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Caojie Liu, Qingguo Lv, Xinlei Chen, Guangcheng Ni, Liru Hu, Nanwei Tong and Yuwei Zhang

PPGL has been universally recognized and advocated to decrease intraoperative hypertension by preventing binding of catecholamines with α1 receptors ( 9 ). Clinically, two types of α-blockade are widely used: selective and non-selective. The effects of

Open access

Xinlei Chen, Liru Hu, Caojie Liu, Guangcheng Ni and Yuwei Zhang

management . European Journal of Surgical Oncology 2003 29 483 – 490 . ( ) 10.1016/S0748-7983(03)00071-4 12 Liu C Lv Q Chen X Ni G Hu L Zhang Y Tong N. Preoperative selective vs nonselective α-blockade

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Gavin P Vinson and Caroline H Brennan

melanocortin receptor blockade . Pain 2005 117 401 – 411 . ( doi:10.1016/j.pain.2005.07.003 ). 72 Ercil NE Galici R Kesterson RA . HS014, a selective melanocortin-4 (MC4) receptor antagonist, modulates the behavioral effects of morphine in

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Carolina Inda, Natalia G Armando, Paula A dos Santos Claro and Susana Silberstein

selectivity ( 33 ). The amino acid sequences of the intracellular and transmembrane domains of CRHRs present 80–85% identity. Several splice variants of CRHR1 have been identified but only one, CRHR1α, presents biological activity and is predominantly

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Elizabeth Micks, Greta B Raglan and Jay Schulkin

women at highest risk, is a critical barrier to progress towards optimizing women's reproductive health. Progesterone for preterm birth prevention In 2006, progesterone and 17α-hydroxyprogesterone caproate (17-OHPC) re-emerged as effective therapies for

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Michael Ulm, Arvind V Ramesh, Keely M McNamara, Suriyan Ponnusamy, Hironobu Sasano and Ramesh Narayanan

, 5α-reductase inhibitors, AR antagonists and androgen-synthesizing enzyme Cyp17A1 inhibitor ( 9 ). PCas that escape from these treatment options will be treated with chemotherapeutic agents such as cabazitaxel or docetaxel ( 10 ). LHRH agonists or

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Clarissa Souza Barthem, Camila Lüdke Rossetti, Denise P Carvalho and Wagner Seixas da-Silva

using a Luminata Forte Western HRP Substrate (Millipore), the membranes were incubated with 0.01% (w/v) sodium azide in 3% (v/v) BSA in TBS-T to inhibit the signal from the secondary antibody. Then, immunodetection was also performed for α-tubulin as a

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M L M Barreto-Chaves, N Senger, M R Fevereiro, A C Parletta and A P C Takano

( 10 , 51 , 110 , 113 , 114 , 115 , 116 , 117 ). AT1R silencing using a siRNA or AT1R blockade with a pharmacological antagonist (losartan) completely abolished TH-induced activation of the miR-208a/α-MHC, Akt/GSK3β/mTOR and NFkB signaling

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Lin Ji, Huan-Tong Wu, Xiao-Yan Qin and Rongfeng Lan

acid hydrophobic signal peptide and a short propeptide that ends with five adjacent arginine residues at the N-terminus. The C-terminal 25 amino acid region has an amphiphilic α-helix domain that can be associated with membranes at acidic pH (5

Open access

Giovanni Tulipano

-substrate phosphorylation ( 27 ). In primate pituitary cells, the authors investigated the involvement of other intracellular signalling pathways in the metformin-induced decrease of GH secretion by using selective pharmacological inhibitors. The blockade of PI3K, mTOR and