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Highlight Metformin significantly reduces fetal weight in women with GDM, theoretically preventing macrosomia. Metformin does not improve oxidative stress and platelet dysfunction in women with GDM. Introduction
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. Platelet parameters may be promising biomarkers for predicting early signs of metabolic abnormalities. The pathophysiology of MetS includes inflammation, insulin resistance, oxidative stress and endothelial dysfunction and triggers platelet hyperactivity
Department of Endocrinology and Diabetes, Pakistan Kidney and Liver Institute and Research Centre, Knowledge City, Lahore, Pakistan
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Division of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland
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://doi.org/10.1007/s00441-008-0710-9 ) 15 Pepene CE . Soluble platelet/endothelial cell adhesion molecule (sPECAM)-1 is increased in polycystic ovary syndrome and related to endothelial dysfunction . Gynecological Endocrinology 2012 28 370 – 374
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and stored in Weibel-Palade bodies, involved in coagulation, hemostasis, platelet aggregation and adhesion. When the vascular endothelial cells are normal, the plasma vWF content is small, and when the vascular endothelial cells are damaged, the
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Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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alterations in the hormonal secretion from the thyroid gland ( 2 , 3 , 4 ). Studies have shown varying degrees of thyroid dysfunction among patients with COVID-19 infection with 5–20% being hyperthyroid and up to 5% being hypothyroid ( 5 , 6 , 7 , 8 , 9
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necessary for survival, excess aldosterone is associated with inflammation, fibrosis, vascular damage, and end-organ failure and induces vascular dysfunction and remodeling ( 2 ). The incidence of cardiovascular morbidity is higher among patients with PA
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Department of Endocrinology, Suichang County Hospital of Traditional Chinese Medicine, Lishui, China
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uptake scans were performed before the patients received treatment. White blood cell (WBC) count, neutrophil (Neu) count, mean platelet volume (MPV), platelets (PLT), and lymphocytes were measured using an automatic blood analysis line (CAL-8000; Mindray
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). Fetuin-B plays an important role in regulating lipid metabolism and can result in lipid abnormalities that increase the risk of hypertension, cardiovascular disease, and endothelial dysfunction. Fetuin-B can cause macrophages to accumulate lipids in a
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Department of Internal Medicine, Endocrine Unit, Herlev Gentofte Hospital, Herlev, Denmark
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Department of Internal Medicine, Endocrine Unit, Herlev Gentofte Hospital, Herlev, Denmark
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Department of Internal Medicine, Endocrine Unit, Herlev Gentofte Hospital, Herlev, Denmark
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Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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polycystic ovaries, where a minimum of two should be fulfilled and other etiologies excluded ( 2 ). The Rotterdam criteria encompass an ovarian dysfunction, but it is evident that PCOS also has a metabolic component, covering abdominal obesity, hypertension
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innervated by sympathetic fibers ( 19 ). A review published in 2019 compared different tests for the detection of sudomotor dysfunction and found that ESC results achieved by the EZSCAN test might be more sensitive, less expensive, and easier to operate than