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Ashley N Reeb, Andrea Ziegler and Reigh-Yi Lin

tumorigenic potential of a given thyroid cancer cell line and whether they are a good choice for preclinical drug testing. In this study, we used NSG mice to evaluate the tumorigenic potential of three human FTC cell lines. This NSG mouse strain lacks mature T

Open access

Nassim Ghaffari-Tabrizi-Wizsy, Christina Angelika Passegger, Laura Nebel, Fabian Krismer, Gudrun Herzer-Schneidhofer, Gert Schwach and Roswitha Pfragner

. Therefore, this oncogene represents a key player both in MTC pathogenesis in preclinical models and as molecular target for drugs inhibiting the action of pathogenic oncoproteins. Mouse models are of fundamental importance to evaluate the efficacy of

Open access

Maria Cristina De Martino, Richard A Feelders, Claudia Pivonello, Chiara Simeoli, Fortuna Papa, Annamaria Colao, Rosario Pivonello and Leo J Hofland

preclinical models of ACCs is a mandatory step to explore whether these compounds could represent a novel treatment opportunity for the management of ACCs. Few studies have evaluated the effects of different mTOR inhibitors, sirolimus, everolimus and

Open access

Martin Zweifel, Beat Thürlimann, Salome Riniker, Patrik Weder, Roger von Moos, Olivia Pagani, Martin Bigler, Karin M Rothgiesser, Christiane Pilop, Hanne Hawle, Peter Brauchli, Coya Tapia, Wolfgang Schoenfeld, Cristiana Sessa and for the Swiss Group for Clinical Cancer Research (SAKK)

time point. Dotted lines indicate 1st and 3rd quartiles (the dotted 1st quartile line overlaps mostly with the solid mean line). Discussion In preclinical studies, CR1447 has been shown to inhibit human BC cell lines in their growth if

Open access

Giovanni Tulipano

anti-tumor effects in endocrine malignancies ( 16 ). The last section of this review explores the results of preclinical studies aimed at investigating the effects of AMPK activation and the effects of metformin on pituitary tumor cells published in the

Open access

Maximilian Bielohuby, Martin Bidlingmaier and Uwe Schwahn

– already has a high degree of standardization, it must be assumed that in the less well-controlled and standardized environment of many rodent studies the factor ‘pre-analytical variability’ might even more severely affect sample quality. Blood

Open access

David P Sonne, Asger Lund, Jens Faber, Jens J Holst, Tina Vilsbøll and Filip K Knop

-coupled receptor TGR5 (2, 3, 4) . A study by Watanabe et al . (4) carried out in mice showed that cholic acid supplementation augmented energy expenditure in brown adipose tissue, caused weight reduction and improved insulin sensitivity. The effects were

Open access

Sarah Byberg, Jesper Futtrup, Mikkel Andreassen and Jesper Krogh

Introduction In recent large cohort studies, high prolactin levels within and above the normal physiological range have been associated with increased risk of cardiovascular mortality ( 1 , 2 , 3 ). It is speculated whether this association

Open access

Aasem Saif, Shrook Mousa, Maha Assem, Nashwa Tharwat and Alaa Abdelhamid

such as dyslipidemia, hypercoagulable state, increased arterial stiffness, obesity and endothelial dysfunction ( 1 , 2 , 3 , 4 ). Current controversy centers on whether subclinical hypothyroidism (SCH) is associated with atherosclerosis. Some studies

Open access

Sweta Budyal, Swati Sachin Jadhav, Rajeev Kasaliwal, Hiren Patt, Shruti Khare, Vyankatesh Shivane, Anurag R Lila, Tushar Bandgar and Nalini S Shah

with type 2 diabetes mellitus (T2DM), obesity, osteoporosis, and polycystic ovarian syndrome (PCOS) (4, 5, 6, 7, 8) . As impaired glucose tolerance and diabetes are important metabolic manifestations of CS, several studies have attempted to examine the