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Clinical characteristics of 138 Chinese female patients with idiopathic hypogonadotropic hypogonadism

Rui-yi Tang, Rong Chen, Miao Ma, Shou-qing Lin, Yi-wen Zhang, and Ya-ping Wang

as kg/m 2 . The Tanner score was used to assess baseline secondary sexual characteristics. Because our centre is a tertiary hospital, many patients were referred to our hospital after having received some hormone treatment. Information regarding

Open access

Effects of liraglutide on obesity-associated functional hypogonadism in men

M Jensterle, A Podbregar, K Goricar, N Gregoric, and A Janez

been poor responders to LSM, by means of reversal of FH and WR. The primary outcome measures were changes in testosterone, sexual function and gonadotropins. The secondary outcomes were measures of obesity and metabolic profile. Materials and

Open access

Sex-specific association between urinary kisspeptin and pubertal development

Rafaella Sales de Freitas, Thiago F A França, and Sabine Pompeia

involves neuroendocrine changes leading to maturation of the gonads, acceleration of growth in height, and development of secondary sexual characteristics. The kisspeptin peptides, produced by small groups of neurons in the hypothalamus, play a key role in

Open access

Optimal injection interval for testosterone undecanoate treatment of hypogonadal and transgender men

Nandini Shankara Narayana, Lam P Ly, Veena Jayadev, Carolyn Fennell, Sasha Savkovic, Ann J Conway, and David J Handelsman

sexual characteristics in males with hypogonadotropic hypogonadism . Journal of Sexual Medicine 2011 8 3471 – 3478 .

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Serum irisin levels increase in girls with central precocious puberty not dependent on BMI: a pilot study

Yanfei Chen, Mei Li, Binrong Liao, Jingzi Zhong, and Dan Lan

development of internal and external reproductive organs and secondary sexual characteristics before the age of 8 in girls and 9 in boys ( 1 ). In recent years, the age of puberty initiation has been declining all over the world, paralleled by the increasing

Open access

The role of kisspeptin and MKRN3 in the diagnosis of central precocious puberty in girls

Mei Li, Yanfei Chen, Binrong Liao, Jing Tang, Jingzi Zhong, and Dan Lan

luteinizing hormone (LH) and follicle stimulating hormone (FSH). Central precocious puberty (CPP) is a common pediatric endocrine disease due to premature reactivation of the HPG axis leading to the development of secondary sexual characteristics before the

Open access

Early expression of requisite developmental growth hormone imprinted cytochromes P450 and dependent transcription factors

Sarmistha Banerjee, Allison M Hayes, and Bernard H Shapiro

Introduction Sexual dimorphisms of some dozen or more hormone- and drug-metabolizing constituent cytochromes P450 (CYPs) observed in rats, humans, and many other species examined ( 1 ) are defined by two characteristics. (i) Following puberty

Open access

Beyond hormone replacement: quality of life in women with congenital hypogonadotropic hypogonadism

Shota Dzemaili, Jitske Tiemensma, Richard Quinton, Nelly Pitteloud, Diane Morin, and Andrew A Dwyer

induce secondary sexual characteristics and menses ( 4 ). Combined gonadotropin therapy or physiologic treatment with pulsatile GnRH are equally effective for inducing fertility in the vast majority of cases ( 10 ). Compared to fertile counterparts

Open access

Impact of transition on quality of life in patients with congenital adrenal hyperplasia diagnosed during childhood

Anne Bachelot, Magaly Vialon, Amandine Baptiste, Isabelle Tejedor, Caroline Elie, Michel Polak, Philippe Touraine, and the CRMERC study group

). Once growth is no longer a concern, a shift in treatment goals from optimization of growth and puberty to prevention of long-term adverse outcomes and optimization of fertility and sexual function is needed ( 5 , 6 , 7 , 8 , 9 , 10 ). The

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Sexual steroid hormone receptors profiles of ovarian carcinoma in Mexican women

María J Gómora, Flavia Morales-Vásquez, Enrique Pedernera, Delia Perez-Montiel, Horacio López-Basave, Antonio R Villa, Azucena Hernández-Martínez, Esteban Mena, and Carmen Mendez

that can increase the incidence as well as tumor aggressiveness ( 8 , 9 , 10 ). Sexual steroid hormones acting through their receptors regulate signaling pathways related to cell proliferation, epithelial–mesenchymal transition, apoptosis, cell