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Peter D Mark Department of Medicine O, Department of Clinical Physiology and Nuclear Medicine, Department of Clinical Physiology, Faculty of Health Sciences, Center for Functional and Diagnostic Imaging and Research, Centre of Endocrinology and Metabolism, Herlev University Hospital, Herlev Ringvej 75, Herlev DK‐2730, Denmark

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Mikkel Andreassen Department of Medicine O, Department of Clinical Physiology and Nuclear Medicine, Department of Clinical Physiology, Faculty of Health Sciences, Center for Functional and Diagnostic Imaging and Research, Centre of Endocrinology and Metabolism, Herlev University Hospital, Herlev Ringvej 75, Herlev DK‐2730, Denmark

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Claus L Petersen Department of Medicine O, Department of Clinical Physiology and Nuclear Medicine, Department of Clinical Physiology, Faculty of Health Sciences, Center for Functional and Diagnostic Imaging and Research, Centre of Endocrinology and Metabolism, Herlev University Hospital, Herlev Ringvej 75, Herlev DK‐2730, Denmark
Department of Medicine O, Department of Clinical Physiology and Nuclear Medicine, Department of Clinical Physiology, Faculty of Health Sciences, Center for Functional and Diagnostic Imaging and Research, Centre of Endocrinology and Metabolism, Herlev University Hospital, Herlev Ringvej 75, Herlev DK‐2730, Denmark

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Andreas Kjaer Department of Medicine O, Department of Clinical Physiology and Nuclear Medicine, Department of Clinical Physiology, Faculty of Health Sciences, Center for Functional and Diagnostic Imaging and Research, Centre of Endocrinology and Metabolism, Herlev University Hospital, Herlev Ringvej 75, Herlev DK‐2730, Denmark
Department of Medicine O, Department of Clinical Physiology and Nuclear Medicine, Department of Clinical Physiology, Faculty of Health Sciences, Center for Functional and Diagnostic Imaging and Research, Centre of Endocrinology and Metabolism, Herlev University Hospital, Herlev Ringvej 75, Herlev DK‐2730, Denmark

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Jens Faber Department of Medicine O, Department of Clinical Physiology and Nuclear Medicine, Department of Clinical Physiology, Faculty of Health Sciences, Center for Functional and Diagnostic Imaging and Research, Centre of Endocrinology and Metabolism, Herlev University Hospital, Herlev Ringvej 75, Herlev DK‐2730, Denmark
Department of Medicine O, Department of Clinical Physiology and Nuclear Medicine, Department of Clinical Physiology, Faculty of Health Sciences, Center for Functional and Diagnostic Imaging and Research, Centre of Endocrinology and Metabolism, Herlev University Hospital, Herlev Ringvej 75, Herlev DK‐2730, Denmark

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Background Subclinical hyperthyroidism (SH) is defined by the biochemical pattern of reduced or undetectable serum thyroid-stimulating hormone (TSH) levels and thyroid hormone levels within the reference range. SH is seen with increasing frequency

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-14-0137
Volume/Issue:
Volume 4: Issue 1
Open access
Thera P Links Division of Endocrinology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

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Trynke van der Boom Division of Endocrinology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

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Wouter T Zandee Division of Endocrinology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

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Joop D Lefrandt Division of Vascular Medicine, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

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the impact of overt and subclinical hyperthyroidism on the cardiovascular system. We will thereafter present the latest insights on the cardiac effects of thyroid suppression therapy for the treatment of thyroid cancer. Finally, we will show new

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-20-0539
Volume/Issue:
Volume 10: Issue 1
Open access
L E Zijlstra Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands

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D M van Velzen Department of Internal Medicine, Section of Endocrinology, Northwest Clinics, Alkmaar, The Netherlands

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S Simsek Department of Internal Medicine, Section of Endocrinology, Northwest Clinics, Alkmaar, The Netherlands

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S P Mooijaart Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands

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M van Buren Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
Department of Internal Medicine, HagaHospital, The Hague, The Netherlands

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D J Stott Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK

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I Ford Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK

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J W Jukema Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands

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S Trompet Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands

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Introduction Subclinical hyperthyroidism has been linked to atrial fibrillation and coronary artery calcification, whereas subclinical hypothyroidism has been associated with hypercholesterolemia and atherosclerosis ( 1 , 2 ). Despite these

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0502
Volume/Issue:
Volume 9: Issue 1
Open access
Xingyao Tang Beijing Tongren Hospital, Capital Medical University

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Zhi-Hui Song Department of Pharmacy, Beijing Tongren Hospital, Capital Medical University, Beijing, China

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Dawei Wang General Practice Department, Beijing Tongren Hospital, Capital Medical University, Beijing, China

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Jinkui Yang Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China

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Marly Augusto Cardoso Department of Nutrition, School of Public Health, University of Sao Paulo, Sao Paulo, Brazil

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Jian-Bo Zhou Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China

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Rafael Simó Endocrinology and Nutrition Department, Hospital Universitari Vall d’Hebron, Diabetes and Metabolism Research Unit, Vall d’Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain
Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain

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factor for dementia, promotes neurocognitive function and regulation metabolic processes ( 4 ). Thyroid dysfunction, including clinical hyperthyroidism, subclinical hyperthyroidism, subclinical hypothyroidism, and clinical hypothyroidism, has been

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-21-0047
Volume/Issue:
Volume 10: Issue 4
Open access
Xin He Laboratory of Functional Medicine, Division of Chronic Non-communicable Diseases and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China

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Qin Yan Laboratory of Functional Medicine, Division of Chronic Non-communicable Diseases and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China

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Chazhen Liu Laboratory of Functional Medicine, Division of Chronic Non-communicable Diseases and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China

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Zhengyuan Wang Department of Nutrition Hygiene, Division of Health Risk Factor Monitoring and Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China

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Ping Liao Laboratory of Functional Medicine, Division of Chronic Non-communicable Diseases and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China

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Tong Liu Laboratory of Functional Medicine, Division of Chronic Non-communicable Diseases and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China

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Zehuan Shi Department of Nutrition Hygiene, Division of Health Risk Factor Monitoring and Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China

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Qi Song Department of Nutrition Hygiene, Division of Health Risk Factor Monitoring and Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China

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Xueying Cui Department of Nutrition Hygiene, Division of Health Risk Factor Monitoring and Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China

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Wenjing Wang Laboratory of Functional Medicine, Division of Chronic Non-communicable Diseases and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China

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Jiajie Zang Department of Nutrition Hygiene, Division of Health Risk Factor Monitoring and Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China

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hyperthyroidism was defined as TSH concentration below the 2.5th percentile with an FT4 concentration above the 97.5thpercentile, while subclinical hyperthyroidism was defined as TSH concentration below the 2.5th percentile with an FT4 concentration within the

Article Type:
Research Article
Collections:
Thyroid
DOI:
https://doi.org/10.1530/EC-21-0599
Volume/Issue:
Volume 11: Issue 4
Open access
Till Ittermann Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany

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Rehman Mehmood Khattak Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
Department of Zoology, Islamia College Peshawar (CU), Peshawar, Pakistan

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Marcello R P Markus Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany

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Jens-Peter Kühn Institute of Radiology, University Hospital, Carl-Gustav-Carus University, Dresden, Germany

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Marie-Luise Kromrey Department of Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany

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Giovanni Targher Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Verona, Verona, Italy

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Antje Steveling Department of Internal Medicine A, University Medicine Greifswald, Greifswald, Germany

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Matthias Nauck Institute for Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, University Medicine, Greifswald, Germany

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Henry Völzke Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany

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results of our study may stress that not only subclinical hypothyroidism but also hyperthyroidism is associated with increased hepatic fat particularly in obese individuals. However, one has to be cautious with these findings, and our results have to be

Article Type:
Research Article
Collections:
Thyroid
DOI:
https://doi.org/10.1530/EC-21-0566
Volume/Issue:
Volume 11: Issue 2
Open access
Akinori Sairaku Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan

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Yukiko Nakano Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan

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Yuko Uchimura Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan

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Takehito Tokuyama Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan

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Hiroshi Kawazoe Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan

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Yoshikazu Watanabe Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan

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Hiroya Matsumura Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan

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Yasuki Kihara Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan

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), we hypothesized that subclinical hypothyroidism was associated with an increased LA pressure. It is well known that hyperthyroidism often causes atrial fibrillation (AF) ( 1 , 2 ), and recently, a study ( 10 ) has provided evidence supporting the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-16-0012
Volume/Issue:
Volume 5: Issue 3
Open access
Stine Linding Andersen Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark

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Stig Andersen Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
Department of Geriatrics, Aalborg University Hospital, Aalborg, Denmark

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failure. These early observations have later been corroborated in large observational studies including non-exposed controlled groups ( 52 , 53 , 54 ). On the other hand, subclinical hyperthyroidism has not been associated with a risk of pregnancy

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-20-0518
Volume/Issue:
Volume 10: Issue 2
Open access
Marek Niedziela Department of Pediatric Endocrinology and Rheumatology, Institute of Pediatrics, Karol Jonscher’s Clinical Hospital, Poznan University of Medical Sciences, Poznan, Poland

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-Albright syndrome (MAS), a sporadic genetic disease, is caused by an activating mutation of GNAS1 for the Gs alpha membrane-associated protein, mediating the TSH-induced and other hormone-induced activation of adenylyl cyclase; subclinical hyperthyroidism can be

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-21-0191
Volume/Issue:
Volume 10: Issue 11
Open access
Simona Censi Endocrinology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy

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Laura Salmaso Clinical Governance Unit, Azienda Zero, Veneto Region, Italy

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Filippo Ceccato Endocrinology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy

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Jacopo Manso Endocrinology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy
Pediatric Endocrinology Unit, Department of Women's and Children's Health, Padua University Hospital, Padova, Italy

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Ugo Fedeli Clinical Governance Unit, Azienda Zero, Veneto Region, Italy

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Mario Saia Clinical Governance Unit, Azienda Zero, Veneto Region, Italy

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Caterina Mian Endocrinology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy

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associated with nodular goiter is quite well understood and thus the decrease in nodular goiter incidence with the improvement of iodine status is expected. The mechanism is slow and could take decades to go from euthyroidism to subclinical hyperthyroidism

Article Type:
Research Article
Collections:
Thyroid
DOI:
https://doi.org/10.1530/EC-23-0292
Volume/Issue:
Volume 12: Issue 12
Open access