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Introduction Polyuria (diuresis >3 l/day) in the absence of common causes, such as hypercalcemia, hyperglycemia, or relief of urinary tract obstruction, can be caused by diabetes insipidus (DI) or primary polydipsia (PP, also referred to as
Department of Clinical Research, University of Basel, Basel, Switzerland
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Department of Clinical Research, University of Basel, Basel, Switzerland
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Department of Clinical Research, University of Basel, Basel, Switzerland
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Department of Clinical Research, University of Basel, Basel, Switzerland
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Department of Clinical Research, University of Basel, Basel, Switzerland
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Central Laboratory, University Hospital Würzburg, Würzburg, Germany
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Leipzig University Medical Center, IFB Adiposity Diseases, Leipzig, Germany
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Department of Clinical Research, University of Basel, Basel, Switzerland
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Introduction Polyuria polydipsia syndrome is a common problem in clinical practice with the two main entities being primary polydipsia and central diabetes insipidus ( 1 ). While the pathomechanism of central diabetes insipidus is well known
Department of Clinical Research, University of Basel, Basel, Switzerland
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Central Laboratory, University Hospital Wuerzburg, Wuerzburg, Germany
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Leipzig University Medical Center, IFB Adiposity Diseases, Leipzig, Germany
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Department of Clinical Research, University of Basel, Basel, Switzerland
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older, had a baseline sodium level 135–145 mmol/L, and a euvolemic status. Exclusion criteria included pregnancy, a history or presence of PPS, which comprises all forms of DI and primary polydipsia (PP), any chronic or therapy-requiring diseases
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Centre for Cardiovascular Science, Queen’s Medical Research Unit, University of Edinburgh, Edinburgh, UK
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Introduction Primary hyperparathyroidism (PHPT) is a common endocrine condition with a prevalence of 0.1–1%, a female preponderance and a strong association with ageing ( 1 , 2 ). In the modern era, PHPT is often detected incidentally through
Institute of Endocrine and Metabolic Diseases of Shandong University, Jinan, China
Key Laboratory of Endocrine and Metabolic Diseases, Shandong Province Medicine & Health, Jinan, China
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Institute of Endocrine and Metabolic Diseases of Shandong University, Jinan, China
Key Laboratory of Endocrine and Metabolic Diseases, Shandong Province Medicine & Health, Jinan, China
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Institute of Endocrine and Metabolic Diseases of Shandong University, Jinan, China
Key Laboratory of Endocrine and Metabolic Diseases, Shandong Province Medicine & Health, Jinan, China
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Health Management Center, The Second Affiliated Hospital of Zhejiang Chinese Medicine University, Zhejiang, China
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Institute of Endocrine and Metabolic Diseases of Shandong University, Jinan, China
Key Laboratory of Endocrine and Metabolic Diseases, Shandong Province Medicine & Health, Jinan, China
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Institute of Endocrine and Metabolic Diseases of Shandong University, Jinan, China
Key Laboratory of Endocrine and Metabolic Diseases, Shandong Province Medicine & Health, Jinan, China
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Institute of Endocrine and Metabolic Diseases of Shandong University, Jinan, China
Key Laboratory of Endocrine and Metabolic Diseases, Shandong Province Medicine & Health, Jinan, China
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Institute of Endocrine and Metabolic Diseases of Shandong University, Jinan, China
Key Laboratory of Endocrine and Metabolic Diseases, Shandong Province Medicine & Health, Jinan, China
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Introduction In the 1970s, due to the popularization of serum calcium (Ca) examination, a novel type of primary hyperparathyroidism (PHPT) called asymptomatic PHPT (aPHPT) emerged. It lacks the typical clinical symptoms caused by excessive
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Department of Molecular Surgery and Medicine, Karolinska Institute, Stockholm, Sweden
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U-osmolality >100 mOsm/kg points to SIAD <200 mOsm/kg in primary polydipsia U-Na and U-K (spot-check) U-Na <15 mmol/L proves a reduced arterial blood volume, e.g. in exsiccosis, liver cirrhosis S-Kalium Hypokalemia is a risk
National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
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National Center for Neurological Disorders, Shanghai, China
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Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
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National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
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National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
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National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
Department of Pathology, Huashan Hospital, Shanghai Medical School, Shanghai, China
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National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
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National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
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National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
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Huashan Hospital institutional review board approved the study, and all of the patients gave their informed consent when their data were logged into the database. We recorded gender, age at diagnosis, symptoms (headache, visual defects, polydipsia and
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and other primary pituitary tumors (germinoma, chordoma, meningioma, etc.) were excluded. Information abstracted from patient records included tumor origin, primary pituitary clinical presentation, age, sex, type of treatment, presence of other
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Department of Medical Genetics, Cambridge University, Cambridge, UK
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Introduction Primary hyperparathyroidism (pHPT) is a common endocrine disorder with a prevalence of 1–4 per 1000 and a 3 to 1 female to male ratio ( 1 ). It is characterised by inappropriate and excessive secretion of parathyroid hormone (PTH
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Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark
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Steno Diabetes Center Aarhus (SDCA), Aarhus University Hospital, Aarhus, Denmark
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). The polyuria of PPS is characterized by a high output of hypotonic urine ( 2 ) and includes four conditions: arginine vasopressin (AVP) deficiency, nephrogenic diabetes insipidus, primary polydipsia, and gestational diabetes insipidus. The water