Division of Biomedical Information Analysis, Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University, Yahaba, Japan
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Faculty of Health Science, Bukkyo University, Kyoto, Japan
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immature female offspring Prenatal undernutrition results in precocious puberty in female rats ( Fig. 2 ), and UN offspring showed the lower BW until 3 weeks of age, as indicated in Fig. 2A . Figure 2B shows KNDy gene expression in the hypothalamus of
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this experiment was to study the long-term consequences of prenatal over- vs undernutrition on HPT axis function and subsequent obesity development, and to relate alterations in HPT axis function to certain whole body metabolic traits in sheep. Serum
Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
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Department of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada
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Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
Department of Paediatrics, Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada
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-blind, randomized placebo-controlled trial designed to estimate the dose-ranging effects of prenatal vitamin D supplementation (4200 IU/week, 16,800 IU/week, and 28,000 IU/week) and postpartum supplementation (28,000 IU/week among half the women receiving 28,000 IU
Willem-Alexander Children’s Hospital, Department of Pediatrics, Division of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
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link between genetic variants and undernutrition and obesity, suggesting that the same biological pathways and neuroendocrine factors could be affected, albeit in different directions. For example, 16p11.2 hemizygosity causes a penetrant form of obesity
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such as T2DM ( 30 ). We previously demonstrated that rat offspring which were exposed to undernutrition in utero and postnatal overnutrition (CG-IUGR) develop aberrant growth trajectories and, as adults, a phenotype of impaired insulin sensitivity