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Nicolai Preisler, Pascal Laforêt, Karen Lindhardt Madsen, Edith Husu, Christoffer Rasmus Vissing, Gitte Hedermann, Henrik Galbo, Christopher Lindberg, and John Vissing

during prolonged (i.e. 1 h) moderate intensity exercise, in patients with Pompe disease. We used cycle-ergometer exercise and stable isotope methodology in combination with indirect calorimetry to determine glucose, glycerol, and fatty acid metabolism

Open access

C L Bodinham, L Smith, E L Thomas, J D Bell, J R Swann, A Costabile, D Russell-Jones, A M Umpleby, and M D Robertson

insulin resistant groups, into similar observations in a T2DM cohort. Using an integrated, whole-body approach, stable isotope tracers to differentiate between changes in hepatic and peripheral insulin sensitivity of glucose uptake, body composition

Open access

Leanne Hodson and Fredrik Karpe

hepatic DNL to a greater extent than consumption of the same amount of either glucose or fructose alone ( 65 , 66 , 67 , 68 ). Metabolic studies, utilising stable-isotope labelled fructose, have demonstrated that the contribution of ingested fructose to

Open access

Paal Methlie, Steinar Hustad, Ralf Kellman, Bjørg Almås, Martina M Erichsen, Eystein S Husebye, and Kristian Løvås

, Analytical Technologies in the Biomedical and Life Sciences 883–884 2012 50 – 58 . ( doi:10.1016/j.jchromb.2011.08.027 ). 27 Wang S Cyronak M Yang E . Does a stable isotopically labeled internal standard always correct analyte response? A matrix effect

Open access

Teresa Lam, Mark McLean, Amy Hayden, Anne Poljak, Birinder Cheema, Howard Gurney, Glenn Stone, Neha Bahl, Navneeta Reddy, Haleh Shahidipour, and Vita Birzniece

, coefficients of variation (CVs) for LRa and Lox are 3.5 and 6.1% respectively ( 18 ). Hepatic urea production The rate of urea production was measured by the urea turnover technique using stable isotope methodology with 15 N 2 -Urea as tracer, as

Open access

T P Parikh, B Stolze, Y Ozarda, J Jonklaas, K Welsh, L Masika, M Hill, A DeCherney, and S J Soldin

appropriate informed consent. Healthy participants were determined by screening assessments and absence of evidence of any active or chronic disease following a detailed medical and surgical history. Healthy participants had stable body weight prior to testing

Open access

Maria Mizamtsidi, Constantinos Nastos, George Mastorakos, Roberto Dina, Ioannis Vassiliou, Maria Gazouli, and Fausto Palazzo

should be performed in a pH-stable environment, as acidosis or alkalosis could cause respectively elevated or suppressed levels of ionized calcium ( 21 ). However, this measurement is of high cost and not widely available ( 11 ). For the diagnosis of

Open access

Jeppe Skov, Jens Juul Holst, Jens Peter Gøtze, Jørgen Frøkiær, and Jens Sandahl Christiansen

function and the procedures and results regarding this part have been previously described (6) . In summary, the protocol involved blood sampling, infusions of radioactive isotopes, and a prior ingestion of small doses lithium. Volunteers arrived at the

Open access

Robert A Hart, Robin C Dobos, Linda L Agnew, Neil A Smart, and James R McFarlane

central nervous system. This signalling allows a relatively stable body weight to be maintained and in most cases of obesity a surfeit of leptin is found due to leptin resistance ( 5 ). Leptin has a number of diverse roles in the periphery, many of them

Open access

Federica Saponaro, Alessandro Saba, Sabina Frascarelli, Concetta Prontera, Aldo Clerico, Marco Scalese, Maria Rita Sessa, Filomena Cetani, Simona Borsari, Elena Pardi, Antonella Marvelli, Claudio Marcocci, Claudio Passino, and Riccardo Zucchi

measurement. To achieve a good performance, laboratories are required to have 75% of assessable results within ±25% of the true values from DEQAS. The accurate measurement of 25 hydroxyvitamin D3 (25OHD3) status was carried out by isotope dilution mass