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the ventral (Hv) ( 22 ). The brain is regarded as the organ where kisspeptin genes primarily act, and the habenula mainly regulates circadian rhythm and stress response ( 23 ). The sexually dimorphic distribution of kiss -positive cells in the brain
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specifically, it is not the amount of circulating GH per se , but rather, the sexually dimorphic ultradian rhythms in plasma GH that regulate sex-dependent isoforms of CYP. Although there are some variations between species, in general, males secrete GH in
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mineralization in adulthood ( 15 ). Other studies could not confirm these data ( 16 , 17 ). In this review, we will first discuss how sex hormones induce sexually dimorphic pubertal bone mass acquisition. Next, we will review current knowledge on bone
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Division of Interventional Cognitive Neurology, Department of Neurology, Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
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animal data ( 50 ) and sexually dimorphic regulation of the MR- and gender-specific effects of aldosterone are at least described for other tissues ( 51 , 52 ). Chronic aldosterone excess seems not to influence immediate and delayed memory, cognitive
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-mediated effect between Y-1 cells and the in vivo mouse model at the transcriptome level. Sexually dimorphic adrenal gland and effects of Dex The histology and transcriptome of the adrenal gland are sexually dimorphic in mice ( 19 , 21 , 52 , 53
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the central nervous system, influencing the metabolism in a sexually dimorphic manner also at physiological levels ( 42 ). Androgens directly regulate the sympathetic nervous system output to white adipose tissue (WAT), and food intake, through the
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sexually dimorphic. These studies go in parallel with a recent work in 24 h fasted rats, where kisspeptin was able to suppress food intake ( 51 ), while this effect was not observed in ad libitum fed or 12 h fasted animals ( 19 , 52 ). Along this line
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, function, and potential molecular mechanisms of kisspeptin/KISS1R in the peripheral reproductive system can also contribute to our general knowledge of typical sexually dimorphic patterns of pubertal development. However, progress in this area will also
Department of Gynecology and Obstetrics, Wenzhou People’s Hospital, Wenzhou Women and Children Health, Wenzhou, Zhejiang, China
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then induces UPR response and apoptosis. Bidirectional modulation of insulin homeostasis regulated by TE in male and females is one of the most sexually dimorphic aspects of metabolic control ( 35 ). In male, the deficiency of testosterone result in
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and metabolic functions in the human liver, and testosterone maximizes the metabolic benefits of GH ( 2 , 14 ). Height and weight gain or body composition become sexually dimorphic around the time of puberty, when males more rapidly gain muscle and