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  • poly (ADP-ribose) polymerase 1 (PARP1) x
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Fernando Aprile-Garcia Instituto de Investigación en Biomedicina de Buenos Aires – CONICET, Departamento de Fisiología, Partner Institute of the Max Planck Society, Buenos Aires, Argentina
Instituto de Investigación en Biomedicina de Buenos Aires – CONICET, Departamento de Fisiología, Partner Institute of the Max Planck Society, Buenos Aires, Argentina

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María Antunica-Noguerol Instituto de Investigación en Biomedicina de Buenos Aires – CONICET, Departamento de Fisiología, Partner Institute of the Max Planck Society, Buenos Aires, Argentina
Instituto de Investigación en Biomedicina de Buenos Aires – CONICET, Departamento de Fisiología, Partner Institute of the Max Planck Society, Buenos Aires, Argentina

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Maia Ludmila Budziñski Instituto de Investigación en Biomedicina de Buenos Aires – CONICET, Departamento de Fisiología, Partner Institute of the Max Planck Society, Buenos Aires, Argentina

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Ana C Liberman Instituto de Investigación en Biomedicina de Buenos Aires – CONICET, Departamento de Fisiología, Partner Institute of the Max Planck Society, Buenos Aires, Argentina

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Eduardo Arzt Instituto de Investigación en Biomedicina de Buenos Aires – CONICET, Departamento de Fisiología, Partner Institute of the Max Planck Society, Buenos Aires, Argentina
Instituto de Investigación en Biomedicina de Buenos Aires – CONICET, Departamento de Fisiología, Partner Institute of the Max Planck Society, Buenos Aires, Argentina

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matter, one specific molecule that has caught the attention of researchers in the last few years is poly (ADP-ribose) polymerase 1 (PARP1). This long-known protein is starting to reveal new and exciting functions, some of them related with endocrine

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-13-0079
Volume/Issue:
Volume 3: Issue 1
Open access
Chanyang Kim Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul, Korea

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Seungjoon Park Department of Pharmacology and Medical Research Center for Bioreaction to ROS and Biomedical Science Institute, School of Medicine, Kyung Hee University, Seoul, Korea

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. Dulbecco’s modified Eagle’s medium (DMEM)/F12 was from Gibco/Invitrogen. Primary antibodies to caspase-3, cleaved poly(ADP-ribose) polymerase (PARP), Bcl-2, Bax, cytochrome c, PDK1, Akt and were obtained from Cell Signaling Technology. Bax was purchased

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-17-0350
Volume/Issue:
Volume 7: Issue 3
Open access
Michael Ulm University of Tennessee Health Science Center, Memphis, Tennessee, USA
West Cancer Center, Memphis, Tennessee, USA

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Arvind V Ramesh White Station High School, Memphis, Tennessee, USA

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Keely M McNamara Tohoku University, Miyagi, Japan

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Suriyan Ponnusamy University of Tennessee Health Science Center, Memphis, Tennessee, USA

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Hironobu Sasano Tohoku University, Miyagi, Japan

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Ramesh Narayanan University of Tennessee Health Science Center, Memphis, Tennessee, USA
West Cancer Center, Memphis, Tennessee, USA

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endocrine therapy. Similar to the CDK4/6 inhibitors, preclinical evidence suggested that these agents may be effective in other breast cancer subtypes, such as early-stage TNBC ( 92 ). Poly (ADP-ribose) polymerase (PARP) inhibitors PARP binds and

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-18-0425
Volume/Issue:
Volume 8: Issue 2
Open access
Kaili Yang Department of Medical Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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Jiarui Li Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, China

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Yuejuan Cheng Department of Medical Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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Chunmei Bai Department of Medical Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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therapy. We further analyzed the mechanisms of targeted drugs evaluated in ongoing trials ( Fig. 4 ). Multitarget TKIs were most frequently investigated (15 (35.7%)), followed by mTOR inhibitors (8 (19%)), poly ADP-ribose polymerase (PARP

Article Type:
Research Article
Collections:
Hormones and Cancer
DOI:
https://doi.org/10.1530/EC-22-0441
Volume/Issue:
Volume 12: Issue 4
Open access