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Sylvia Thiele, Anke Hannemann, Maria Winzer, Ulrike Baschant, Heike Weidner, Matthias Nauck, Rajesh V Thakker, Martin Bornhäuser, Lorenz C Hofbauer and Martina Rauner

, studies have proposed a contribution of another Wnt inhibitor, sclerostin, to the pathophysiology of GIO. However, data are contradictory ( 11 , 12 , 13 , 14 ). Sclerostin is expressed mostly by osteocytes, making it a favorable candidate to

Open access

Athanasios D Anastasilakis, Marina Tsoli, Gregory Kaltsas and Polyzois Makras

bones, periostin serves both as a structural molecule of the bone matrix and a signaling molecule that stimulates osteoblast functions and bone formation through inhibition of sclerostin production and subsequent Wnt/β-catenin pathway stimulation ( 45

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Ann-Kristin Picke, Graeme Campbell, Nicola Napoli, Lorenz C Hofbauer and Martina Rauner

macrophages and reduced switch into anti-inflammatory M2 macrophages. (4) The network of osteocytes is reduced due to an increased apoptosis rate. They increase their expression of sclerostin, an inhibitor of osteoblast function, and RANKL, a promoter of

Open access

Elena Valassi, Natalia García-Giralt, Jorge Malouf, Iris Crespo, Jaume Llauger, Adolfo Díez-Pérez and Susan M Webb

-sorbent assay (Abcam), with a sensitivity <1 pg/mL and range between 1.23 and 900 pg/mL. Both serum Dickkopf-related protein 1 (DKK1) and sclerostin (SOST) concentrations were measured using an enzyme immunoassay (Biomedica, Vienna, Austria). Both intra- and

Open access

Martine Cohen-Solal, Thomas Funck-Brentano and Pablo Ureña Torres

bone resorption and BSAP, sclerostin, and procollagen type 1 N-terminal propeptide (P1NP) for bone formation ( 36 ). A more recent study revealed that BSAP, P1NP and TRAP5b were highly correlated to the level of bone remodeling assessed by bone biopsies

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Tingting Jia, Ya-nan Wang, Dongjiao Zhang and Xin Xu

10.1016/j.bbrc.2012.06.015 12 Tanaka K Yamaguchi T Kanazawa I Sugimoto T . Effects of high glucose and advanced glycation end products on the expressions of sclerostin and RANKL as well as apoptosis in osteocyte-like MLO-Y4-A2 cells . Biochemical