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Paula Bruna Araujo, Leandro Kasuki, Carlos Henrique de Azeredo Lima, Liana Ogino, Aline H S Camacho, Leila Chimelli, Márta Korbonits and Monica R Gadelha

.2)/Cell Marque, dilution 1:2000) to differentiate sparsely from densely granulated tumors. Nine frozen and three paraffin-embedded tissue samples of the enrolled patients were available for genetic screening for somatic AIP gene mutations. In cases

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Elena Pardi, Stefano Mariotti, Natalia S Pellegata, Katiuscia Benfini, Simona Borsari, Federica Saponaro, Liborio Torregrossa, Antonello Cappai, Chiara Satta, Marco Mastinu, Claudio Marcocci and Filomena Cetani

/168 in its C-terminal part. Although CDKN1B is considered to be a tumor suppressor gene, somatic loss-of-function mutations in this gene have rarely been detected in different cancers (17, 18, 19) . Conversely, loss or decreased expression of the P27

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Benjamin G Challis, Andrew S Powlson, Ruth T Casey, Carla Pearson, Brian Y Lam, Marcella Ma, Deborah Pitfield, Giles S H Yeo, Edmund Godfrey, Heok K Cheow, V Krishna Chatterjee, Nicholas R Carroll, Ashley Shaw, John R Buscombe and Helen L Simpson

, and associated with multiple endocrine neoplasia (MEN)-1 ( 1 ). Although single-copy deletion and somatic mutations in Menin have been identified in some sporadic insulinoma, it is now recognised that a recurrent somatic mutation in the transcription

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Tiemo S Gerber, Arno Schad, Nils Hartmann, Erik Springer, Ulrich Zechner and Thomas J Musholt

address the progression from well-differentiated thyroid carcinoma (WDTC) to PDTC. BRAF , TP53 , RAS While tumour-initiating somatic mutations leading to papillary thyroid carcinoma have been researched to a great extent, it remains uncertain

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Joakim Crona, Alberto Delgado Verdugo, Dan Granberg, Staffan Welin, Peter Stålberg, Per Hellman and Peyman Björklund

of underlying molecular mechanisms in the tumorigenesis of these diseases has increased dramatically during the last decade (1) . Up to 80% of all PCC and PGL could have either germline or somatic mutations (2, 3, 4) in one of the 11 hitherto known

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June Young Choi, Jin Wook Yi, Jun Hyup Lee, Ra-Yeong Song, Hyeongwon Yu, Hyungju Kwon, Young Jun Chai, Su-jin Kim and Kyu Eun Lee

, somatic mutations and gene expression data derived from RNA sequencing. Pathologic data were re-evaluated using scanned images of the paper-written pathologic documents provided by TCGA-associated hospitals. PTC subtype classification and MACIS scores were

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Jordyn Silverstein, Wesley Kidder, Susan Fisher, Thomas A Hope, Samantha Maisel, Dianna Ng, Jessica Van Ziffle, Chloe E Atreya and Katherine Van Loon

detected in three tumors, and both KRAS and TP53 mutations were detected in two tumors. A full summary of the types of somatic alterations is provided in Fig. 3 . Figure 3 Types of somatic alterations in CRC tumors obtained during the peri

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Huy Gia Vuong, Uyen N P Duong, Ahmed M A Altibi, Hanh T T Ngo, Thong Quang Pham, Hung Minh Tran, Greta Gandolfi and Lewis Hassell

Cancer . Hormones and Cancer 2016 7 165 – 177 . ( doi:10.1007/s12672-016-0256-3 ) 45 Landa I Ganly I Chan TA Mitsutake N Matsuse M Ibrahimpasic T Ghossein RA Fagin JA. Frequent somatic TERT promoter mutations in

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Dario de Biase, Federica Torricelli, Moira Ragazzi, Benedetta Donati, Elisabetta Kuhn, Michela Visani, Giorgia Acquaviva, Annalisa Pession, Giovanni Tallini, Simonetta Piana and Alessia Ciarrocchi

-PTCs) yielded a DNA amount and quality suitable for this analysis. Clinicopathological features of these 113 specimens are summarized in Supplementary Tables 1, 2, 3 and 4. A total of 133 somatic mutations were identified ( Fig. 1A and B and Supplementary

Open access

Filomena Cetani, Chiara Banti, Elena Pardi, Simona Borsari, Paolo Viacava, Paolo Miccoli, Liborio Torregrossa, Fulvio Basolo, Maria Rosa Pelizzo, Massimo Rugge, Gianmaria Pennelli, Guido Gasparri, Mauro Papotti, Marco Volante, Edda Vignali, Federica Saponaro and Claudio Marcocci

prevalence of PC (7) . Somatic inactivating mutations of the CDC73 gene have also been reported in up to 70% of apparently sporadic metastatic PC (8, 9, 10, 11, 12, 13, 14, 15, 16, 17) . Notably, in about one-third of patients, the mutations were germline