Department of Medical Endocrinology, Copenhagen University Hospital, Copenhagen, Denmark

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Sten Schytte Department of ORL Head & Neck Surgery, Aarhus University Hospital, Aarhus, Denmark

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Stefano Christian Londero Department of ORL Head & Neck Surgery, Aarhus University Hospital, Aarhus, Denmark

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Henrik Baymler Pedersen Department of ORL Head & Neck Surgery, Aalborg University Hospital, Aalborg, Denmark

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Christoffer Holst Hahn Department of ORL Head & Neck Surgery, Copenhagen University Hospital, Copenhagen, Denmark

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Jens Bentzen Department of Oncology, Herlev Hospital, Herlev, Denmark

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Sören Möller Department of Clinical Research, University of Southern Denmark, Odense, Denmark
Odense Patient data Explorative Network (OPEN), Odense University Hospital, Odense, Denmark

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Mette Gaustadnes Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark

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Maria Rossing Center for Genomic Medicine, Copenhagen University Hospital, Copenhagen, Denmark

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Finn Cilius Nielsen Center for Genomic Medicine, Copenhagen University Hospital, Copenhagen, Denmark

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Kim Brixen Department of Clinical Research, University of Southern Denmark, Odense, Denmark

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Christian Godballe Department of ORL Head & Neck Surgery and Audiology, Odense University Hospital, Odense, Denmark

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Danish Thyroid Cancer Group (DATHYRCA)
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until death, emigration or last follow-up (January 1, 2018), whichever came first. For calculation of overall and disease-specific survival, all deaths and deaths due to MTC were considered as an event, respectively. Statistical analysis

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0494
Volume/Issue:
Volume 8: Issue 1
Open access
Zherui Fu Department of Emergency, The First People’s Hospital of Xiaoshan District, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, Zhejiang, China

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Yi Lai Department of Emergency, The First People’s Hospital of Xiaoshan District, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, Zhejiang, China

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Qianfei Wang Department of Emergency, The First People’s Hospital of Xiaoshan District, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, Zhejiang, China

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Feng Lin Department of Orthopedics, The First People's Hospital of Xiaoshan District, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, Zhejiang, China

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Jiaping Fang Department of Emergency, The First People’s Hospital of Xiaoshan District, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, Zhejiang, China

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’. Kaplan–Meier curve analysis Data processing and visualization were performed using R software (R version 4.2.1). We used the R package ‘survival’ to conduct KM cure analysis on the previously processed data. The results were visualized by the R package

Article Type:
Research Article
Collections:
Thyroid
DOI:
https://doi.org/10.1530/EC-23-0418
Volume/Issue:
Volume 13: Issue 1
Open access
Hanbaro Kim Department of Surgery, Hallym University College of Medicine, Chuncheon, Republic of Korea

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Ki Byung Song Division of Hepatobilliary and Pancreatic Surgery, Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea

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Dae Wook Hwang Division of Hepatobilliary and Pancreatic Surgery, Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea

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Jae Hoon Lee Division of Hepatobilliary and Pancreatic Surgery, Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea

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Shadi Alshammary Department of Surgery, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia

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Song Cheol Kim Division of Hepatobilliary and Pancreatic Surgery, Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea

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mean tumor size of NF-PNETs over time. When we analyzed the tumor grade over time, the proportion of grade G3 tumors was lowest (6.6%) in the late period. In the survival analysis, we found that DSS and DFS according to each time period tended to

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0282
Volume/Issue:
Volume 8: Issue 7
Open access
Enrique Pedernera Universidad Nacional Autónoma de México, Facultad de Medicina, Departamento de Embriología y Genética, Ciudad de México, México

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Flavia Morales-Vásquez Instituto Nacional de Cancerología, Ciudad de México, México

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María J Gómora Universidad Nacional Autónoma de México, Facultad de Medicina, Departamento de Embriología y Genética, Ciudad de México, México

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Miguel A Almaraz Universidad Nacional Autónoma de México, Facultad de Medicina, Departamento de Embriología y Genética, Ciudad de México, México

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Esteban Mena Universidad Nacional Autónoma de México, Facultad de Medicina, Secretaría General, Ciudad de México, México
Universidad La Salle, Posgrado de la Facultad de Ciencias Químicas, Ciudad de México, México

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Delia Pérez-Montiel Instituto Nacional de Cancerología, Ciudad de México, México

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Elizabeth Rendon Hospital Militar de Especialidades de la Mujer y Neonatología. Ciudad de México, México

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Horacio López-Basave Instituto Nacional de Cancerología, Ciudad de México, México

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Juan Maldonado-Cubas Universidad La Salle, Posgrado de la Facultad de Ciencias Químicas, Ciudad de México, México

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Carmen Méndez Universidad Nacional Autónoma de México, Facultad de Medicina, Departamento de Embriología y Genética, Ciudad de México, México

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proportions ( Z -value). Analysis of the association between HSD17β1 expression, tumor subtypes and FIGO clinical stage was performed by chi-squared test. Significance in Kaplan–Meier survival curves was obtained using log-rank values. Hazard ratio and

Article Type:
Research Article
Collections:
Hormones and Cancer
DOI:
https://doi.org/10.1530/EC-23-0315
Volume/Issue:
Volume 12: Issue 12
Open access
Ashley K Clift Department of Surgery and Cancer, Imperial College London, London, UK

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Omar Faiz Department of Surgery, St Mark’s Hospital, London, UK

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Robert Goldin Centre for Pathology, Imperial College London, London, UK

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John Martin Department of Gastroenterology, Imperial College London, London, UK

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Harpreet Wasan Department of Surgery and Cancer, Imperial College London, London, UK

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Marc-Olaf Liedke Department of Surgery, Westkuesten Klinikum Heide, Heide, Germany

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Erik Schloericke Department of Surgery, Westkuesten Klinikum Heide, Heide, Germany

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Anna Malczewska Department of Surgery and Cancer, Imperial College London, London, UK
Department of Pathophysiology and Endocrinology, Medical University of Silesia, Katowice, Poland

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Guido Rindi Institute of Anatomic Pathology, Universita Cattolica del Sacro Cuore, Rome, Italy

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Mark Kidd Wren Laboratories, Branford, Connecticut, USA

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Irvin M Modlin Emeritus Professor Gastrointestinal Surgery, School of Medicine, Yale University, New Haven, Connecticut, USA

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Andrea Frilling Department of Surgery and Cancer, Imperial College London, London, UK

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IIIA, 19 (27.1%) were stage IIIB and 44 (62.9%) were stage IV at the time of initial presentation. On Kaplan–Meier analysis, the median estimated survival for patients with G1 tumours was 156 months. For G2 tumours, no median estimated survival could

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-16-0114
Volume/Issue:
Volume 6: Issue 2
Open access
Wentao Zhou The Research Institution of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China
Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Tiantao Kuang The Research Institution of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Xu Han Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Wenqi Chen Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Xuefeng Xu The Research Institution of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Wenhui Lou Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Dansong Wang The Research Institution of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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cut-off values of LMR for G1, G2 and G3 were 5.0, 4.4 and 3.5, respectively (Supplementary Fig. 4). Survival analysis manifested that LMR >4.4 was associated with favorable prognosis in G2 patients ( P  = 0.020), but no statistical difference was

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0541
Volume/Issue:
Volume 9: Issue 4
Open access
Matteo Scopel Medical Clinic III, Department of Medicine (DIMED), University Hospital of Padua, Padua, Italy

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Eugenio De Carlo Medical Clinic III, Department of Medicine (DIMED), University Hospital of Padua, Padua, Italy

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Francesca Bergamo Unit of Medical Oncology 1, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy

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Sabina Murgioni Unit of Medical Oncology 1, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy

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Riccardo Carandina Radiodiagnostic Unit, University Hospital of Padua, Padua, Italy

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Anna Rita Cervino Radiotherapy and Nuclear Medicine Unit, Istituto Oncologico Veneto IOV-IRCCS, Padua, Italy

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Marta Burei Radiotherapy and Nuclear Medicine Unit, Istituto Oncologico Veneto IOV-IRCCS, Padua, Italy

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Federica Vianello Radiotherapy and Nuclear Medicine Unit, Istituto Oncologico Veneto IOV-IRCCS, Padua, Italy

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Vittorina Zagonel Unit of Medical Oncology 1, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy

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Matteo Fassan Surgical Pathology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy

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Roberto Vettor Medical Clinic III, Department of Medicine (DIMED), University Hospital of Padua, Padua, Italy

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diagnosis (evaluated by the same morpho-functional analysis), that appeared after 6 months or later. By defining these two groups we analyzed the possible differences in terms of tumor aggressiveness and patient survival. Moreover, we tried to investigate

Article Type:
Research Article
Collections:
Hormones and Cancer
DOI:
https://doi.org/10.1530/EC-21-0568
Volume/Issue:
Volume 11: Issue 7
Open access
Lauren E Henke Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri, USA

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John D Pfeifer Department of Pathology, Washington University School of Medicine, St. Louis, Missouri, USA

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Thomas J Baranski Division of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, Washington University School of Medicine, Saint Louis, Missouri, USA

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Todd DeWees Division of Biomedical Statistics and Informatics, Mayo Clinic, Scottsdale, Arizona, USA

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Perry W Grigsby Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri, USA
Division of Nuclear Medicine, Mallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, Missouri, USA

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analysis of 542 patients with established BRAF status, presence of the BRAF mutation did not independently predict C-PTC histology. Patient outcomes For the entire cohort, overall survival was 92.5 and 90.3% at 10 and 15 years, respectively. RFS

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0264
Volume/Issue:
Volume 7: Issue 12
Open access
Keiko Ohkuwa Department of Surgery, Ito Hospital, Tokyo, Japan

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Kiminori Sugino Department of Surgery, Ito Hospital, Tokyo, Japan

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Mitsuji Nagahama Department of Surgery, Ito Hospital, Tokyo, Japan

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Wataru Kitagawa Department of Surgery, Ito Hospital, Tokyo, Japan

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Kenichi Matsuzu Department of Surgery, Ito Hospital, Tokyo, Japan

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Akifumi Suzuki Department of Surgery, Ito Hospital, Tokyo, Japan

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Chisato Tomoda Department of Surgery, Ito Hospital, Tokyo, Japan

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Kiyomi Hames Department of Surgery, Ito Hospital, Tokyo, Japan

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Junko Akaishi Department of Surgery, Ito Hospital, Tokyo, Japan

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Chie Masaki Department of Surgery, Ito Hospital, Tokyo, Japan

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Koichi Ito Department of Surgery, Ito Hospital, Tokyo, Japan

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detected, and a log-rank test was used to determine the significance. The Cox proportional hazards model was performed to determine the hazard ratio (HRs) of variables with 95% CIs for survival rate. Multivariate analysis using the Cox proportional hazards

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-21-0215
Volume/Issue:
Volume 10: Issue 8
Open access