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during prolonged (i.e. 1 h) moderate intensity exercise, in patients with Pompe disease. We used cycle-ergometer exercise and stable isotope methodology in combination with indirect calorimetry to determine glucose, glycerol, and fatty acid metabolism

insulin resistant groups, into similar observations in a T2DM cohort. Using an integrated, whole-body approach, stable isotope tracers to differentiate between changes in hepatic and peripheral insulin sensitivity of glucose uptake, body composition

hepatic DNL to a greater extent than consumption of the same amount of either glucose or fructose alone ( 65 , 66 , 67 , 68 ). Metabolic studies, utilising stable-isotope labelled fructose, have demonstrated that the contribution of ingested fructose to

, Analytical Technologies in the Biomedical and Life Sciences 883–884 2012 50 – 58 . ( doi:10.1016/j.jchromb.2011.08.027 ). 27 Wang S Cyronak M Yang E . Does a stable isotopically labeled internal standard always correct analyte response? A matrix effect

, coefficients of variation (CVs) for LRa and Lox are 3.5 and 6.1% respectively ( 18 ). Hepatic urea production The rate of urea production was measured by the urea turnover technique using stable isotope methodology with 15 N 2 -Urea as tracer, as

appropriate informed consent. Healthy participants were determined by screening assessments and absence of evidence of any active or chronic disease following a detailed medical and surgical history. Healthy participants had stable body weight prior to testing

should be performed in a pH-stable environment, as acidosis or alkalosis could cause respectively elevated or suppressed levels of ionized calcium ( 21 ). However, this measurement is of high cost and not widely available ( 11 ). For the diagnosis of

function and the procedures and results regarding this part have been previously described (6) . In summary, the protocol involved blood sampling, infusions of radioactive isotopes, and a prior ingestion of small doses lithium. Volunteers arrived at the

central nervous system. This signalling allows a relatively stable body weight to be maintained and in most cases of obesity a surfeit of leptin is found due to leptin resistance ( 5 ). Leptin has a number of diverse roles in the periphery, many of them

measurement. To achieve a good performance, laboratories are required to have 75% of assessable results within ±25% of the true values from DEQAS. The accurate measurement of 25 hydroxyvitamin D3 (25OHD3) status was carried out by isotope dilution mass