Hui Li
Hui Li
Department of Thyroid Surgery, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, Hunan, P. R. China.
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Peng Wu
Peng Wu
Department of Thyroid Surgery, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, Hunan, P. R. China.
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developing personalized treatment strategies tailored to individual tumor profiles. CRISPR/Cas9-based epigenome editing The CRISPR/Cas9 technology has enabled targeted studies of gene function in thyroid cancer ( 88 , 89 ). Researchers have used this
Dirk-Jan van Beek
Dirk-Jan van Beek
Department of Endocrine Surgical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
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Rachel S van Leeuwaarde
Rachel S van Leeuwaarde
Department of Endocrine Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
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Carolina R C Pieterman
Carolina R C Pieterman
Department of Endocrine Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
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Menno R Vriens
Menno R Vriens
Department of Endocrine Surgical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
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Gerlof D Valk
Gerlof D Valk
Department of Endocrine Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
Parelsnoer Institute, Utrecht, The Netherlands
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Parelsnoer Institute, Utrecht, The Netherlands
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the DutchMEN Study Group
the DutchMEN Study Group
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. Considering the complexity of MEN1, a longitudinal database with a disease-specific framework was a necessity. Whereas strategies for conducting randomized controlled trials on rare diseases have been described, research methods for observational studies are
Monia Cito
Monia Cito
Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy
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Silvia Pellegrini
Silvia Pellegrini
Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy
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Lorenzo Piemonti
Lorenzo Piemonti
Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy
Vita-Salute San Raffaele University, Milan, Italy
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Vita-Salute San Raffaele University, Milan, Italy
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Valeria Sordi
Valeria Sordi
Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy
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variability of isolated human islets and the need for lifelong immunosuppression. Different approaches using stem cells to support islet survival and function are being explored in preclinical and clinical settings ( 5 ). Now, the most advanced strategies to
Wenrui Wang
Wenrui Wang
Department of Endocrinology, The Second Hospital of Jilin University, Changchun, People’s Republic of China
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Chuan Zhang
Chuan Zhang
Department of Endocrinology, The Second Hospital of Jilin University, Changchun, People’s Republic of China
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metabolic, oxidative, and endoplasmic reticulum stresses; and on epigenetic changes due to chronic stress. We also review current antidiabetic strategies and potential future research directions that may identify a time window for alleviating the β
E T Aristizabal Prada
E T Aristizabal Prada
Department of Internal Medicine IV, Campus Grosshadern, University-Hospital, Ludwig-Maximilians-University of Munich, Munich, Germany
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C J Auernhammer
C J Auernhammer
Department of Internal Medicine IV, Campus Grosshadern, University-Hospital, Ludwig-Maximilians-University of Munich, Munich, Germany
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preclinical data into clinical treatments strategies in NETs of the GEP system. Declaration of interest C J A has received research contracts (Ipsen, Novartis), lecture honorarium (Ipsen, Novartis, Pfizer, Amgen, Roche, Falk) and advisory board
S C Clement
S C Clement
Department of Pediatrics, Emma Children’s Hospital, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital/ University Medical Center Utrecht, Utrecht, The Netherlands
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Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital/ University Medical Center Utrecht, Utrecht, The Netherlands
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W E Visser
W E Visser
Academic Center For Thyroid Disease, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
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C A Lebbink
C A Lebbink
Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital/ University Medical Center Utrecht, Utrecht, The Netherlands
Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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D Albano
D Albano
Department of Nuclear Medicine, University of Brescia and Spedali Civili of Brescia, Brescia, Italy
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H L Claahsen-van der Grinten
H L Claahsen-van der Grinten
Department of Pediatrics, Radboud University Medical Center, Amalia Children's Hospital, Nijmegen, The Netherlands
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A Czarniecka
A Czarniecka
The Oncologic and Reconstructive Surgery Clinic, M. Sklodowska-Curie National Research Institute of Oncology Gliwice Branch, Gliwice, Poland
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R P Dias
R P Dias
Department of Endocrinology and Diabetes, Birmingham Children’s Hospital, Birmingham Women’s, and Children’s NHS Foundation Trust, Birmingham, UK
Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
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Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
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M P Dierselhuis
M P Dierselhuis
Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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I Dzivite-Krisane
I Dzivite-Krisane
Department of Pediatric Endocrinology, Children's Clinical University Hospital, Riga, Latvia
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R Elisei
R Elisei
Endocrine Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
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A Garcia-Burillo
A Garcia-Burillo
Nuclear Medicine Department, Vall d'Hebron University Hospital, Barcelona, Spain
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L Izatt
L Izatt
Department of Clinical Genetics, Guy's and St Thomas’ NHS Foundation Trust, London, UK
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C Kanaka-Gantenbein
C Kanaka-Gantenbein
Division of Endocrinology, Diabetes, and Metabolism, First Department of Pediatrics National and Kapodistrian University of Athens Medical School, Aghia Sophia Children's Hospital, Athens, Greece
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H Krude
H Krude
Institute of Experimental Pediatric Endocrinology, Charité - Universitätsmedizin, Berlin, Germany
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L Lamartina
L Lamartina
Department of Endocrine Oncology, Gustave Roussy, Villejuif, France
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K Lorenz
K Lorenz
Department of Visceral, Vascular and Endocrine Surgery, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany
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M Luster
M Luster
Department of Nuclear Medicine, University Hospital Marburg, Marburg, Germany
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R Navardauskaitė
R Navardauskaitė
Department of Endocrinology, Lithuanian University of Health Sciences, Kaunas, Lithuania
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M Negre Busó
M Negre Busó
Nuclear Medicine Service - Institut de diagnòstic per la Imatge, Hospital Universitari de Girona Dr. Josep Trueta, Girona, Spain
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K Newbold
K Newbold
Thyroid Therapy Unit, The Royal Marsden NHS Foundation Trust Hospital, London, UK
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R P Peeters
R P Peeters
Academic Center For Thyroid Disease, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
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G Pellegriti
G Pellegriti
Endocrinology, Endocrinology Division, Garibaldi-Nesima Medical Center, Catania, Italy
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A Piccardo
A Piccardo
Department of Nuclear Medicine, EO Ospedali Galliera, Genoa, Italy
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A L Priego
A L Priego
Department of Medicine, Division of Endocrinology, Leiden, University medical Center, Leiden, The Netherlands
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A Redlich
A Redlich
Pediatric Oncology Department, Otto von Guericke University Children's Hospital, Magdeburg, Germany
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L de Sanctis
L de Sanctis
Regina Margherita Children Hospital - Department of Public Health and Pediatric Sciences, University of Torino, Torino, Italy
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M Sobrinho-Simões
M Sobrinho-Simões
University Hospital of São João, Medical Faculty and Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal
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A S P van Trotsenburg
A S P van Trotsenburg
Department of Pediatric Endocrinology, Emma Children’s Hospital, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands
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F A Verburg
F A Verburg
Department of Radiology & Nuclear Medicine, Erasmus MC Rotterdam, Rotterdam, The Netherlands
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M Vriens
M Vriens
Department of Endocrine Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
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T P Links
T P Links
Department of Endocrinology, University Medical Center Groningen, Groningen, The Netherlands
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S F Ahmed
S F Ahmed
Endocrinology, Endocrinology Division, Garibaldi-Nesima Medical Center, Catania, Italy
Developmental Endocrinology Research Group, Royal Hospital for Children, University of Glasgow, Glasgow, UK
Office for Rare Conditions, University of Glasgow, Glasgow, UK
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Developmental Endocrinology Research Group, Royal Hospital for Children, University of Glasgow, Glasgow, UK
Office for Rare Conditions, University of Glasgow, Glasgow, UK
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H M van Santen
H M van Santen
Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital/ University Medical Center Utrecht, Utrecht, The Netherlands
Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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primary malignancies ( 16 , 17 , 18 ). With current treatment strategies, the overall survival in pediatric patients with DTC is excellent. This excellent survival raises the question whether treatment may be given less ‘aggressively’ aiming to reduce
Michael C Velarde
Michael C Velarde
Institute of Biology, College of Science, University of the Philippines Diliman, Quezon, Metro Manila, Philippines
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Mikaela Erlinda M Bucu
Mikaela Erlinda M Bucu
Department of Obstetrics and Gynecology, College of Medicine, University of the Philippines Manila, Metro Manila, Philippines
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Maria Antonia E Habana
Maria Antonia E Habana
Department of Obstetrics and Gynecology, College of Medicine, University of the Philippines Manila, Metro Manila, Philippines
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endometriosis and funding support for endometriosis research in the region are still very limited. Clinical presentation and severity of endometriosis in Asian women Women with endometriosis often present with dysmenorrhea, severe chronic pelvic pain
Maximilian Bielohuby
Maximilian Bielohuby
Sanofi-Aventis Deutschland GmbH, R&D, Industriepark Höchst, Frankfurt, Germany
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Martin Bidlingmaier
Martin Bidlingmaier
Endocrine Research Laboratories, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Munich, Germany
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Uwe Schwahn
Uwe Schwahn
Sanofi-Aventis Deutschland GmbH, R&D, Industriepark Höchst, Frankfurt, Germany
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research purposes in laboratory rodents. The replacement of radioactivity by an enzymatic label in 1971 by Engvall and Perlmann (ELISA) ( 5 ) as well as by van Weemen and Schuurs (EIA) ( 6 ), and the associated increased handling convenience led to a boost
Petar Milovanovic
Petar Milovanovic
Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Laboratory for Anthropology and Skeletal Biology, Institute of Anatomy, Faculty of Medicine, University of Belgrade, Belgrade, Serbia
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Laboratory for Anthropology and Skeletal Biology, Institute of Anatomy, Faculty of Medicine, University of Belgrade, Belgrade, Serbia
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Björn Busse
Björn Busse
Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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development of preventive and therapeutic strategies to combat one of the most common health problems in aged individuals worldwide. Role of osteocytes in bone adaptation Currently, many bone properties are considered to be controlled or mediated by
Kaili Yang
Kaili Yang
Department of Medical Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
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Jiarui Li
Jiarui Li
Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, China
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Yuejuan Cheng
Yuejuan Cheng
Department of Medical Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
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Chunmei Bai
Chunmei Bai
Department of Medical Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
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unmet need for effective management strategies. Well-designed trials can improve the efficiency of clinical research, especially for uncommon malignancies like GEP-NENs. Efforts have been made to optimize the design of GEP-NEN trials in the past two
