Henri Honka
Henri Honka
Turku PET Centre, University of Turku, Turku, Finland
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Jukka Koffert
Jukka Koffert
Turku PET Centre, University of Turku, Turku, Finland
Department of Gastroenterology, Turku University Hospital, Turku, Finland
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Department of Gastroenterology, Turku University Hospital, Turku, Finland
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Saila Kauhanen
Saila Kauhanen
Division of Digestive Surgery and Urology, Turku University Hospital, Turku, Finland
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Nobuyuki Kudomi
Nobuyuki Kudomi
Faculty of Medicine, Kagawa University, Kagawa, Japan
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Saija Hurme
Saija Hurme
Department of Biostatistics, University of Turku, Turku, Finland
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Andrea Mari
Andrea Mari
Institute of Neuroscience, National Research Council, Padua, Italy
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Andreas Lindqvist
Andreas Lindqvist
Department of Clinical Sciences, Lund University Diabetes Centre, Malmö, Sweden
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Nils Wierup
Nils Wierup
Department of Clinical Sciences, Lund University Diabetes Centre, Malmö, Sweden
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Riitta Parkkola
Riitta Parkkola
Department of Radiology, University of Turku and Turku University Hospital, Turku, Finland
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Leif Groop
Leif Groop
Department of Clinical Sciences, Lund University Diabetes Centre, Malmö, Sweden
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Pirjo Nuutila
Pirjo Nuutila
Turku PET Centre, University of Turku, Turku, Finland
Department of Endocrinology, Turku University Hospital, Turku, Finland
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Department of Endocrinology, Turku University Hospital, Turku, Finland
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quantitated blood flow in portal vein (PV) and hepatic artery (HA), and HBV during a mixed-meal test and GIP infusion in morbidly obese subjects with T2D and age-matched lean controls with positron emission tomography/magnetic resonance imaging (PET/MRI). The
Meena Asmar
Meena Asmar
Department of Endocrinology, Bispebjerg and Frederiksberg Hospital, University Hospital of Copenhagen, Copenhagen, Denmark
Department of Clinical Physiology and Nuclear Medicine, Bispebjerg and Frederiksberg Hospital, University Hospital of Copenhagen, Copenhagen, Denmark
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Department of Clinical Physiology and Nuclear Medicine, Bispebjerg and Frederiksberg Hospital, University Hospital of Copenhagen, Copenhagen, Denmark
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Ali Asmar
Ali Asmar
Department of Clinical Physiology and Nuclear Medicine, Bispebjerg and Frederiksberg Hospital, University Hospital of Copenhagen, Copenhagen, Denmark
Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark
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Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark
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Lene Simonsen
Lene Simonsen
Department of Clinical Physiology and Nuclear Medicine, Bispebjerg and Frederiksberg Hospital, University Hospital of Copenhagen, Copenhagen, Denmark
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Flemming Dela
Flemming Dela
Xlab, Center for Healthy Ageing, University of Copenhagen, Copenhagen, Denmark
Department of Geriatrics, Bispebjerg and Frederiksberg Hospital, University Hospital of Copenhagen, Copenhagen, Denmark
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Department of Geriatrics, Bispebjerg and Frederiksberg Hospital, University Hospital of Copenhagen, Copenhagen, Denmark
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Jens Juul Holst
Jens Juul Holst
NNF Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark
Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark
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Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark
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Jens Bülow
Jens Bülow
Department of Clinical Physiology and Nuclear Medicine, Bispebjerg and Frederiksberg Hospital, University Hospital of Copenhagen, Copenhagen, Denmark
Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark
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Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark
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Introduction The regulation of subcutaneous adipose tissue blood flow (ATBF) is crucial in lipid homeostasis ( 1 , 2 ). It has long been recognized that the ATBF is tightly coupled to adipose tissue metabolism ( 3 , 4 , 5 , 6 ). In
Paola Parra Ramírez
Paola Parra Ramírez
Endocrinology & Nutrition Department, La Paz University Hospital, Madrid, Spain
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Patricia Martín Rojas-Marcos
Patricia Martín Rojas-Marcos
Endocrinology & Nutrition Department, La Paz University Hospital, Madrid, Spain
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Miguel Paja Fano
Miguel Paja Fano
Endocrinology & Nutrition Department, Hospital Universitario de Basurto, Bilbao, Spain
Medicine Department, Basque Country University, Bilbao, Spain
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Medicine Department, Basque Country University, Bilbao, Spain
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Marga González Boillos
Marga González Boillos
Endocrinology & Nutrition Department, Hospital Universitario de Castellón, Castellón, Spain
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Eider Pascual-Corrales
Eider Pascual-Corrales
Endocrinology & Nutrition Department, Hospital Universitario Ramón y Cajal, Madrid, Spain
Instituto de Investigación Biomédica Ramón y Cajal (IRYCIS), Madrid, Spain
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Instituto de Investigación Biomédica Ramón y Cajal (IRYCIS), Madrid, Spain
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Ana García-Cano
Ana García-Cano
Biochemistry Department, Hospital Universitario Ramón y Cajal, Madrid, Spain
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Jorge Gabriel Ruiz-Sanchez
Jorge Gabriel Ruiz-Sanchez
Endocrinology & Nutrition Department, Hospital Fundación Jiménez Díaz, Madrid, Spain
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Almudena Vicente
Almudena Vicente
Endocrinology & Nutrition Department, Complejo Universitario de Toledo, Toledo, Spain
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Emilia Gómez-Hoyos
Emilia Gómez-Hoyos
Endocrinology & Nutrition Department, Hospital Clínico Universitario de Valladolid, Valladolid, Spain
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Rui Ferreira
Rui Ferreira
Endocrinology & Nutrition Department, Hospital Universitario de La Princesa, Madrid, Spain
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Iñigo García Sanz
Iñigo García Sanz
General & Digestive Surgery Department, Hospital Universitario de La Princesa, Madrid, Spain
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Mònica Recasens
Mònica Recasens
Endocrinology & Nutrition Department, Hospital Josep Trueta, Servei d’Endocrinologia, Girona, Spain
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Begoña Pla Peris
Begoña Pla Peris
Endocrinology & Nutrition Department, Hospital Universitario de Castellón, Castellón, Spain
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Rebeca Barahona San Millan
Rebeca Barahona San Millan
Endocrinology & Nutrition Department, Hospital Josep Trueta, Servei d’Endocrinologia, Girona, Spain
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María José Picón César
María José Picón César
Endocrinology & Nutrition Department, Complejo Hospitalario Málaga (Hospital Virgen de la Victoria), IBIMA Malaga, Malaga, Spain
CIBEROBN, Madrid, Spain
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CIBEROBN, Madrid, Spain
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Patricia Díaz Guardiola
Patricia Díaz Guardiola
Endocrinology & Nutrition Department, Hospital Universitario Infanta Sofía, Madrid, Spain
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Juan Jesús García González
Juan Jesús García González
Endocrinology & Nutrition Department, Hospital Universitario Virgen de la Macarena, Sevilla, Spain
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Carolina Perdomo
Carolina Perdomo
Endocrinology & Nutrition Department, Clínica Universidad de Navarra, Pamplona, Spain
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Laura Manjón
Laura Manjón
Endocrinology & Nutrition Department, Hospital Universitario Central de Asturias, Oviedo, Spain
Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain
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Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain
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Rogelio García-Centeno
Rogelio García-Centeno
Endocrinology & Nutrition Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain
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Juan Carlos Percovich
Juan Carlos Percovich
Endocrinology & Nutrition Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain
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Ángel Rebollo Román
Ángel Rebollo Román
Endocrinology & Nutrition Department, Hospital Reina Sofía, Córdoba, Spain
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Paola Gracia Gimeno
Paola Gracia Gimeno
Endocrinology & Nutrition Department, Hospital Royo Villanova, Zaragoza, Spain
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Cristina Robles Lázaro
Cristina Robles Lázaro
Endocrinology & Nutrition Department, Hospital Universitario de Salamanca, Salamanca, Spain
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Manuel Morales
Manuel Morales
Biochemistry and Molecular Genetics Department-CDB, Hospital Clinic, IDIBAPS, CIBERehd, Barcelona, Spain
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Felicia Hanzu
Felicia Hanzu
Endocrinology & Nutrition Department, Hospital Clinic, Barcelona, Spain
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Marta Araujo-Castro
Marta Araujo-Castro
Endocrinology & Nutrition Department, Hospital Universitario Ramón y Cajal, Madrid, Spain
Instituto de Investigación Biomédica Ramón y Cajal (IRYCIS), Madrid, Spain
University of Alcalá, Madrid, Spain
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Instituto de Investigación Biomédica Ramón y Cajal (IRYCIS), Madrid, Spain
University of Alcalá, Madrid, Spain
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). Patients with PA have a higher cardiometabolic risk profile, with four times increased risk for stroke and six times for nonfatal myocardial infarction, than patients with essential hypertension (EHT) matched by blood pressure (BP), sex, and age ( 2 , 3
Antonia Ertelt
Antonia Ertelt
Equine Clinic, Free University of Berlin, Berlin, Germany
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Ann-Kristin Barton
Ann-Kristin Barton
Equine Clinic, Free University of Berlin, Berlin, Germany
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Robert R Schmitz
Robert R Schmitz
Equine Clinic, Free University of Berlin, Berlin, Germany
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Heidrun Gehlen
Heidrun Gehlen
Equine Clinic, Free University of Berlin, Berlin, Germany
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areas of terminal circulation include an artery, which is usually situated in the axis of the lobule, while a paired vein collects blood on the surface. In contrast to former reports, the fat tissue is a highly perfused tissue (15, 16) . Based on the
Jordyn Silverstein
Jordyn Silverstein
Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA
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Wesley Kidder
Wesley Kidder
Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA
Division of Hematology and Oncology, Department of Medicine, University of California, San Francisco, California, USA
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Division of Hematology and Oncology, Department of Medicine, University of California, San Francisco, California, USA
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Susan Fisher
Susan Fisher
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, California, USA
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Thomas A Hope
Thomas A Hope
Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA
Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA
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Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA
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Samantha Maisel
Samantha Maisel
Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA
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Dianna Ng
Dianna Ng
Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA
Department of Pathology, University of California, San Francisco, California, USA
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Department of Pathology, University of California, San Francisco, California, USA
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Jessica Van Ziffle
Jessica Van Ziffle
Department of Pathology, University of California, San Francisco, California, USA
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Chloe E Atreya
Chloe E Atreya
Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA
Division of Hematology and Oncology, Department of Medicine, University of California, San Francisco, California, USA
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Division of Hematology and Oncology, Department of Medicine, University of California, San Francisco, California, USA
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Katherine Van Loon
Katherine Van Loon
Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA
Division of Hematology and Oncology, Department of Medicine, University of California, San Francisco, California, USA
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Division of Hematology and Oncology, Department of Medicine, University of California, San Francisco, California, USA
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numerous hypodense metastases within the liver, with associated compression of the right portal vein, distal sigmoid colon thickening with adenopathy ( Fig. 1 ). A colonoscopy identified a partially circumferential mass in the sigmoid colon, which was
Rachel K Rowe
Rachel K Rowe
Phoenix Veterans Affairs Health Care System, Phoenix, Arizona, USA
BARROW Neurological Institute at Phoenix Children’s Hospital, Phoenix, Arizona, USA
Department of Child Health, University of Arizona College of Medicine – Phoenix, Phoenix, Arizona, USA
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BARROW Neurological Institute at Phoenix Children’s Hospital, Phoenix, Arizona, USA
Department of Child Health, University of Arizona College of Medicine – Phoenix, Phoenix, Arizona, USA
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Benjamin M Rumney
Benjamin M Rumney
BARROW Neurological Institute at Phoenix Children’s Hospital, Phoenix, Arizona, USA
Department of Child Health, University of Arizona College of Medicine – Phoenix, Phoenix, Arizona, USA
Department of Biology and Biochemistry, University of Bath, UK
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Department of Child Health, University of Arizona College of Medicine – Phoenix, Phoenix, Arizona, USA
Department of Biology and Biochemistry, University of Bath, UK
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Hazel G May
Hazel G May
BARROW Neurological Institute at Phoenix Children’s Hospital, Phoenix, Arizona, USA
Department of Child Health, University of Arizona College of Medicine – Phoenix, Phoenix, Arizona, USA
Department of Biology and Biochemistry, University of Bath, UK
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Department of Child Health, University of Arizona College of Medicine – Phoenix, Phoenix, Arizona, USA
Department of Biology and Biochemistry, University of Bath, UK
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Paska Permana
Paska Permana
Phoenix Veterans Affairs Health Care System, Phoenix, Arizona, USA
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P David Adelson
P David Adelson
BARROW Neurological Institute at Phoenix Children’s Hospital, Phoenix, Arizona, USA
Department of Child Health, University of Arizona College of Medicine – Phoenix, Phoenix, Arizona, USA
School of Biological and Health Systems Engineering, Arizona State University, Tempe, Arizona, USA
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Department of Child Health, University of Arizona College of Medicine – Phoenix, Phoenix, Arizona, USA
School of Biological and Health Systems Engineering, Arizona State University, Tempe, Arizona, USA
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S Mitchell Harman
S Mitchell Harman
Phoenix Veterans Affairs Health Care System, Phoenix, Arizona, USA
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Jonathan Lifshitz
Jonathan Lifshitz
Phoenix Veterans Affairs Health Care System, Phoenix, Arizona, USA
BARROW Neurological Institute at Phoenix Children’s Hospital, Phoenix, Arizona, USA
Department of Child Health, University of Arizona College of Medicine – Phoenix, Phoenix, Arizona, USA
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BARROW Neurological Institute at Phoenix Children’s Hospital, Phoenix, Arizona, USA
Department of Child Health, University of Arizona College of Medicine – Phoenix, Phoenix, Arizona, USA
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Theresa C Thomas
Theresa C Thomas
Phoenix Veterans Affairs Health Care System, Phoenix, Arizona, USA
BARROW Neurological Institute at Phoenix Children’s Hospital, Phoenix, Arizona, USA
Department of Child Health, University of Arizona College of Medicine – Phoenix, Phoenix, Arizona, USA
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BARROW Neurological Institute at Phoenix Children’s Hospital, Phoenix, Arizona, USA
Department of Child Health, University of Arizona College of Medicine – Phoenix, Phoenix, Arizona, USA
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their cage and anesthetized for 5min with isoflurane. Immediately following anesthesia, rats were secured in a stereotaxic frame and blood collection (250µL) through a tail vein occurred. At 54 and 56 DPI, rats underwent restraint stress and blood
Antonina Khoruzhenko
Antonina Khoruzhenko
Institute of Interdisciplinary Research (IRIBHM), Université libre de Bruxelles, Brussels, Belgium
Institute of Molecular Biology and Genetics, NAS of Ukraine, Kiev, Ukraine
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Institute of Molecular Biology and Genetics, NAS of Ukraine, Kiev, Ukraine
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Françoise Miot
Françoise Miot
Institute of Interdisciplinary Research (IRIBHM), Université libre de Bruxelles, Brussels, Belgium
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Claude Massart
Claude Massart
Institute of Interdisciplinary Research (IRIBHM), Université libre de Bruxelles, Brussels, Belgium
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Jacqueline Van Sande
Jacqueline Van Sande
Institute of Interdisciplinary Research (IRIBHM), Université libre de Bruxelles, Brussels, Belgium
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Jacques Emile Dumont
Jacques Emile Dumont
Institute of Interdisciplinary Research (IRIBHM), Université libre de Bruxelles, Brussels, Belgium
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Renaud Beauwens
Renaud Beauwens
Laboratory of Physiology and Pharmacology, Université libre de Bruxelles, Brussels, Belgium
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Alain Boom
Alain Boom
Laboratoire d’Histologie, de Neuroanatomie et de Neuropathologie, Université libre de Bruxelles, Brussels, Belgium
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thyroid follicles transplanted via the portal vein into the liver of rats retained their histoarchitecture and functional activity up to 18 months and caused significant histochemical alterations of liver acini ( 25 ). Thus, the development of cell
Richard P Steeds
Richard P Steeds
Department of Cardiology, University Hospitals Birmingham (Queen Elizabeth), NHS Hospitals Foundation Trust, Birmingham, UK
Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK
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Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK
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Vandana Sagar
Vandana Sagar
Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK
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Shishir Shetty
Shishir Shetty
Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK
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Tessa Oelofse
Tessa Oelofse
Departments of Anaesthesia and Intensive Care, University Hospitals Birmingham (Queen Elizabeth), NHS Hospitals Foundation Trust, Birmingham, UK
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Harjot Singh
Harjot Singh
Departments of Anaesthesia and Intensive Care, University Hospitals Birmingham (Queen Elizabeth), NHS Hospitals Foundation Trust, Birmingham, UK
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Raheel Ahmad
Raheel Ahmad
Department of Cardiology, University Hospitals Birmingham (Queen Elizabeth), NHS Hospitals Foundation Trust, Birmingham, UK
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Elizabeth Bradley
Elizabeth Bradley
Therapy Services (Dietetics), University Hospitals Birmingham (Queen Elizabeth), NHS Hospitals Foundation Trust, Birmingham, UK
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Rachel Moore
Rachel Moore
Departments of Anaesthesia and Intensive Care, University Hospitals Birmingham (Queen Elizabeth), NHS Hospitals Foundation Trust, Birmingham, UK
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Suzanne Vickrage
Suzanne Vickrage
Birmingham Neuroendocrine Tumour Centre, University Hospitals Birmingham (Queen Elizabeth), NHS Hospitals Foundation Trust, Birmingham, UK
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Stacey Smith
Stacey Smith
Birmingham Neuroendocrine Tumour Centre, University Hospitals Birmingham (Queen Elizabeth), NHS Hospitals Foundation Trust, Birmingham, UK
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Ivan Yim
Ivan Yim
Department of Cardiothoracic Surgery, University Hospitals Birmingham (Queen Elizabeth), NHS Hospitals Foundation Trust, Birmingham, UK
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Yasir S Elhassan
Yasir S Elhassan
Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK
Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK
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Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK
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Hema Venkataraman
Hema Venkataraman
Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK
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John Ayuk
John Ayuk
Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK
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Stephen Rooney
Stephen Rooney
Department of Cardiothoracic Surgery, University Hospitals Birmingham (Queen Elizabeth), NHS Hospitals Foundation Trust, Birmingham, UK
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Tahir Shah
Tahir Shah
Birmingham Neuroendocrine Tumour Centre, University Hospitals Birmingham (Queen Elizabeth), NHS Hospitals Foundation Trust, Birmingham, UK
Department of Hepatology and Liver Transplantation, University Hospitals Birmingham (Queen Elizabeth), NHS Hospitals Foundation Trust, Birmingham, UK
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Department of Hepatology and Liver Transplantation, University Hospitals Birmingham (Queen Elizabeth), NHS Hospitals Foundation Trust, Birmingham, UK
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portal circulation into the liver, where they are degraded. When GI NETs have metastasised to the liver, retro-peritoneal lymph nodes or ovaries, the hormones released by-pass degradation in the liver and gain access to the systemic circulation, causing
