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Marta Araujo-Castro Neuroendocrinology Unit, Department of Endocrinology and Nutrition, Hospital Universitario Ramón y Cajal, Instituto de Investigación Biomédica Ramón y Cajal, Madrid, Spain

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Héctor Pian Endocrinology Unit, Department of Pathology, Hospital Universitario Ramón y Cajal, Madrid, Spain

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Ignacio Ruz-Caracuel Endocrinology Unit, Department of Pathology, Hospital Universitario Ramón y Cajal, Madrid, Spain

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Alberto Acitores Cancela Neuroendocrinology Unit, Department of Neurosurgery, Hospital Universitario Ramón y Cajal, Madrid, Spain

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Eider Pascual-Corrales Neuroendocrinology Unit, Department of Endocrinology and Nutrition, Hospital Universitario Ramón y Cajal, Instituto de Investigación Biomédica Ramón y Cajal, Madrid, Spain

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Víctor Rodríguez Berrocal Neuroendocrinology Unit, Department of Neurosurgery, Hospital Universitario Ramón y Cajal, Madrid, Spain
Endoscopic Skull Base Unit, Department of Neurosurgery, Hospital Universitario HM Puerta del Sur, Madrid, Spain

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, tumor consistency was reported to be an important predictive factor since hard consistency could impede transsphenoidal resection, especially in macroadenomas ( 8 ). Preoperative somatostatin receptor ligands (SRLs) treatment is proven to reduce GH and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-20-0414
Volume/Issue:
Volume 10: Issue 1
Open access
Prishila Fookeerah Department of Diabetes and Endocrinology, Westmead Hospital, Sydney, Australia
School of Medicine, Western Sydney University, Sydney, Australia

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Winny Varikatt Department of Tissue Pathology and Diagnostic Oncology, Westmead Hospital, Sydney, Australia
Westmead Clinical School, University of Sydney, Sydney, Australia

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Meena Shingde Department of Tissue Pathology and Diagnostic Oncology, Westmead Hospital, Sydney, Australia
Westmead Clinical School, University of Sydney, Sydney, Australia

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Mark A J Dexter Westmead Clinical School, University of Sydney, Sydney, Australia
Department of Neurosurgery, Westmead Hospital, Sydney, Australia

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Mark McLean Department of Diabetes and Endocrinology, Westmead Hospital, Sydney, Australia
School of Medicine, Western Sydney University, Sydney, Australia

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patient with mild biochemical persistence was treated with a somatostatin receptor ligand (SRL) resulting in normalisation of IGF-1. Of the two residual macrotumours, one was lost to follow-up and the other was managed with SRL with subsequent

Article Type:
Research Article
Collections:
Pituitary and Hypothalamus
DOI:
https://doi.org/10.1530/EC-23-0328
Volume/Issue:
Volume 12: Issue 11
Open access
Erik Rösner Institute of Pharmacology and Toxicology, Jena University Hospital, Jena, Germany

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Daniel Kaemmerer Department of General and Visceral Surgery, Zentralklinik Bad Berka, Bad Berka, Germany

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Elisa Neubauer Institute of Pharmacology and Toxicology, Jena University Hospital, Jena, Germany

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Jörg Sänger Laboratory of Pathology and Cytology Bad Berka, Bad Berka, Germany

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Amelie Lupp Institute of Pharmacology and Toxicology, Jena University Hospital, Jena, Germany

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-8) for 16 min at 600 W and incubated with primary anti-PD-L1 antibody overnight at 4°C. To stain somatostatin receptors (SST) 1, 2, 3, 4, and 5, CXC motif chemokine receptor 4 (CXCR4), chromogranin A (CgA), and the proliferation marker Ki-67, the same

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-20-0540
Volume/Issue:
Volume 10: Issue 2
Open access
Peter Wolf Université Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Service d’Endocrinologie et des Maladies de la Reproduction, Centre de Référence des Maladies Rares de l’Hypophyse, Le Kremlin-Bicêtre, France
Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria

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Alexandre Dormoy Université Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Service d’Endocrinologie et des Maladies de la Reproduction, Centre de Référence des Maladies Rares de l’Hypophyse, Le Kremlin-Bicêtre, France

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Luigi Maione Université Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Service d’Endocrinologie et des Maladies de la Reproduction, Centre de Référence des Maladies Rares de l’Hypophyse, Le Kremlin-Bicêtre, France

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Sylvie Salenave Université Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Service d’Endocrinologie et des Maladies de la Reproduction, Centre de Référence des Maladies Rares de l’Hypophyse, Le Kremlin-Bicêtre, France

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Jacques Young Université Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Service d’Endocrinologie et des Maladies de la Reproduction, Centre de Référence des Maladies Rares de l’Hypophyse, Le Kremlin-Bicêtre, France

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Peter Kamenický Université Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Service d’Endocrinologie et des Maladies de la Reproduction, Centre de Référence des Maladies Rares de l’Hypophyse, Le Kremlin-Bicêtre, France

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Philippe Chanson Université Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Service d’Endocrinologie et des Maladies de la Reproduction, Centre de Référence des Maladies Rares de l’Hypophyse, Le Kremlin-Bicêtre, France

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pegvisomant both improve insulin sensitivity ( 6 ), glucose metabolism may improve or worsen when patients are treated with first-generation somatostatin receptor ligands (SRLs), octreotide and lanreotide ( 7 , 8 , 9 , 10 ). Pasireotide is a somatostatin

Article Type:
Research Article
Collections:
Metabolic Syndrome and Diabetes
DOI:
https://doi.org/10.1530/EC-22-0296
Volume/Issue:
Volume 11: Issue 12
Open access
Sara Storvall Department of Endocrinology, Abdominal Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

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Helena Leijon Department of Pathology and Huslab, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

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Eeva Ryhänen Department of Endocrinology, Abdominal Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

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Johanna Louhimo Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

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Caj Haglund Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

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Camilla Schalin-Jäntti Department of Endocrinology, Abdominal Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

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Johanna Arola Department of Pathology and Huslab, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

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scarce. Ligand binding to somatostatin receptors induces receptor internalization by endocytosis for the lysosomal regrading or recycling of the receptor to the plasma membrane ( 36 , 37 ). This could represent one mechanism explaining the cytoplasmic

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0260
Volume/Issue:
Volume 8: Issue 8
Open access
Bernardo Maia Neuroendocrinology Research Center/Endocrinology Division – Medical School and Hospital Universitário Clementino Fraga Filho – Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

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Leandro Kasuki Neuroendocrinology Research Center/Endocrinology Division – Medical School and Hospital Universitário Clementino Fraga Filho – Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
Neuroendocrinology Division – Instituto Estadual do Cérebro Paulo Niemeyer, Rio de Janeiro, Brazil
Endocrinology Division – Hospital Federal de Bonsucesso, Rio de Janeiro Brazil

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Mônica R Gadelha Neuroendocrinology Research Center/Endocrinology Division – Medical School and Hospital Universitário Clementino Fraga Filho – Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
Neuroendocrinology Division – Instituto Estadual do Cérebro Paulo Niemeyer, Rio de Janeiro, Brazil
Neuropatology and Molecular Genetics Laboratory – Instituto Estadual do Cérebro Paulo Niemeyer, Rio de Janeiro, Brazil

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patients have clinical contraindications or refuse to be submitted to surgery ( 4 , 10 ). Currently, there are three classes available for the treatment of acromegaly: somatostatin receptor ligands (SRLs), dopamine agonists, and GH receptor antagonist ( 4

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-20-0433
Volume/Issue:
Volume 9: Issue 12
Open access
Adrian F Daly Department of Endocrinology, Centre Hospitalier Universitaire (CHU) de Liège, Liège Université, Domaine Universitaire du Sart-Tilman, Liège, Belgium

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Liliya Rostomyan Department of Endocrinology, Centre Hospitalier Universitaire (CHU) de Liège, Liège Université, Domaine Universitaire du Sart-Tilman, Liège, Belgium

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Daniela Betea Department of Endocrinology, Centre Hospitalier Universitaire (CHU) de Liège, Liège Université, Domaine Universitaire du Sart-Tilman, Liège, Belgium

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Jean-François Bonneville Department of Endocrinology, Centre Hospitalier Universitaire (CHU) de Liège, Liège Université, Domaine Universitaire du Sart-Tilman, Liège, Belgium

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Chiara Villa Department of Endocrinology, Centre Hospitalier Universitaire (CHU) de Liège, Liège Université, Domaine Universitaire du Sart-Tilman, Liège, Belgium
Department of Pathological Cytology and Anatomy, Foch Hospital, Paris, France

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Natalia S Pellegata Institute for Diabetes and Cancer, Helmholtz Zentrum München, Neuherberg, Germany

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Beatrice Waser Division of Cell Biology and Experimental Cancer Research, Institute of Pathology, University of Bern, Bern, Switzerland

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Jean-Claude Reubi Division of Cell Biology and Experimental Cancer Research, Institute of Pathology, University of Bern, Bern, Switzerland

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Catherine Waeber Stephan Clinique Générale Ste-Anne, Fribourg, Switzerland

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Emanuel Christ Department of Endocrinology, Diabetology and Metabolism, University Hospital Basel, University of Basel, Basel, Switzerland

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Albert Beckers Department of Endocrinology, Centre Hospitalier Universitaire (CHU) de Liège, Liège Université, Domaine Universitaire du Sart-Tilman, Liège, Belgium

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Ferone D . Somatostatin receptor ligands in the treatment of acromegaly . Pituitary 2017 20 100 – 108 . ( https://doi.org/10.1007/s11102-017-0791-0 ) 10.1007/s11102-017-0791-0 28176162 17 Körner M Waser B Christ E Beck J Reubi JC . A critical

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0004
Volume/Issue:
Volume 8: Issue 4
Open access
Stefan Schulz
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Anika Mann
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Benjamin Novakhov
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Hugh D Piggins Institute of Pharmacology and Toxicology, Faculty of Life Sciences, Jena University Hospital, Friedrich Schiller University Jena, Drackendorfer Straße 1, D-07747 Jena, Germany

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Amelie Lupp
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Introduction The overexpression of receptors for small regulatory peptides, e.g. somatostatin, bombesin, vasoactive intestinal peptide (VIP) or pituitary adenylate cyclase-activating peptide (PACAP) provides the opportunity for effective clinical

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-14-0051
Volume/Issue:
Volume 4: Issue 1
Open access
Carolina Inda Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA)-CONICET-Partner Institute of the Max Planck Society, Buenos Aires, Argentina
DFBMC, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina

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Natalia G Armando Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA)-CONICET-Partner Institute of the Max Planck Society, Buenos Aires, Argentina

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Paula A dos Santos Claro Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA)-CONICET-Partner Institute of the Max Planck Society, Buenos Aires, Argentina

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Susana Silberstein Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA)-CONICET-Partner Institute of the Max Planck Society, Buenos Aires, Argentina
DFBMC, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina

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). Colored arrows show ligand-receptor interactions, with gray arrows indicating lower affinity. CRH binds to both receptors but with higher affinity to CRHR1. UCN1 is a high affinity ligand to both CRHR1 and CRHR2, whereas UCN2 and UCN3 are considered

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-17-0111
Volume/Issue:
Volume 6: Issue 6
Open access
G Giuffrida Endocrine Unit of University Hospital ‘AOU Policlinico G. Martino’, Messina, Italy
PhD School of Clinical and Experimental Biomedical Sciences, University of Messina, Messina, Sicily, Italy

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F Ferraù Endocrine Unit of University Hospital ‘AOU Policlinico G. Martino’, Messina, Italy
Department of Human Pathology ‘G. Barresi’, University of Messina, Messina, Sicily, Italy

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R Laudicella Nuclear Medicine Unit of University Hospital ‘AOU Policlinico G. Martino’, Messina, Italy
Department of Biomorphology, University of Messina, Messina, Sicily, Italy

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O R Cotta Department of Human Pathology ‘G. Barresi’, University of Messina, Messina, Sicily, Italy

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E Messina Endocrine Unit of University Hospital ‘AOU Policlinico G. Martino’, Messina, Italy

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F Granata Department of Biomorphology, University of Messina, Messina, Sicily, Italy
Neuroradiology Unit of University Hospital ‘AOU Policlinico G. Martino’, Messina, Italy

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F F Angileri Department of Biomorphology, University of Messina, Messina, Sicily, Italy
Neurosurgery Unit of University Hospital ‘AOU Policlinico G. Martino’, Messina, Italy

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A Vento Nuclear Medicine Unit of University Hospital ‘AOU Policlinico G. Martino’, Messina, Italy
Department of Biomorphology, University of Messina, Messina, Sicily, Italy

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A Alibrandi Department of Economics, University of Messina, Messina, Sicily, Italy

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S Baldari Nuclear Medicine Unit of University Hospital ‘AOU Policlinico G. Martino’, Messina, Italy
Department of Biomorphology, University of Messina, Messina, Sicily, Italy

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S Cannavò Endocrine Unit of University Hospital ‘AOU Policlinico G. Martino’, Messina, Italy
PhD School of Clinical and Experimental Biomedical Sciences, University of Messina, Messina, Sicily, Italy
Department of Human Pathology ‘G. Barresi’, University of Messina, Messina, Sicily, Italy

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-018-0865-7 ) 29344905 10.1007/s11102-018-0865-7 21 Cuevas-Ramos D Fleseriu M . Somatostatin receptor ligands and resistance to treatment in pituitary adenomas . Journal of Molecular Endocrinology 2014 52 R223 – R240 . ( https://doi.org/10.1530/JME-14-0011 ) 10

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0065
Volume/Issue:
Volume 8: Issue 5
Open access