Milena Kloter
Milena Kloter
Medical University Department of Medicine, Kantonsspital Aarau, Aarau, Switzerland
Faculty of Medicine, University of Basel, Basel, Switzerland
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Faculty of Medicine, University of Basel, Basel, Switzerland
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Claudia Gregoriano
Claudia Gregoriano
Medical University Department of Medicine, Kantonsspital Aarau, Aarau, Switzerland
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Ellen Haag
Ellen Haag
Medical University Department of Medicine, Kantonsspital Aarau, Aarau, Switzerland
Faculty of Medicine, University of Basel, Basel, Switzerland
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Faculty of Medicine, University of Basel, Basel, Switzerland
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Alexander Kutz
Alexander Kutz
Medical University Department of Medicine, Kantonsspital Aarau, Aarau, Switzerland
Faculty of Medicine, University of Basel, Basel, Switzerland
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Faculty of Medicine, University of Basel, Basel, Switzerland
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Beat Mueller
Beat Mueller
Medical University Department of Medicine, Kantonsspital Aarau, Aarau, Switzerland
Faculty of Medicine, University of Basel, Basel, Switzerland
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Faculty of Medicine, University of Basel, Basel, Switzerland
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Philipp Schuetz
Philipp Schuetz
Medical University Department of Medicine, Kantonsspital Aarau, Aarau, Switzerland
Faculty of Medicine, University of Basel, Basel, Switzerland
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Faculty of Medicine, University of Basel, Basel, Switzerland
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Introduction Systemic infection leading to sepsis contributes to a major portion of patients seeking care in the emergency department (ED) and the intensive care unit (ICU) ( 1 , 2 ). Sepsis has been defined as life-threatening organ
Margret J Einarsdottir
Margret J Einarsdottir
Department of Internal Medicine and Clinical Nutrition, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Department of Endocrinology, Sahlgrenska University Hospital, Gothenburg, Sweden
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Department of Endocrinology, Sahlgrenska University Hospital, Gothenburg, Sweden
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Penelope Trimpou
Penelope Trimpou
Department of Internal Medicine and Clinical Nutrition, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Department of Endocrinology, Sahlgrenska University Hospital, Gothenburg, Sweden
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Department of Endocrinology, Sahlgrenska University Hospital, Gothenburg, Sweden
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Gudmundur Johannsson
Gudmundur Johannsson
Department of Internal Medicine and Clinical Nutrition, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Department of Endocrinology, Sahlgrenska University Hospital, Gothenburg, Sweden
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Department of Endocrinology, Sahlgrenska University Hospital, Gothenburg, Sweden
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Oskar Ragnarsson
Oskar Ragnarsson
Department of Internal Medicine and Clinical Nutrition, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Department of Endocrinology, Sahlgrenska University Hospital, Gothenburg, Sweden
Wallenberg Center for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden
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Department of Endocrinology, Sahlgrenska University Hospital, Gothenburg, Sweden
Wallenberg Center for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden
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pain, nausea, vomiting, fever, and fatigue, which can be misdiagnosed as an infection or sepsis ( 1 , 2 ). Adrenal crisis-associated mortality is 6% ( 1 ). The incidence of adrenal crisis in patients with primary and secondary adrenal insufficiency is
Karim Gariani
Karim Gariani
Service of Endocrinology, Laboratory of Intensive Care, Department of Microbiology and Molecular Medicine, Diabetes, Hypertension and Nutrition
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Geneviève Drifte
Geneviève Drifte
Service of Endocrinology, Laboratory of Intensive Care, Department of Microbiology and Molecular Medicine, Diabetes, Hypertension and Nutrition
Service of Endocrinology, Laboratory of Intensive Care, Department of Microbiology and Molecular Medicine, Diabetes, Hypertension and Nutrition
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Service of Endocrinology, Laboratory of Intensive Care, Department of Microbiology and Molecular Medicine, Diabetes, Hypertension and Nutrition
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Irène Dunn-Siegrist
Irène Dunn-Siegrist
Service of Endocrinology, Laboratory of Intensive Care, Department of Microbiology and Molecular Medicine, Diabetes, Hypertension and Nutrition
Service of Endocrinology, Laboratory of Intensive Care, Department of Microbiology and Molecular Medicine, Diabetes, Hypertension and Nutrition
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Service of Endocrinology, Laboratory of Intensive Care, Department of Microbiology and Molecular Medicine, Diabetes, Hypertension and Nutrition
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Jérôme Pugin
Jérôme Pugin
Service of Endocrinology, Laboratory of Intensive Care, Department of Microbiology and Molecular Medicine, Diabetes, Hypertension and Nutrition
Service of Endocrinology, Laboratory of Intensive Care, Department of Microbiology and Molecular Medicine, Diabetes, Hypertension and Nutrition
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Service of Endocrinology, Laboratory of Intensive Care, Department of Microbiology and Molecular Medicine, Diabetes, Hypertension and Nutrition
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François R Jornayvaz
François R Jornayvaz
Service of Endocrinology, Laboratory of Intensive Care, Department of Microbiology and Molecular Medicine, Diabetes, Hypertension and Nutrition
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been shown that administration of a recombinant form of this hormone in obese mice and diabetic monkeys improves insulin sensitivity, body weight, and lipid profile (9, 10, 11, 12, 13, 14) . Sepsis represents a continuum beginning with a host
Yongli Fu
Yongli Fu
Department of Endocrinology, The Second Affiliated Hospital of Qiqihar Medical College, Qiqihar, Heilongjiang Province, People’s Republic of China
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Yaowu Sun
Yaowu Sun
Higher Education Research and Teaching Quality Assessment Center, Qiqihar Medical College, Qiqihar, Heilongjiang Province, People’s Republic of China
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Jiankun Zhang
Jiankun Zhang
Department of Clinical Laboratory, The Second Affiliated Hospital of Qiqihar Medical College, Qiqihar, Heilongjiang Province, People’s Republic of China
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Yu Cheng
Yu Cheng
Department of Nutrition and Food Hygiene, School of Public Health, Qiqihar Medical College, Qiqihar, Heilongjiang Province, People’s Republic of China
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mortality) or 3- to 6-month mortality, risk of hypoglycemia, sepsis and new need for dialysis. Trials that did not include the above mentioned outcomes or have sufficient data to calculate effect estimates were excluded from meta-analysis. Three
Britt J van Keulen
Britt J van Keulen
Department of Pediatric Endocrinology, Emma Children’s Hospital, Amsterdam University Medical Centers, location VUmc, Amsterdam, The Netherlands
Department of Pediatrics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Reproduction & Development Research Institute, de Boelelaan, Amsterdam, The Netherlands
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Department of Pediatrics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Reproduction & Development Research Institute, de Boelelaan, Amsterdam, The Netherlands
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Michelle Romijn
Michelle Romijn
Department of Pediatric Endocrinology, Emma Children’s Hospital, Amsterdam University Medical Centers, location VUmc, Amsterdam, The Netherlands
Department of Pediatrics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Reproduction & Development Research Institute, de Boelelaan, Amsterdam, The Netherlands
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Department of Pediatrics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Reproduction & Development Research Institute, de Boelelaan, Amsterdam, The Netherlands
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Bibian van der Voorn
Bibian van der Voorn
Department of Pediatric Endocrinology, Sophia Kinderziekenhuis, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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Marita de Waard
Marita de Waard
Emma Children’s Hospital, Amsterdam University Medical Centers, locations AMC and VUmc, Amsterdam, The Netherlands
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Michaela F Hartmann
Michaela F Hartmann
Steroid Research and Mass Spectrometry Unit, Laboratory for Translational Hormone Analytics, Pediatric Endocrinology & Diabetology, Center of Child and Adolescent Medicine, Justus-Liebig-University, Giessen, Germany
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Johannes B van Goudoever
Johannes B van Goudoever
Emma Children’s Hospital, Amsterdam University Medical Centers, locations AMC and VUmc, Amsterdam, The Netherlands
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Stefan A Wudy
Stefan A Wudy
Steroid Research and Mass Spectrometry Unit, Laboratory for Translational Hormone Analytics, Pediatric Endocrinology & Diabetology, Center of Child and Adolescent Medicine, Justus-Liebig-University, Giessen, Germany
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Joost Rotteveel
Joost Rotteveel
Department of Pediatric Endocrinology, Emma Children’s Hospital, Amsterdam University Medical Centers, location VUmc, Amsterdam, The Netherlands
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Martijn J J Finken
Martijn J J Finken
Department of Pediatric Endocrinology, Emma Children’s Hospital, Amsterdam University Medical Centers, location VUmc, Amsterdam, The Netherlands
Department of Pediatrics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Reproduction & Development Research Institute, de Boelelaan, Amsterdam, The Netherlands
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Department of Pediatrics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Reproduction & Development Research Institute, de Boelelaan, Amsterdam, The Netherlands
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), late-onset sepsis (LOS), bronchopulmonary dysplasia (BPD) and intraventricular hemorrhage (IVH), and more often require invasive respiratory support ( 2 , 4 , 5 ), than females. In childhood, male preterm infants had a greater odds of (major and minor
Zhou-Qing Kang
Zhou-Qing Kang
Department of Nursing, Jin Qiu Hospital of Liaoning Province, Geriatric Hospital of Liaoning Province, Shenyang, Liaoning Province, China
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Jia-Ling Huo
Jia-Ling Huo
Department of Respiratory Medicine, Jin Qiu Hospital of Liaoning Province, Geriatric Hospital of Liaoning Province, Shenyang, Liaoning Province, China
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Xiao-Jie Zhai
Xiao-Jie Zhai
Department of Nursing, Jin Qiu Hospital of Liaoning Province, Geriatric Hospital of Liaoning Province, Shenyang, Liaoning Province, China
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infection, sepsis, pneumonia and urinary infection), acute kidney injury, atrial fibrillation and myocardial infarction. Furthermore, tight glucose control was grouped into two intensities: very tight glucose control (upper level of perioperative glucose
Ermina Bach
Ermina Bach
Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
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Niels Møller
Niels Møller
Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
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Jens Otto L Jørgensen
Jens Otto L Jørgensen
Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
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Mads Buhl
Mads Buhl
The Neonatal Intensive Care Unit, Aarhus University Hospital, Aarhus, Denmark
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Holger Jon Møller
Holger Jon Møller
Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark
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including bacteremia and sepsis ( 2 , 3 , 4 ) and in inflammatory liver diseases ( 5 , 6 , 7 , 8 ). In vitro , lipopolysaccharide (LPS, endotoxin) induces ectodomain shedding of sCD163 by TLR-4 stimulation of the metalloproteinase TACE ( 9 ). LPS is a
Paul-Martin Holterhus
Paul-Martin Holterhus
Department of Pediatrics I, Pediatric Endocrinology and Diabetology, University Hospital of Schleswig-Holstein, UKSH, Campus Kiel and Christian Albrechts University, CAU, Kiel, Germany
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Alexandra Kulle
Alexandra Kulle
Department of Pediatrics I, Pediatric Endocrinology and Diabetology, University Hospital of Schleswig-Holstein, UKSH, Campus Kiel and Christian Albrechts University, CAU, Kiel, Germany
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Anne-Marie Till
Anne-Marie Till
Department of Pediatrics, Pediatric Hematology and Oncology, University Hospital of Schleswig-Holstein, UKSH, Campus Lübeck, Germany
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Caroline Stille
Caroline Stille
Department of Pediatrics, Pediatric Hematology and Oncology, University Hospital of Schleswig-Holstein, UKSH, Campus Lübeck, Germany
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Tabea Lamprecht
Tabea Lamprecht
Department of Pediatrics I, Pediatric Endocrinology and Diabetology, University Hospital of Schleswig-Holstein, UKSH, Campus Kiel and Christian Albrechts University, CAU, Kiel, Germany
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Simon Vieth
Simon Vieth
Department of Pediatrics I, Pediatric Hematology and Oncology, University Hospital of Schleswig-Holstein, UKSH, Campus Kiel and Christian-Albrechts-University, CAU, Kiel, Germany
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Melchior Lauten
Melchior Lauten
Department of Pediatrics, Pediatric Hematology and Oncology, University Hospital of Schleswig-Holstein, UKSH, Campus Lübeck, Germany
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response, is a significant health risk for affected children during acute febrile illness and may lead to increased morbidity and mortality ( 3 , 6 ). Glucocorticoid replacement regimens during stress episodes, for example, during infection and sepsis
K Amrein
K Amrein
Thyroid Endocrinology Osteoporosis Institute Dobnig, Graz, Austria
Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
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Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
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A Papinutti
A Papinutti
Department of General Surgery, Medical University of Graz, Graz, Austria
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E Mathew
E Mathew
Department of General Surgery, Medical University of Graz, Graz, Austria
Department of General Surgery, St. Elisabeth’s Hospital, Graz, Austria
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Department of General Surgery, St. Elisabeth’s Hospital, Graz, Austria
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G Vila
G Vila
Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
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D Parekh
D Parekh
Clinician Scientist in Critical Care, Birmingham, Acute Care Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK
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). Vitamin D deficiency has been shown to be associated with sepsis, acute respiratory distress syndrome and acute kidney injury ( 17 , 18 , 19 , 20 ) and three different meta-analyses confirm that patients with low vitamin D status have a longer ICU stay
Justyna Modrzynska
Justyna Modrzynska
Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Christine F Klein
Christine F Klein
Department of Cardiology, Herlev Gentofte Hospital, Herlev, Denmark
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Kasper Iversen
Kasper Iversen
Department of Clinical Medicine, Herlev Gentofte Hospital, Herlev, Denmark
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Henning Bundgaard
Henning Bundgaard
Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Bolette Hartmann
Bolette Hartmann
Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Maike Mose
Maike Mose
Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
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Nikolaj Rittig
Nikolaj Rittig
Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark
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Niels Møller
Niels Møller
Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark
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Jens J Holst
Jens J Holst
Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Nicolai J Wewer Albrechtsen
Nicolai J Wewer Albrechtsen
Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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trauma, inflammation and or sepsis ( 11 , 12 , 13 , 14 , 15 ). However, sequence homology between glucagon and GLP-1, close resemblance to other circulating proglucagon-derived peptides, and the fact that they circulate in low (picomolar
