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Panisa Hantrakun Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

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Rattanaporn Sekararithi Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

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Thidarat Jaiwongkam Cardiac Electrophysiology Research and Training Center (CERT), Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

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Sirinart Kumfu Cardiac Electrophysiology Research and Training Center (CERT), Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

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Chatree Chai-adisaksopha Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

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Nipon Chattipakorn Cardiac Electrophysiology Research and Training Center (CERT), Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

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Theera Tongsong Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

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Phudit Jatavan Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

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Highlight Metformin significantly reduces fetal weight in women with GDM, theoretically preventing macrosomia. Metformin does not improve oxidative stress and platelet dysfunction in women with GDM. Introduction

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Xue-Jiao Yang School of Public Health, Medical College of Soochow University, Suzhou, China

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Le-Yang Zhang Medical College of Soochow University, Suzhou, China

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Qing-Hua Ma The 3rd People’s Hospital of Xiangcheng District, Suzhou, China

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Hong-Peng Sun School of Public Health, Medical College of Soochow University, Suzhou, China

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Yong Xu School of Public Health, Medical College of Soochow University, Suzhou, China

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Xing Chen Department of Children Health Care, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, China

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Chen-Wei Pan School of Public Health, Medical College of Soochow University, Suzhou, China

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. Platelet parameters may be promising biomarkers for predicting early signs of metabolic abnormalities. The pathophysiology of MetS includes inflammation, insulin resistance, oxidative stress and endothelial dysfunction and triggers platelet hyperactivity

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Zeeshan Javed Department of Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull, UK
Department of Endocrinology and Diabetes, Pakistan Kidney and Liver Institute and Research Centre, Knowledge City, Lahore, Pakistan

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Maria Papageorgiou Department of Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull, UK
Division of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland

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Leigh A Madden School of Life Sciences, University of Hull, Hull, UK

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Alan S Rigby Hull York Medical School, University of Hull, Hull, UK

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Eric S Kilpatrick Department of Pathology, Sidra Medical and Research Center, Doha, Qatar

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Stephen L Atkin Royal College of Surgeons in Ireland, Al Sayh, Bahrain

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Thozhukat Sathyapalan Department of Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull, UK

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://doi.org/10.1007/s00441-008-0710-9 ) 15 Pepene CE . Soluble platelet/endothelial cell adhesion molecule (sPECAM)-1 is increased in polycystic ovary syndrome and related to endothelial dysfunction . Gynecological Endocrinology 2012 28 370 – 374

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Wang Chengji College of Physical Education, Chaohu University, Anhui Province, China

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Fan Xianjin College of Physical Education, Chaohu University, Anhui Province, China

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and stored in Weibel-Palade bodies, involved in coagulation, hemostasis, platelet aggregation and adhesion. When the vascular endothelial cells are normal, the plasma vWF content is small, and when the vascular endothelial cells are damaged, the

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Clara Lundetoft Clausen Center of Research & Disruption of Infectious Diseases, Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre, Denmark

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Åse Krogh Rasmussen Department of Medical Endocrinology and Metabolism, Copenhagen University Hospital, Copenhagen, Denmark

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Trine Holm Johannsen Department of Growth and Reproduction, Copenhagen University Hospital, Copenhagen, Denmark

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Linda Maria Hilsted Department of Clinical Biochemistry, Copenhagen University Hospital, Copenhagen, Denmark

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Niels Erik Skakkebæk Department of Growth and Reproduction, Copenhagen University Hospital, Copenhagen, Denmark

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Pal Bela Szecsi Department of Clinical Biochemistry, Holbæk Hospital, Holbæk, Denmark

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Lise Pedersen Department of Clinical Biochemistry, Holbæk Hospital, Holbæk, Denmark

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Thomas Benfield Center of Research & Disruption of Infectious Diseases, Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Anders Juul Department of Growth and Reproduction, Copenhagen University Hospital, Copenhagen, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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alterations in the hormonal secretion from the thyroid gland ( 2 , 3 , 4 ). Studies have shown varying degrees of thyroid dysfunction among patients with COVID-19 infection with 5–20% being hyperthyroid and up to 5% being hypothyroid ( 5 , 6 , 7 , 8 , 9

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Daisuke Watanabe Department of Endocrinology and Hypertension, Tokyo Women’s Medical University, Shinjuku-ku, Tokyo, Japan

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Satoshi Morimoto Department of Endocrinology and Hypertension, Tokyo Women’s Medical University, Shinjuku-ku, Tokyo, Japan

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Noriko Morishima Department of Endocrinology and Hypertension, Tokyo Women’s Medical University, Shinjuku-ku, Tokyo, Japan

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Atsuhiro Ichihara Department of Endocrinology and Hypertension, Tokyo Women’s Medical University, Shinjuku-ku, Tokyo, Japan

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necessary for survival, excess aldosterone is associated with inflammation, fibrosis, vascular damage, and end-organ failure and induces vascular dysfunction and remodeling ( 2 ). The incidence of cardiovascular morbidity is higher among patients with PA

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Chenjia Tang Department of Endocrinology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China

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Yanting Dong Department of Endocrinology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China
Department of Endocrinology, Suichang County Hospital of Traditional Chinese Medicine, Lishui, China

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Lusi Lu Department of Endocrinology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China

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Nan Zhang Department of Endocrinology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China

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uptake scans were performed before the patients received treatment. White blood cell (WBC) count, neutrophil (Neu) count, mean platelet volume (MPV), platelets (PLT), and lymphocytes were measured using an automatic blood analysis line (CAL-8000; Mindray

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Tao Gao Department of General Practice, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China

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Rui Liu Department of Oncology. The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China

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Chunli Li Institute of Life Sciences, Chongqing Medical University, Chongqing, China

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Xinglin Chu Department of General Practice, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China

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Qiao Guo Department of General Practice, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China

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Dazhi Ke Department of General Practice, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China

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). Fetuin-B plays an important role in regulating lipid metabolism and can result in lipid abnormalities that increase the risk of hypertension, cardiovascular disease, and endothelial dysfunction. Fetuin-B can cause macrophages to accumulate lipids in a

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Malin Nylander Department of Obstetrics and Gynecology, Herlev Gentofte Hospital, Herlev, Denmark
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Signe Frøssing Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Department of Internal Medicine, Endocrine Unit, Herlev Gentofte Hospital, Herlev, Denmark

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Caroline Kistorp Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Department of Internal Medicine, Endocrine Unit, Herlev Gentofte Hospital, Herlev, Denmark

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Jens Faber Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Department of Internal Medicine, Endocrine Unit, Herlev Gentofte Hospital, Herlev, Denmark

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Sven O Skouby Department of Obstetrics and Gynecology, Herlev Gentofte Hospital, Herlev, Denmark
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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polycystic ovaries, where a minimum of two should be fulfilled and other etiologies excluded ( 2 ). The Rotterdam criteria encompass an ovarian dysfunction, but it is evident that PCOS also has a metabolic component, covering abdominal obesity, hypertension

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Wang-shu Liu Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China

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Ling-yan Hua Department of Ophthalmology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China

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Su-xiang Zhu Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China

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Feng Xu Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China

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Xue-qin Wang Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China

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Chun-feng Lu Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China

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Jian-bin Su Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China

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Feng Qi Emergency Intensive Care Unit, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China

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innervated by sympathetic fibers ( 19 ). A review published in 2019 compared different tests for the detection of sudomotor dysfunction and found that ESC results achieved by the EZSCAN test might be more sensitive, less expensive, and easier to operate than

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