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Prachi Bansal, Anurag Lila, Manjunath Goroshi, Swati Jadhav, Nilesh Lomte, Kunal Thakkar, Atul Goel, Abhidha Shah, Shilpa Sankhe, Naina Goel, Neelam Jaguste, Tushar Bandgar, and Nalini Shah

mortality ( 2 ). Transsphenoidal surgery (TSS) of pituitary adenoma is the primary treatment modality, with varying remission rates (52–96.6%) reported across different centres ( 3 ). Various demographic, biochemical, radiological and histopathological

Open access

Nidan Qiao

any advantages. Indeed, follow-up time in these studies was relatively short. It is unclear whether the proportions of remission and recurrence rates differ between endoscopic TS and microscopic TS. The best way to compare clinical outcomes between

Open access

Pablo Abellán-Galiana, Carmen Fajardo-Montañana, Pedro Riesgo-Suárez, Marcelino Pérez-Bermejo, Celia Ríos-Pérez, and José Gómez-Vela

Introduction Transsphenoidal surgery is the treatment of choice in Cushing’s disease (CD). Following removal of the pituitary adenoma, the remission rate varies between 25 and 100% (mean 77.8%, median 78.7%), and the recurrence rate ranges

Open access

Alberto Giacinto Ambrogio, Massimiliano Andrioli, Martina De Martin, Francesco Cavagnini, and Francesca Pecori Giraldi

Introduction First-line treatment of Cushing’s disease is surgical removal of the ACTH-secreting pituitary tumor and worldwide remission rates range from 60 to 80% ( 1 , 2 , 3 ). The tumor may recur, however, most often within two years of

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Muthiah Subramanian, Manu Kurian Baby, and Krishna G Seshadri

demonstrated in individuals without prior ATD usage. (Rc ATD =86%, Rc NOATD =94%, P <0.001). Patients who used antithyroid medications took a proportionately longer duration to achieve remission (TC NO ATD =102 days, TC ATD =253 days, P <0.001). The time to

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Jan Kvasnička, Ondřej Petrák, Tomas Zelinka, Judita Klímová, Barbora Kološová, Květoslav Novák, David Michalsky, Jiří Widimský, Jr., and Robert Holaj

Background: Pheochromocytomas (PHEO) are tumours with the ability to produce, metabolize and secrete catecholamines. Catecholamines overproduction leads to the decrease of longitudinal function of the left ventricle (LV) measured by speckle tracking echocardiography. Patients with PHEO have lower magnitude of global longitudinal strain (GLS) than patients with essential hypertension. GLS normalization is expected after resolution of catecholamine overproduction.

Methods: Twenty-four patients (14 females and 10 males) with recent diagnosis of PHEO have been examined before and one year after adrenalectomy. An echocardiographic examination including speckle tracking analysis with the evaluation of GLS and regional longitudinal strain (LS) in defined groups of LV segments (basal, mid-ventricular and apical) was performed.

Results: One year after adrenalectomy magnitude of GLS increased (−14.3 ± 1.8 to −17.7 ± 1.6 %; p < 0.001). When evaluating the regional LS, the most significant increase in the differences was evident in apical segment compared to mid-ventricular and basal segments of LV (-5.4 ± 5.0 vs. -1.9 ± 2.7 vs.-1.6 ± 3.8; p < 0.01).

Conclusions: In patients with PHEO, adrenalectomy leads to an improvement of subclinical LV dysfunction represented by increasing magnitude of GLS, which is the most noticeable in apical segments of LV.

Open access

Boni Xiang, Ran Tao, Xinhua Liu, Xiaoming Zhu, Min He, Zengyi Ma, Yehong Yang, Zhaoyun Zhang, Yiming Li, Zhenwei Yao, Yongfei Wang, and Hongying Ye

thyroid hormone changes was studied before and after remission of endogenous CS. In clinical practice, because of the lack of knowledge about this condition, some CS patients’ thyroid functions may be mistaken as evidence of hypothyroidism or

Open access

Marta Araujo-Castro, Héctor Pian, Ignacio Ruz-Caracuel, Alberto Acitores Cancela, Eider Pascual-Corrales, and Víctor Rodríguez Berrocal

active acromegaly are associated with higher mortality ( 1 ). Transsphenoidal surgery is generally considered the first-line treatment of choice in acro-megaly ( 1 ). However, although surgical remission is achieved in up to 100% of microadenomas in

Open access

Adriano N Cury, Verônica T Meira, Osmar Monte, Marília Marone, Nilza M Scalissi, Cristiane Kochi, Luís E P Calliari, and Carlos A Longui

countries, antithyroid drugs (ATDs) remain the first-line therapy (1, 2, 4, 5) , but they have several drawbacks, such as a high prevalence of side effects (20–30%), prolonged need for oral therapy, and low remission and high relapse rates during or after

Open access

Qinglei Yin, Zhou Jin, Yulin Zhou, Dalong Song, Chenyang Fu, FengJiao Huang, and Shu Wang

methods Patients Forty-five initial GD patients, 30 euthyroid GD patients, 12 TRAb negative-conversion GD (GD in remission) patients, and 30 age- and sex-matched healthy control donors (HC) were enrolled from Ruijin Hospital affiliated to Shanghai