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Hershel Raff and Hariprasad Trivedi

Introduction The measurement of salivary cortisol has emerged as a first-line test in the evaluation of the hypothalamic–pituitary–adrenal (HPA) axis in humans and, in particular, for the diagnosis of endogenous hypercortisolism (Cushing

Open access

Filippo Ceccato, Elisa Selmin, Chiara Sabbadin, Miriam Dalla Costa, Giorgia Antonelli, Mario Plebani, Mattia Barbot, Corrado Betterle, Marco Boscaro, and Carla Scaroni

-HC (conv-HC) ( 10 , 11 , 12 ). AI treatment is further complicated by the absence of a universally accepted method to objectively evaluate the adequacy of GC substitutive therapy. We had recently proposed multiple salivary cortisol (F) collections to

Open access

Marcus Imamovic, Nils Bäcklund, Staffan Lundstedt, Göran Brattsand, Elisabeth Aardal, Tommy Olsson, and Per Dahlqvist

Introduction Timely diagnosis of endogenous Cushing's syndrome (CS) is important to reduce morbidity and mortality ( 1 , 2 , 3 ). Late-night salivary cortisol (LNSC) is an important screening instrument for CS with high sensitivity and

Open access

Marloes L P Langelaan, Jérôme M H Kisters, Mirjam M Oosterwerff, and Arjen-Kars Boer

Introduction The utility of measuring salivary cortisol has become increasingly popular in, for example, screening for Cushing’s syndrome or disease ( 1 , 2 ). Obtaining salivary samples is easy and patient friendly. An additional advantage

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Karim Gariani, Pedro Marques-Vidal, Gérard Waeber, Peter Vollenweider, and François R Jornayvaz

associated with IR and cardiovascular risk factors ( 13 ). Several studies have shown that individuals with glucose intolerance or T2DM exhibit a significantly higher level of chronic stress and hormonal stress responses ( 14 , 15 ). Salivary cortisol has

Open access

Sarah Ying Tse Tan, Hong Chang Tan, Ling Zhu, Lih Ming Loh, Dawn Shao Ting Lim, Du Soon Swee, Yoke Ling Chan, Huee Boon Lim, Shiau Lee Ling, En Jun Ou, Wynn Ee Teo, Xiao Ping Zhang, Hui Fen Goh, and Peng Chin Kek

, and calculations of the free cortisol index are limited by the measurement of cortisol-binding globulin and do not account for changes in binding affinity or albumin concentrations ( 12 , 13 ). Salivary cortisol is an alternative method to measure

Open access

Filippo Ceccato, Elisa Selmin, Giorgia Antonelli, Mattia Barbot, Andrea Daniele, Marco Boscaro, Mario Plebani, and Carla Scaroni

. Table 1 Basal and post-synacthen serum or salivary cortisol (F) and cortisone (E) levels. Data are expressed as means and s.e. Adrenal sufficient patients, n = 137 Central AI, n = 37 Normal HPA axis, n = 106 RAS, n

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Ramjan Sanas Mohamed, Biyaser Abuelgasim, Sally Barker, Hemanth Prabhudev, Niamh M Martin, Karim Meeran, Emma L Williams, Sarah Darch, Whitlock Matthew, Tricia Tan, and Florian Wernig

for CS including late-night salivary cortisol (LNSC), overnight dexamethasone suppression test (ODST), low-dose dexamethasone suppression test (LDDST) and 24-h urinary free cortisol (UFC) ( 1 , 2 , 3 ). A hallmark of CS is the disruption of the

Open access

Eva Olga Melin, Magnus Hillman, and Mona Landin-Olsson

with high midnight salivary cortisol (MSC) secretion (≥9.3 nmol/L) in these patients with T1D ( 22 ). We hypothesise that high MSC secretion contributes to hypertension and to treatment failure of antihypertensive drugs (AHDs). The main aims were to

Open access

S U Jayasinghe, S J Torres, C A Nowson, A J Tilbrook, and A I Turner

salivary alpha amylase and HR responses to the TSST. It was hypothesised that overweight/obese men aged 50–70 years will have a greater salivary cortisol, salivary alpha amylase and HR response to the TSST compared with age matched lean men. Subjects and