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Sara Storvall, Helena Leijon, Eeva Ryhänen, Johanna Louhimo, Caj Haglund, Camilla Schalin-Jäntti and Johanna Arola

. Somatostatin receptors (SSTs) mediate the effects of the hormone somatostatin. These membrane-bound G-protein-coupled receptors mediate their effects by altering the levels of intracellular calcium and cAMP. They may also heterodimerize with each other, as well

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Myrtille Fouché, Yves Bouffard, Mary-Charlotte Le Goff, Johanne Prothet, François Malavieille, Pierre Sagnard, Françoise Christin, Davy Hayi-Slayman, Arnaud Pasquer, Gilles Poncet, Thomas Walter and Thomas Rimmelé

metastatic stages (>50% of cases at diagnosis) to prevent local complications and decrease tumour mass ( 9 , 10 ). They also recommend the use of somatostatin analogues due to their anti-proliferative effect on SB-NETs and their antisecretory effect against

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Cecilia Follin and Sven Karlsson

surgery necessitates chronic medical treatment. Current medical therapies available to treat acromegaly consist of somatostatin analogues (SSAs) and dopamine agonist (DA) medication, both of which act to suppress GH secretion from pituitary adenomas or

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Adrian F Daly, Liliya Rostomyan, Daniela Betea, Jean-François Bonneville, Chiara Villa, Natalia S Pellegata, Beatrice Waser, Jean-Claude Reubi, Catherine Waeber Stephan, Emanuel Christ and Albert Beckers

; in particular those with AIP mutations have a significantly lower hormonal response to first-generation, receptor subtype 2 (SST2) specific somatostatin analogs (octreotide and lanreotide) and have a decreased rate of tumor shrinkage on treatment

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Kjell Oberg, Eric Krenning, Anders Sundin, Lisa Bodei, Mark Kidd, Margot Tesselaar, Valentina Ambrosini, Richard P Baum, Matthew Kulke, Marianne Pavel, Jaroslaw Cwikla, Ignat Drozdov, Massimo Falconi, Nicola Fazio, Andrea Frilling, Robert Jensen, Klaus Koopmans, Tiny Korse, Dik Kwekkeboom, Helmut Maecke, Giovanni Paganelli, Ramon Salazar, Stefano Severi, Jonathan Strosberg, Vikas Prasad, Aldo Scarpa, Ashley Grossman, Annemeik Walenkamp, Mauro Cives, Irene Virgolini, Andreas Kjaer and Irvin M Modlin

of radioactive somatostatin analogs ( 10 ). Strategies include somatostatin receptor agonists, ‘targeted’ agents (mTOR inhibitors and VEGF antagonists), immunotherapy (interferon), cytotoxic chemotherapy, peptide receptor radionuclide therapy (PRRT

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Solène Castellnou, Alexandre Vasiljevic, Véronique Lapras, Véronique Raverot, Eudeline Alix, Françoise Borson-Chazot, Emmanuel Jouanneau, Gérald Raverot and Hélène Lasolle

corticotroph tumor (cabergoline or pasireotide). Pasireotide, a second-generation somatostatin analog, acting on somatostatin receptor (SST) subtype 1,2,3 and 5, is the only approved pituitary-targeting drug for the treatment of Cushing’s disease ( 11 , 12

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Hélène Lasolle, Amandine Ferriere, Alexandre Vasiljevic, Sandrine Eimer, Marie-Laure Nunes and Antoine Tabarin

surgeon ( 2 ). Medical management of acromegaly is used when surgery fails to control the disease or when surgery cannot be performed ( 3 ). First-generation long-acting somatostatin analogs (1gSRL) (octreotide LAR and lanreotide Autogel) are the most

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Adrian F Daly, David A Cano, Eva Venegas-Moreno, Patrick Petrossians, Elena Dios, Emilie Castermans, Alvaro Flores-Martínez, Vincent Bours, Albert Beckers and Alfonso Soto-Moreno

patients may be resistant to somatostatin analogs (SSA) that target the somatostatin receptor subtype 2 (SST2), while a small proportion of prolactinoma patients may not respond to labeled doses of dopamine agonists (DA). Hence, multimodal therapy involving

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Alberto Bongiovanni, Federica Recine, Flavia Foca, Valentina Fausti, Nada Riva, Greta Fabbri, Stefano Severi, Chiara Liverani, Alessandro De Vita, Chiara Spadazzi, Giacomo Miserocchi, Laura Mercatali, Dino Amadori and Toni Ibrahim

reported in <15% of cases ( 7 ). Treatment options for metastatic disease comprise liver surgery and/or locoregional and ablative therapies, somatostatin analogs, chemotherapy, targeted therapy and peptide receptor radionuclide therapy ( 8 ). Given the

Open access

Majunath R Goroshi, Swati S Jadhav, Anurag R Lila, Rajeev Kasaliwal, Shruti Khare, Chaitanya G Yerawar, Priya Hira, Uday Phadke, Hina Shah, Vikram R Lele, Gaurav Malhotra, Tushar Bandgar and Nalini S Shah

-photon emission computed tomography (SPECT)-based octreotide scintigraphy ( 123 I-Tyr-3-octreotide and 111 In-DTPA-pentetreotide) and more recently PET-based imaging such as 18 F-FDG PET/CT scan and 68 Ga-based somatostatin receptor (SSTR) positron emission