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Kathrin Zopf, Kathrin R Frey, Tina Kienitz, Manfred Ventz, Britta Bauer and Marcus Quinkler

AC might be influenced by the Bcl I polymorphism. Therefore, we included 72 patients with adrenal insufficiency (47 patients with primary adrenal insufficiency (PAI) and 25 patients with congenital adrenal hyperplasia (CAH)) in a prospective

Open access

Lia Ferreira, João Silva, Susana Garrido, Carlos Bello, Diana Oliveira, Hélder Simões, Isabel Paiva, Joana Guimarães, Marta Ferreira, Teresa Pereira, Rita Bettencourt-Silva, Ana Filipa Martins, Tiago Silva, Vera Fernandes, Maria Lopes Pereira and Adrenal Tumors Study Group of the Portuguese Society of Endocrinology

Introduction Addison disease (AD) or primary adrenal insufficiency (PAI) is a life-threatening disease that results from bilateral destruction or dysfunction of the adrenal cortex ( 1 ). PAI is a rare disease with a reported prevalence of

Open access

Kathrin R Frey, Tina Kienitz, Julia Schulz, Manfred Ventz, Kathrin Zopf and Marcus Quinkler

Introduction In states of adrenal insufficiency (AI), such as primary adrenal insufficiency (PAI) and congenital adrenal hyperplasia (CAH), glucocorticoids (GCs) are given in low doses as hormone replacement therapy. However, the daily intake

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Nilesh Lomte, Tushar Bandgar, Shruti Khare, Swati Jadhav, Anurag Lila, Manjunath Goroshi, Rajeev Kasaliwal, Kranti Khadilkar and Nalini S Shah

primary adrenal insufficiency: an Endocrine Society clinical practice guideline . Journal of Clinical Endocrinology and Metabolism 2016 101 364 – 389 . ( doi:10.1210/jc.2015-1710 ) 7 El-Hefnawy AS El Garba M Osman Y Eraky I El

Open access

Kamran Iqbal, Kate Halsby, Robert D Murray, Paul V Carroll and Robert Petermann

Introduction Adrenal insufficiency (AI) is a chronic, rare, potentially fatal condition. Primary AI (also known as Addison’s disease or hypoadrenalism) is caused by the loss of function of the adrenal cortex, whereas secondary AI results from

Open access

L M Mongioì, R A Condorelli, S La Vignera and A E Calogero

Introduction Adrenal insufficiency (AI) is a disease caused by either primary adrenal failure (Addison’s disease, over 90% due to autoimmune adrenalitis) ( 1 ) or by hypothalamic–pituitary impairment of the corticotropic axis alone or in

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Stephanie Burger-Stritt, Linda Bachmann, Max Kurlbaum and Stefanie Hahner

-0824) 14 Bornstein SR Allolio B Arlt W Barthel A Don-Wauchope A Hammer GD Husebye ES Merke DP Murad MH Stratakis CA , Diagnosis and treatment of primary adrenal insufficiency: an Endocrine Society clinical practice guideline . Journal of Clinical

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David J F Smith, Hemanth Prabhudev, Sirazum Choudhury and Karim Meeran

Introduction Adrenal insufficiency (AI) is caused either by primary adrenal failure or secondary impairment of the hypothalamic–pituitary–adrenal axis ( 1 ). Both result in glucocorticoid deficiency with additional impairment of

Open access

Ghazala Zaidi, Vijayalakshmi Bhatia, Saroj K Sahoo, Aditya Narayan Sarangi, Niharika Bharti, Li Zhang, Liping Yu, Daniel Eriksson, Sophie Bensing, Olle Kämpe, Nisha Bharani, Surendra Kumar Yachha, Anil Bhansali, Alok Sachan, Vandana Jain, Nalini Shah, Rakesh Aggarwal, Amita Aggarwal, Muthuswamy Srinivasan, Sarita Agarwal and Eesh Bhatia

#240300) ( 1 , 2 ). It is diagnosed by the presence of at least two of three major components: chronic mucocutaneous candidiasis (MCC), hypoparathyroidism (HP) and primary adrenal insufficiency (PAI) ( 3 , 4 , 5 , 6 , 7 ). In addition, it is

Open access

Filippo Ceccato, Elisa Selmin, Chiara Sabbadin, Miriam Dalla Costa, Giorgia Antonelli, Mario Plebani, Mattia Barbot, Corrado Betterle, Marco Boscaro and Carla Scaroni

Introduction Adrenal insufficiency (AI) is a rare endocrine disorder characterized by insufficient cortisol production, due to impaired ACTH or cortisol secretion, depicting secondary or primary AI (respectively SAI and PAI) ( 1 , 2 , 3