Elham Barazeghi
Elham Barazeghi
Department of Surgical Sciences, Uppsala University, Uppsala University Hospital, Rudbeck Laboratory, Uppsala, Sweden
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Per Hellman
Per Hellman
Department of Surgical Sciences, Uppsala University, Uppsala University Hospital, Rudbeck Laboratory, Uppsala, Sweden
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Gunnar Westin
Gunnar Westin
Department of Surgical Sciences, Uppsala University, Uppsala University Hospital, Rudbeck Laboratory, Uppsala, Sweden
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Peter Stålberg
Peter Stålberg
Department of Surgical Sciences, Uppsala University, Uppsala University Hospital, Rudbeck Laboratory, Uppsala, Sweden
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regulatory region which contains a CpG island (CGI) spanning the promoter, exon 1 and part of intron 1 ( Fig. 5A ). The PTPRM gene has been shown to be methylated at the exon 1/intron 1 boundary in colon cancer ( 11 ). Therefore, by performing quantitative
Jessica S Jarmasz
Jessica S Jarmasz
Department of Physiology & Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada
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Yan Jin
Yan Jin
Department of Physiology & Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada
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Hana Vakili
Hana Vakili
Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
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Peter A Cattini
Peter A Cattini
Department of Physiology & Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada
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to the hGH-N promoter, where association of BMAL1 with this region was reduced as a result of HFD in 171hGH/CS TG mice ( 13 ). The circadian clock genes are also known to be involved in the homeostatic sleep process. The sleep homeostat keeps
Katherine A Bolton
Katherine A Bolton
Centre for Bioinformatics, Biomarker Discovery and Information-Based Medicine, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Priority Research Centre for Cancer, School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia
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Priority Research Centre for Cancer, School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia
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Kelly A Avery-Kiejda
Kelly A Avery-Kiejda
Centre for Bioinformatics, Biomarker Discovery and Information-Based Medicine, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Priority Research Centre for Cancer, School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia
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Priority Research Centre for Cancer, School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia
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Elizabeth G Holliday
Elizabeth G Holliday
Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia
Clinical Research Design, IT and Statistical Support Unit, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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Clinical Research Design, IT and Statistical Support Unit, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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John Attia
John Attia
Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia
Clinical Research Design, IT and Statistical Support Unit, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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Clinical Research Design, IT and Statistical Support Unit, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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Nikola A Bowden
Nikola A Bowden
Centre for Bioinformatics, Biomarker Discovery and Information-Based Medicine, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Priority Research Centre for Cancer, School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia
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Priority Research Centre for Cancer, School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia
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Rodney J Scott
Rodney J Scott
Centre for Bioinformatics, Biomarker Discovery and Information-Based Medicine, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Priority Research Centre for Cancer, School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia
Molecular Medicine, Pathology North, John Hunter Hospital, Newcastle, New South Wales, Australia
Discipline of Medical Genetics, School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, University Drive, Newcastle, New South Wales, Australia
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Priority Research Centre for Cancer, School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia
Molecular Medicine, Pathology North, John Hunter Hospital, Newcastle, New South Wales, Australia
Discipline of Medical Genetics, School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, University Drive, Newcastle, New South Wales, Australia
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the promoter region of the insulin-like growth factor-I (IGF-I) gene . European Journal of Epidemiology 2003 18 191 – 193 . ( doi:10.1023/A:1023309321705 ) 31 Rosen CJ Kurland ES Vereault D Adler RA Rackoff PJ Craig WY
Kristian Almstrup
Kristian Almstrup
Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Hanne Frederiksen
Hanne Frederiksen
Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Anna-Maria Andersson
Anna-Maria Andersson
Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Anders Juul
Anders Juul
Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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the observed variation in pubertal onset ( 8 , 9 ). We have recently described single genetic variants in the promoters of FSHR and FSHB , mediating the largest known effect on age at pubertal onset in girls, explaining nearly a year of pubertal
Dario de Biase
Dario de Biase
Department of Pharmacy and Biotechnology (Dipartimento di Farmacia e Biotecnologie) – Molecular Diagnostic Unit, Azienda USL di Bologna, University of Bologna, Bologna, Italy
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Federica Torricelli
Federica Torricelli
Laboratory of Translational Research, Azienda Unità Sanitaria Locale AUSL-IRCCS, Reggio Emilia, Italy
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Moira Ragazzi
Moira Ragazzi
Pathology Unit, Azienda Unità Sanitaria Locale AUSL-IRCCS, Reggio Emilia, Italy
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Benedetta Donati
Benedetta Donati
Laboratory of Translational Research, Azienda Unità Sanitaria Locale AUSL-IRCCS, Reggio Emilia, Italy
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Elisabetta Kuhn
Elisabetta Kuhn
Pathology Unit, Azienda Unità Sanitaria Locale AUSL-IRCCS, Reggio Emilia, Italy
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Michela Visani
Michela Visani
Department of Medicine (Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale) – Molecular Diagnostic Unit, Azienda USL di Bologna, University of Bologna School of Medicine, Bologna, Italy
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Giorgia Acquaviva
Giorgia Acquaviva
Department of Medicine (Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale) – Molecular Diagnostic Unit, Azienda USL di Bologna, University of Bologna School of Medicine, Bologna, Italy
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Annalisa Pession
Annalisa Pession
Department of Pharmacy and Biotechnology (Dipartimento di Farmacia e Biotecnologie) – Molecular Diagnostic Unit, Azienda USL di Bologna, University of Bologna, Bologna, Italy
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Giovanni Tallini
Giovanni Tallini
Department of Medicine (Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale) – Molecular Diagnostic Unit, Azienda USL di Bologna, University of Bologna School of Medicine, Bologna, Italy
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Simonetta Piana
Simonetta Piana
Pathology Unit, Azienda Unità Sanitaria Locale AUSL-IRCCS, Reggio Emilia, Italy
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Alessia Ciarrocchi
Alessia Ciarrocchi
Laboratory of Translational Research, Azienda Unità Sanitaria Locale AUSL-IRCCS, Reggio Emilia, Italy
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, 15, 16), SMAD4 (exons 6, 9, 10, 11, 12), TP53 (exons 4, 5, 6, 7, 8, 9), TERT (promoter region. The sequences obtained were analyzed using VariantStudio Software (Illumina Inc, San Diego, CA, USA) and the Integrative Genomics Viewer 2.3 (IGV
Ana P Estrada-Flórez
Ana P Estrada-Flórez
Genome Center and Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, California, USA
Grupo de Citogenética, Filogenia y Evolución de Poblaciones, Facultad de Ciencias y Facultad de Ciencias de la Salud, Universidad del Tolima, Ibagué, Tolima, Colombia
Facultad de Ciencias para la Salud, Universidad de Caldas, Manizales, Caldas, Colombia
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Grupo de Citogenética, Filogenia y Evolución de Poblaciones, Facultad de Ciencias y Facultad de Ciencias de la Salud, Universidad del Tolima, Ibagué, Tolima, Colombia
Facultad de Ciencias para la Salud, Universidad de Caldas, Manizales, Caldas, Colombia
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Mabel E Bohórquez
Mabel E Bohórquez
Grupo de Citogenética, Filogenia y Evolución de Poblaciones, Facultad de Ciencias y Facultad de Ciencias de la Salud, Universidad del Tolima, Ibagué, Tolima, Colombia
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Alejandro Vélez
Alejandro Vélez
Dinamica IPS, Medellín, Antioquia, Colombia
Hospital Pablo Tobón Uribe, Medellín, Antioquia, Colombia
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Hospital Pablo Tobón Uribe, Medellín, Antioquia, Colombia
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Carlos S Duque
Carlos S Duque
Hospital Pablo Tobón Uribe, Medellín, Antioquia, Colombia
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Jorge H Donado
Jorge H Donado
Hospital Pablo Tobón Uribe, Medellín, Antioquia, Colombia
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Gilbert Mateus
Gilbert Mateus
Hospital Federico Lleras Acosta, Ibagué, Tolima, Colombia
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Cesar Panqueba-Tarazona
Cesar Panqueba-Tarazona
Universidad Surcolombiana, Neiva, Huila, Colombia
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Guadalupe Polanco-Echeverry
Guadalupe Polanco-Echeverry
Genome Center and Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, California, USA
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Ruta Sahasrabudhe
Ruta Sahasrabudhe
Genome Center and Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, California, USA
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Magdalena Echeverry
Magdalena Echeverry
Grupo de Citogenética, Filogenia y Evolución de Poblaciones, Facultad de Ciencias y Facultad de Ciencias de la Salud, Universidad del Tolima, Ibagué, Tolima, Colombia
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Luis G Carvajal-Carmona
Luis G Carvajal-Carmona
Genome Center and Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, California, USA
Dinamica IPS, Medellín, Antioquia, Colombia
University of California Davis Comprehensive Cancer Center, Sacramento, California, USA
Fundación de Genética y Genómica, Medellín, Antioquia, Colombia
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Dinamica IPS, Medellín, Antioquia, Colombia
University of California Davis Comprehensive Cancer Center, Sacramento, California, USA
Fundación de Genética y Genómica, Medellín, Antioquia, Colombia
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eosin (H&E)- stained slides. We isolated the DNA from the demarcated regions using Qiagen DNeasy Blood & Tissue Kit and protocol. BRAF exon 15 and the TERT promoter region were amplified using previously reported primers ( 21 , 28 ) and Sanger
Erika Urbano Lima
Erika Urbano Lima
Biological Science Department, Thyroid Molecular Sciences Laboratory, Universidade Federal de São Paulo, São Paulo, Brazil
Structural and Functional Biology Program, Universidade Federal de São Paulo, São Paulo, Brazil
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Structural and Functional Biology Program, Universidade Federal de São Paulo, São Paulo, Brazil
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Ileana G S Rubio
Ileana G S Rubio
Biological Science Department, Thyroid Molecular Sciences Laboratory, Universidade Federal de São Paulo, São Paulo, Brazil
Structural and Functional Biology Program, Universidade Federal de São Paulo, São Paulo, Brazil
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Structural and Functional Biology Program, Universidade Federal de São Paulo, São Paulo, Brazil
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Joaquim Custodio Da Silva
Joaquim Custodio Da Silva
Department of Bio-regulation, Thyroid Study Laboratory, Health & Science Institute, Federal University of Bahia, Salvador, Brazil
Post-graduate Program in Interactive Processes of Organs and Systems, Health & Science Institute, Federal University of Bahia, Salvador, Brazil
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Post-graduate Program in Interactive Processes of Organs and Systems, Health & Science Institute, Federal University of Bahia, Salvador, Brazil
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Ana Luiza Galrão
Ana Luiza Galrão
Biological Science Department, Thyroid Molecular Sciences Laboratory, Universidade Federal de São Paulo, São Paulo, Brazil
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Danielle Pêssoa
Danielle Pêssoa
Department of Bio-regulation, Thyroid Study Laboratory, Health & Science Institute, Federal University of Bahia, Salvador, Brazil
Post-graduate Program in Interactive Processes of Organs and Systems, Health & Science Institute, Federal University of Bahia, Salvador, Brazil
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Post-graduate Program in Interactive Processes of Organs and Systems, Health & Science Institute, Federal University of Bahia, Salvador, Brazil
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Taise Cerqueira Oliveira
Taise Cerqueira Oliveira
Department of Bio-regulation, Thyroid Study Laboratory, Health & Science Institute, Federal University of Bahia, Salvador, Brazil
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Fabiane Carrijo
Fabiane Carrijo
Department of Bio-regulation, Thyroid Study Laboratory, Health & Science Institute, Federal University of Bahia, Salvador, Brazil
Post-graduate Program in Interactive Processes of Organs and Systems, Health & Science Institute, Federal University of Bahia, Salvador, Brazil
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Post-graduate Program in Interactive Processes of Organs and Systems, Health & Science Institute, Federal University of Bahia, Salvador, Brazil
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Igor Silva Campos
Igor Silva Campos
Department of Pathology, Sao Rafael Hospital, Salvador, Brazil
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Luciano Fonseca Espinheira
Luciano Fonseca Espinheira
Department of Pathology, Sao Rafael Hospital, Salvador, Brazil
Department of Anatomic Pathology & Legal Medicine, Bahia Federal Medical School, Federal University of Bahia, Salvador, Brazil
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Department of Anatomic Pathology & Legal Medicine, Bahia Federal Medical School, Federal University of Bahia, Salvador, Brazil
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Luiz Jose Sampaio
Luiz Jose Sampaio
Nuclear Medicine Department, Sao Rafael Hospital, Salvador, Brazil
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Claudio Rogerio Lima
Claudio Rogerio Lima
Head and Neck Surgery Department, Sao Rafael Hospital, Salvador, Brazil
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Janete Maria Cerutti
Janete Maria Cerutti
Structural and Functional Biology Program, Universidade Federal de São Paulo, São Paulo, Brazil
Division of Genetics, Department of Morphology and Genetics, Genetic Basis of Thyroid Tumors Laboratory, Paulista School of Medicine, Universidade Federal de São Paulo, São Paulo, Brazil
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Division of Genetics, Department of Morphology and Genetics, Genetic Basis of Thyroid Tumors Laboratory, Paulista School of Medicine, Universidade Federal de São Paulo, São Paulo, Brazil
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Helton Estrela Ramos
Helton Estrela Ramos
Department of Bio-regulation, Thyroid Study Laboratory, Health & Science Institute, Federal University of Bahia, Salvador, Brazil
Post-graduate Program in Interactive Processes of Organs and Systems, Health & Science Institute, Federal University of Bahia, Salvador, Brazil
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Post-graduate Program in Interactive Processes of Organs and Systems, Health & Science Institute, Federal University of Bahia, Salvador, Brazil
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affected by a growing number of DNA alterations in tumor-suppressor genes, especially via gene promoter methylation ( 4 ) causing a silencing of tumor-suppressor genes that are linked to apoptosis or DNA repair ( 5 , 6 ). A better understanding of such
Roberto Cosimo Melcangi
Roberto Cosimo Melcangi
Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milan, Italy
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Livio Casarini
Livio Casarini
Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy
Center for Genomic Research, University of Modena and Reggio Emilia, Modena, Italy
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Center for Genomic Research, University of Modena and Reggio Emilia, Modena, Italy
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Marco Marino
Marco Marino
Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy
Center for Genomic Research, University of Modena and Reggio Emilia, Modena, Italy
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Center for Genomic Research, University of Modena and Reggio Emilia, Modena, Italy
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Daniele Santi
Daniele Santi
Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy
Department of Medical Specialties, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy
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Department of Medical Specialties, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy
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Samantha Sperduti
Samantha Sperduti
Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy
Center for Genomic Research, University of Modena and Reggio Emilia, Modena, Italy
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Center for Genomic Research, University of Modena and Reggio Emilia, Modena, Italy
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Silvia Giatti
Silvia Giatti
Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milan, Italy
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Silvia Diviccaro
Silvia Diviccaro
Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milan, Italy
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Maria Grimoldi
Maria Grimoldi
Neurology Division, Papa Giovanni XXIII Hospital, Bergamo, Italy
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Donatella Caruso
Donatella Caruso
Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milan, Italy
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Guido Cavaletti
Guido Cavaletti
Experimental Neurology Unit and Milan Center for Neuroscience, School of Medicine and Surgery, University of Milano Bicocca, Monza, Italy
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Manuela Simoni
Manuela Simoni
Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy
Center for Genomic Research, University of Modena and Reggio Emilia, Modena, Italy
Department of Medical Specialties, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy
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Center for Genomic Research, University of Modena and Reggio Emilia, Modena, Italy
Department of Medical Specialties, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy
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, neuroinflammation and gut microbiota composition . Psychoneuroendocrinology 2019 99 . ( https://doi.org/10.1016/j.psyneuen.2018.09.021 ) 29 Araki R Nishida S Hiraki Y Matsumoto K Yabe T . DNA methylation of the GC box in the promoter region
Masatada Watanabe
Masatada Watanabe
Laboratory of Tissue Regeneration, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Shinagawa, Tokyo, Japan
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Shuji Ohno
Shuji Ohno
Division of Research for Pharmacy Students Education, Hoshi University, Shinagawa, Tokyo, Japan
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Hiroshi Wachi
Hiroshi Wachi
Laboratory of Tissue Regeneration, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Shinagawa, Tokyo, Japan
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the CYP19A1 gene transcript ( 9 ). This finding suggests that promoter I.4, 5′-upstream region of exon I.4, is activated in human skin fibroblasts. Figure 1 (A) Scheme of the multiple exons I in the human CYP19A1 gene- and tissue
Xuhua Mao
Xuhua Mao
Department of Clinical Laboratory, Yixing People’s Hospital, Yixing, Wuxi, Jiangsu, China
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Hucheng Chen
Hucheng Chen
Department of Nuclear Medicine, Nanjing Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu, China
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Junmin Tang
Junmin Tang
Department of Clinical Laboratory, Yixing People’s Hospital, Yixing, Wuxi, Jiangsu, China
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Liangliang Wang
Liangliang Wang
Department of Neurology, Yixing People’s Hospital Affiliated to Jiangsu University, Yixing, Wuxi, Jiangsu, China
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Tingting Shu
Tingting Shu
Department of Central Laboratory, Jiangsu Province Official Hospital, Nanjing, Jiangsu, China
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blood glucose levels ( 4 ). It is known that the mechanism by which gluco-toxicity inhibits insulin synthesis involves the loss of expression of pancreas duodenum homeobox-1 (Pdx-1), which acts as a critical regulator of insulin promoter activity ( 5
