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digestive tract, including 59 with tumours located in the pancreas and 72 with lesions in the small intestine, caecum and appendix (midgut – the tumours originating from the central part of the archenteron) and in the colon (hindgut – tumours of the
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Introduction Neuroendocrine tumors (NETs) have increased in incidence with small intestine NETs (SINETs) being the most common and pancreatic NETs (PNETs), the third most common among gastroenteropancreatic (GEP) NETs per the SEER database
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–88 years (median age, 65 years). Lesions were located in the pancreas in 82 patients, in the small intestine in 75 patients, in the rectum in 14 patients and in the stomach in 8 patients. According to the current 2019 World Health Organization (WHO
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Wren Laboratories, Yale University School of Medicine, 35 NE Industrial Road, Branford, Connecticut, USA
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1 included 91 GEP-NETs (gastric, n =3; duodenum, n =1; pancreas, n =41; small intestine, n =40; appendix, n =3; and colorectum, n =3), 18 with an unknown primary, and 16 non-GEP-NETs. Histopathologically, 51% were G1, 27% G2, and 12% G3
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characteristics. Total group ( n =34) Gender Men 18 (52.9%) Women 16 (47.1%) Age, years (median, range) 62 (18–76) Primary tumor location Small intestine 33 (97.1%) Appendix 1 (2
Armed Forces College of Medicine, Cairo, Egypt
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endocrine tissue (including the thymus and excluding thyroid) (O/E = 38.3, 95% CI = 10.4–98.1); the small intestine (O/E = 8.9, 95% CI = 1.1–32); the liver (O/E = 8.7, 95% CI = 1.1–31.6); the stomach (O/E = 5, 95% CI = 1–14.5); nodal NHL (O/E = 3.8, 95% CI
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. Cohorts The study cohort comprised 258 NENs, including gastroenteropancreatic (GEP) NENs ( n = 215): pancreatic, PNENs, n = 67; small intestine (midgut), SINENs, n = 40; rectal, RNENs, n = 45; gastric, GNENs, n = 44; appendiceal, ANENs, n = 10
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) that were diagnosed with SI-NET and operated upon in Uppsala University Hospital. Twenty-three primary tumors, 21 mesenteric, 6 liver, and 1 extramesenteric lymph node metastases and 3 ‘normal’ small intestine tissue specimens were analyzed. Informed
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duodenum ( 15 ). And in the same year, Fleig described how blood from an isolated loop of the small intestine, into which acid was injected, increased bile-flow when transfused into another dog ( 16 ). Thus, already 1 year after Bayliss’ and Starling
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. The primary NETs were originating from the small intestine, pancreas, stomach, lung, or had an unknown origin. Patients were eligible for the study if they were medical treatment naive, were not obese, and had neither metabolic syndrome nor diabetes