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K G Samsom, L M van Veenendaal, G D Valk, M R Vriens, M E T Tesselaar and J G van den Berg

with metastatic small-intestinal NETs (SI-NETs), the carcinoid syndrome is common, which is characterised by diarrhoea, episodic flushing, bronchospasm and often carcinoid heart disease leading to right valvular dysfunction ( 4 ). Patients with non

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Elham Barazeghi, Per Hellman, Gunnar Westin and Peter Stålberg

Introduction Small intestinal neuroendocrine tumors (SI-NETs) arise from enterochromaffin cells in the gastrointestinal tract, which are small and slow-growing (Ki67 proliferation index is often <2%) tumors with annual incidence of 1 per 100

Open access

Merete Gedde-Dahl, Espen Thiis-Evensen, Andreas Myklebust Tjølsen, Kjerstin Skrede Mordal, Morten Vatn and Deidi S Bergestuen

with endocrine functions (1) . Small intestinal NETs often produce vasoactive substances that may result in the carcinoid syndrome, symptoms of which include flushing, diarrhea, carcinoid heart disease, and bronchospasm. The syndrome is almost

Open access

Annieke C G van Baar, Andrei Prodan, Camilla D Wahlgren, Steen S Poulsen, Filip K Knop, Albert K Groen, Jacques J Bergman, Max Nieuwdorp and Evgeni Levin

Introduction The small intestinal mucosa orchestrates a complex response to a range of internal and external stimuli. A pivotal role is played by enteroendocrine cells, whose dysfunction has been linked to metabolic diseases such as obesity

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Irvin M Modlin, Harry Aslanian, Lisa Bodei, Ignat Drozdov and Mark Kidd

cell tumors), as well as small intestinal ‘carcinoids’ (secretin, serotonin, and a variety of tachykinins) and colorectal lesions (enteroglucagon, GLP1, and pancreatic polypeptide (PP)). The conundrum of identifying a global marker for NETs therefore

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Aaron Lerner, Patricia Jeremias and Torsten Matthias

autoimmune diseases + + + Celiac disease CD is an autoimmune inflammatory disorder of the small intestine, triggered by the ingestion of prolamins contained in wheat, barley or rye, in genetically susceptible individuals. Its incidence

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Stefan Schulz, Anika Mann, Benjamin Novakhov, Hugh D Piggins and Amelie Lupp

Introduction The overexpression of receptors for small regulatory peptides, e.g. somatostatin, bombesin, vasoactive intestinal peptide (VIP) or pituitary adenylate cyclase-activating peptide (PACAP) provides the opportunity for effective clinical

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Mengxue Yang, Bowen Sun, Jianhui Li, Bo Yang, Jie Xu, Xue Zhou, Jie Yu, Xuan Zhang, Qun Zhang, Shan Zhou and Xiaohua Sun

genetic factors, environmental factors and immune factors ( 7 , 8 ). However, the exact mechanisms underlying the development of GD remain unclear. Segmented filamentous bacteria (SFB) may be effective inducers of Th17 cells in the intestinal mucosal

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Ashley K Clift, Omar Faiz, Robert Goldin, John Martin, Harpreet Wasan, Marc-Olaf Liedke, Erik Schloericke, Anna Malczewska, Guido Rindi, Mark Kidd, Irvin M Modlin and Andrea Frilling

permission, from Modlin IM, Gustafsson BI, Pavel M, Svejda B, Lawrence B & Kidd M (2010) A nomogram to assess small-intestinal neuroendocrine tumor (‘carcinoid’) survival, Neuroendocrinology , volume 92 , pages 143–157. Copyright 2010 Karger Publishers

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Jukka Koffert, Henri Honka, Jarmo Teuho, Saila Kauhanen, Saija Hurme, Riitta Parkkola, Vesa Oikonen, Andrea Mari, Andreas Lindqvist, Nils Wierup, Leif Groop and Pirjo Nuutila

showed that lipid and fat in combination with bile are the most potent flow inducers followed by glucose and proteins. In healthy individuals, the rate of gastric emptying is tightly regulated by small intestinal feedback, wherein acute hyperglycemia and