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Annieke C G van Baar, Andrei Prodan, Camilla D Wahlgren, Steen S Poulsen, Filip K Knop, Albert K Groen, Jacques J Bergman, Max Nieuwdorp and Evgeni Levin

is not clear whether and how the densities of L, K and D cells, respectively, are involved in the regulation of MetS features. In this cross-sectional study, we aimed to identify plasma metabolites that associate with duodenal L cell, K cell and D

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L Ghataore, I Chakraborti, S J Aylwin, K-M Schulte, D Dworakowska, P Coskeran and N F Taylor

summarised in Fig. 1 . On limited data, these changes appear to be essentially complete at plasma concentrations of mitotane that are much lower than the therapeutic range. The urinary 6-hydroxylated metabolites are confirmed as being present at relatively

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Nicolai J Wewer Albrechtsen, Monika J Bak, Bolette Hartmann, Louise Wulff Christensen, Rune E Kuhre, Carolyn F Deacon and Jens J Holst

peptidase 4 (DPP4), the enzyme responsible for the initial rapid degradation of the intact (7–36NH 2 ) GLP-1 to its metabolite (9–36NH 2 ) (2, 3) . The closely related peptide, glucagon, is not a substrate for DPP4 under physiological circumstances (4

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Li Jing and Wang Chengji

mellitus ( 10 , 11 , 12 ). Moreover, recent metabolomic-based studies have described the first metabolic signatures of exercise in human plasma ( 13 , 14 , 15 ). For example, Lewis et al . ( 13 ) described the metabolic changes in tricarboxylic acid

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Mohammed S Albreiki, Benita Middleton and Shelagh M Hampton

-IR (A) and HOMA-PP (B) (mean ±  s.e.m. ) during BL and DL ▬ sessions ( n  = 17). Discussion Few studies have investigated the influence of light at night on plasma hormones and metabolites in healthy humans as a majority of the studies

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Martin Zweifel, Beat Thürlimann, Salome Riniker, Patrik Weder, Roger von Moos, Olivia Pagani, Martin Bigler, Karin M Rothgiesser, Christiane Pilop, Hanne Hawle, Peter Brauchli, Coya Tapia, Wolfgang Schoenfeld, Cristiana Sessa and for the Swiss Group for Clinical Cancer Research (SAKK)

included as an additional secondary endpoint later on. Pharmacokinetics (PK) and pharmacodynamics (PD) Plasma and serum 4-OHT, 4-OHA (for PK) and oestradiol (for PD) concentrations were measured at baseline, after single dose administration at 1, 2

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Chao Xu, Xiang-Fei Li, Hong-Yan Tian, Hua-Juan Shi, Ding-Dong Zhang, Kenneth Prudence Abasubong and Wen-Bin Liu

. Analysis of plasma and liver metabolites and enzymes Plasma insulin level was analyzed by the radioimmunoassay method ( 33 ). Insulin concentration was expressed in ng/mL. This method was previously validated in common carp ( Cyprinus carpio L.) by Hertz

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Peter Ergang, Anna Mikulecká, Martin Vodicˇka, Karla Vagnerová, Ivan Mikšík and Jirˇí Pácha

-induced suppression of inflammation ( 3 ). Acute stress increases transiently plasma glucocorticoids, whereas chronic stress is associated with a chronic elevation of circulating glucocorticoids ( 4 ). The response of the target cells to glucocorticoids does not

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Anette Lundqvist, Herbert Sandström and Torbjörn Bäckström

and its metabolite allopregnanolone, in non-pregnant women are produced in the adrenal and the ovary, and in the brain of the mother ( 8 , 9 ). During pregnancy allopregnanolone is also synthesized in the placenta ( 10 ) and in the fetus, causing

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Magnolia Ariza-Nieto, Joshua B Alley, Sanjay Samy, Laura Fitzgerald, Francoise Vermeylen, Michael L Shuler and José O Alemán

Introduction Adiponectin (Adp) is a peptide hormone expressed primarily in adipose tissue ( 1 ), which shows paradoxical decreased secretion as adiposity increases ( 2 ). Plasma adiponectin levels in human are not always necessarily