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Aleksandra Gilis-Januszewska Chair and Department of Endocrinology, Jagiellonian University Medical College, Krakow, Poland
Endocrinology Department, University Hospital in Krakow, Krakow, Poland

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Łukasz Kluczyński Chair and Department of Endocrinology, Jagiellonian University Medical College, Krakow, Poland
Endocrinology Department, University Hospital in Krakow, Krakow, Poland

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Alicja Hubalewska-Dydejczyk Chair and Department of Endocrinology, Jagiellonian University Medical College, Krakow, Poland
Endocrinology Department, University Hospital in Krakow, Krakow, Poland

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more attention due to new reports of pituitary insufficiency caused by relatively mild, repetitive brain traumas. The incidence of post-traumatic hypopituitarism (PTHP) is likely underestimated. Based on the review of literature published between May

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Lára Ósk Eggertsdóttir Claessen Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland
Department of Emergency Medicine, Landspitali – The National University Hospital of Iceland, Reykjavik, Iceland

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Hafrún Kristjánsdóttir Physical Activity, Physical Education, Sport, and Health (PAPESH) Research Centre, Sports Science Department, School of Social Sciences, Reykjavik University, Reykjavik, Iceland

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María Kristín Jónsdóttir Mental Health Services, Landspitali – The National University Hospital of Iceland, Reykjavik, Iceland
Department of Psychology, School of Social Sciences, Reykjavik University, Reykjavik, Iceland

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Sigrún Helga Lund deCODE Genetics, Inc/Amgen Inc., Reykjavik, Iceland
School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland

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Ingunn Unnsteinsdóttir Kristensen Department of Psychology, School of Social Sciences, Reykjavik University, Reykjavik, Iceland

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Helga Ágústa Sigurjónsdóttir Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland
Department of Medicine, Landspitali – The National University Hospital of Iceland, Reykjavik, Iceland

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Abdennebi B Guenane K Kemali Z & Ould Kablia S . Prevalence of hypopituitarism and quality of life in survivors of post-traumatic brain injury . Endocrinology, Diabetes and Metabolism 2020 3 e00146 . ( https://doi.org/10.1002/edm2.146 ) 33

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H A Booij Department of Neurology, Medisch Spectrum Twente, Enschede, the Netherlands

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W D C Gaykema Roessingh Rehabilitation Center, Enschede, the Netherlands

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K A J Kuijpers Roessingh Rehabilitation Center, Enschede, the Netherlands

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M J M Pouwels Department of Endocrinology, Medisch Spectrum Twente, Enschede, the Netherlands

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H M den Hertog Department of Neurology, Medisch Spectrum Twente, Enschede, the Netherlands

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J Feldt-Rasmussen U. Prevalence and predictive factors of post-traumatic hypopituitarism . Clinical Endocrinology 2007 67 193 – 201 . ( https://doi.org/10.1111/j.1365-2265.2007.02860.x ) 10.1111/j.1365-2265.2007.02860.x 17524035 31

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Rachel K Rowe Phoenix Veterans Affairs Health Care System, Phoenix, Arizona, USA
BARROW Neurological Institute at Phoenix Children’s Hospital, Phoenix, Arizona, USA
Department of Child Health, University of Arizona College of Medicine – Phoenix, Phoenix, Arizona, USA

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Benjamin M Rumney BARROW Neurological Institute at Phoenix Children’s Hospital, Phoenix, Arizona, USA
Department of Child Health, University of Arizona College of Medicine – Phoenix, Phoenix, Arizona, USA
Department of Biology and Biochemistry, University of Bath, UK

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Hazel G May BARROW Neurological Institute at Phoenix Children’s Hospital, Phoenix, Arizona, USA
Department of Child Health, University of Arizona College of Medicine – Phoenix, Phoenix, Arizona, USA
Department of Biology and Biochemistry, University of Bath, UK

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Paska Permana Phoenix Veterans Affairs Health Care System, Phoenix, Arizona, USA

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P David Adelson BARROW Neurological Institute at Phoenix Children’s Hospital, Phoenix, Arizona, USA
Department of Child Health, University of Arizona College of Medicine – Phoenix, Phoenix, Arizona, USA
School of Biological and Health Systems Engineering, Arizona State University, Tempe, Arizona, USA

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S Mitchell Harman Phoenix Veterans Affairs Health Care System, Phoenix, Arizona, USA

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Jonathan Lifshitz Phoenix Veterans Affairs Health Care System, Phoenix, Arizona, USA
BARROW Neurological Institute at Phoenix Children’s Hospital, Phoenix, Arizona, USA
Department of Child Health, University of Arizona College of Medicine – Phoenix, Phoenix, Arizona, USA

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Theresa C Thomas Phoenix Veterans Affairs Health Care System, Phoenix, Arizona, USA
BARROW Neurological Institute at Phoenix Children’s Hospital, Phoenix, Arizona, USA
Department of Child Health, University of Arizona College of Medicine – Phoenix, Phoenix, Arizona, USA

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injury severity spectrum ( 15 ). Injury-induced endocrine dysfunction can be concomitant with and potentially augment clinical symptoms commonly associated with postconcussive syndrome and post-traumatic stress disorder (PTSD) ( 22 , 29 ). While the

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Jose M Garcia GRECC VA Puget Sound HCS/University of Washington, Seattle, Washington, USA

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Beverly M K Biller Massachusetts General Hospital, Neuroendocrine Unit, Boston, Massachusetts, USA

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Márta Korbonits Barts and the London School of Medicine, Queen Mary University of London, Endocrinology, London, UK

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Vera Popovic University of Belgrade, Medical Faculty, Belgrade, Serbia

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Anton Luger Division of Endocrinology and Metabolism, Medical University, General Hospital, Vienna, Austria

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Christian J Strasburger Charité-Universitätsmedizin, Clinical Endocrinology CCM, Berlin, Germany

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Philippe Chanson Assistance Publique-Hôpitaux de Paris, Hôpital de Bicêtre, Service d’Endocrinologie et des Maladies de la Reproduction, Centre de Référence des Maladies Rares de l’Hypophyse, and Université Paris-Saclay, Univ. Paris-Sud, Inserm, Signalisation Hormonale, Physiopathologie Endocrinienne et Métabolique, Le Kremlin-Bicêtre, France

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Ronald Swerdloff The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, California, USA

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Christina Wang The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, California, USA

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Rosa Rosanna Fleming Strongbridge Biopharma, Trevose, Pennsylvania, USA

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Fredric Cohen Strongbridge Biopharma, Trevose, Pennsylvania, USA

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Nicola Ammer Aeterna Zentaris GmbH, Frankfurt, Hessen, Germany

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Gilbert Mueller Aeterna Zentaris GmbH, Frankfurt, Hessen, Germany

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Nicky Kelepouris Novo Nordisk Inc., Plainsboro, New Jersey, USA

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Frank Strobl Novo Nordisk Inc., Plainsboro, New Jersey, USA

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Vlady Ostrow Novo Nordisk Inc., Plainsboro, New Jersey, USA

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Kevin C J Yuen University of Arizona College of Medicine and Creighton School of Medicine, Barrow Pituitary Center, Barrow Neurological Institute, Phoenix, Arizona, USA

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). Findings from recent studies suggest that hypopituitarism is associated with excess mortality ( 3 , 4 , 5 , 6 , 7 ), in part due to AGHD ( 8 , 9 ). In addition, if untreated, AGHD can increase the risk of future bone fractures, obesity, diabetes

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Luca Persani Division of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy
Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy

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Biagio Cangiano Division of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy
Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy

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Marco Bonomi Division of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy
Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy

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hypocortisolism and metabolic syndrome; late adrenarche and delayed rise of testosterone in males, dissociated from testicular growth ending in post-pubertal macrorchidism   PUO1F1 173110 AR, AD Variable age of onset, associated with GH and PRL

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Charlotte Höybye Patient Area Endocrinology and Nephrology, Infection and Inflammation Theme, Karolinska University Hospital, Stockholm, Sweden
Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden

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Laia Faseh Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden

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Christos Himonakos Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden
Department of Medicine, Karlstad Hospital, Karlstad, Sweden

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Tomasz Pielak NUTOPI Sp. z o. o., Poznan, Poland

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Jesper Eugen-Olsen Clinical Research Centre, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark

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craniopharyngeoma and 23 for other diseases in the area (meningioma ( N  = 7), idiopathic hypopituitarism ( N  = 6), hypophysitis ( N  = 3), empty sella ( N  = 3), opticus glioma ( N  = 2), Ratkes cyst ( N  = 1), traumatic brain injury ( N  = 1)). The patients had

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Dirk Weismann Department of Internal Medicine I, Intensivcare Unit, University Hospital of Würzburg, Würzburg, Germany

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Andreas Schneider Department of Internal Medicine I, Intensivcare Unit, University Hospital of Würzburg, Würzburg, Germany

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Charlotte Höybye Department of Endocrinology, Metabolism and Diabetology, Karolinska University Hospital, Stockholm, Sweden
Department of Molecular Surgery and Medicine, Karolinska Institute, Stockholm, Sweden

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that out of 139 patients with intermediate-to-profound HN consecutively treated in a tertiary endocrine center, 28 patients (mean age 68 years) had hypopituitarism ( 33 ). In 25 of the 28 patients, hypopituitarism was not recognized before work-up for

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Charlotte Höybye Department of Endocrinology and Department of Molecular Medicine and Surgery, Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden

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Beverly M K Biller Neuroendocrine Unit, Massachusetts General Hospital, Massachusetts General Hospital, Boston, Massachusetts, USA

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Jean-Marc Ferran Qualiance ApS, Copenhagen, Denmark

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Murray B Gordon Allegheny Neuroendocrinology Center, Division of Endocrinology, Allegheny General Hospital, Pittsburgh, Pennsylvania, USA

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Nicky Kelepouris US Medical Affairs-Rare Endocrine Disorders, Novo Nordisk, Inc, Plainsboro, New Jersey, USA

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Navid Nedjatian Global Medical Affairs – Rare Endocrine Disorders, Novo Nordisk Health Care AG, Zurich, Switzerland

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Anne H Olsen Epidemiology, Novo Nordisk A/S, Soborg, Denmark

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Matthias M Weber Unit of Endocrinology, 1, Medical Department, University Hospital, Universitätsmedizin Mainz, der Johannes Gutenberg-Universität, Mainz, Germany

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treatment 479 (67.7)  Unknown 76 (10.7)  Post-procedural hypopituitarism 70 (9.9)  Craniopharyngioma or its treatment 27 (3.8)  Traumatic brain injury 15 (2.1)  Congenital 14 (2.0)  Sheehan syndrome 12 (1

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Kevin C J Yuen Departments of Neuroendocrinology and Neurosurgery, Barrow Neurological Institute, University of Arizona College of Medicine and Creighton School of Medicine, Phoenix, Arizona, United States

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Gudmundur Johannsson Department of Endocrinology, Sahlgrenska University Hospital and Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Ken K Y Ho The Garvan Institute of Medical Research and the Faculty of Medicine, University of New South Wales, Sydney, Australia

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Bradley S Miller Pediatric Endocrinology, University of Minnesota Medical School, M Health Fairview Masonic Children’s Hospital, Minneapolis, Minnesota, United States

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Ignacio Bergada Centro de Investigaciones Endocrinológicas "Dr César Bergadá" (CEDIE), CONICET-FEI-División de Endocrinología, Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina

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Alan D Rogol Pediatric Diabetes and Endocrinology, University of Virginia, Charlottesville, Virginia, United States

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hypophysitis, and meningoencephalitis ( 28 , 29 ). In the last decade, non-tumoral causes of hypopituitarism associated with GHD (e.g. traumatic brain injury, stroke, and subarachnoid hemorrhage) have also been increasingly recognized ( 30 , 31 , 32 , 33

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