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M Axelstad Technical University of Denmark, National Food Institute, Kongens Lyngby, Denmark

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U Hass Technical University of Denmark, National Food Institute, Kongens Lyngby, Denmark

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M Scholze Brunel University, Uxbridge, UK

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S Christiansen Technical University of Denmark, National Food Institute, Kongens Lyngby, Denmark

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A Kortenkamp Brunel University, Uxbridge, UK

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J Boberg Technical University of Denmark, National Food Institute, Kongens Lyngby, Denmark

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were the two phthalates, di-n-butyl phthalate (DBP), di-(2-ethylhexyl) phthalate (DEHP), the five pesticides vinclozolin, prochloraz, procymidone, linuron, epoxiconazole and the pesticide metabolite dichlorodiphenyl-dichloroethylene (p,p′-DDE). The four

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Rosalie Cabry Amiens University, Amiens, Haut-de-France, France

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Philippe Merviel Brest University, Brest, Bretagne, France

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Aicha Madkour Mohammed V University of Rabat, Reproductive Medicine, Rabat, Morocco

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Elodie Lefranc Amiens University, Amiens, Haut-de-France, France

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Florence Scheffler Amiens University, Amiens, Haut-de-France, France

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Rachel Desailloud Amiens University, Amiens, Haut-de-France, France

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Véronique Bach Amiens University, Amiens, Haut-de-France, France

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Moncef Benkhalifa Amiens University, Amiens, Haut-de-France, France

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might be related to one or more environmental factors, such as exposure to pesticides. Pesticide are substances or combinations of substances used in many areas of agriculture and industry. They include (1) phytosanitary products (also referred to as

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Angelica Amorim Amato Department of Pharmaceutical Sciences, University of Brasilia, Brasilia, Brazil
Department of Developmental and Cell Biology, University of California, Irvine, California, USA

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Hailey Brit Wheeler Department of Developmental and Cell Biology, University of California, Irvine, California, USA

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Bruce Blumberg Department of Developmental and Cell Biology, University of California, Irvine, California, USA
Department of Pharmaceutical Sciences, University of California, Irvine, California, USA
Department of Biomedical Engineering, University of California, Irvine, California, USA

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epidemiological studies. Rodent studies reported that perinatal or early postnatal exposure to BPA ( 66 ), pesticides ( 67 ), nonylphenol ( 68 ), and PFOA ( 69 ) lead to increased weight gain during adulthood, in dose- and gender-dependent manner. Human studies

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Shane M Regnier Committee on Molecular Metabolism and Nutrition, Chicago, Illinois, USA
Pritzker School of Medicine, Chicago, Illinois, USA
University of Chicago, Chicago, Illinois, USA

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Andrew G Kirkley University of Chicago, Chicago, Illinois, USA
Committee on Molecular Pathogenesis and Molecular Medicine, Chicago, Illinois, USA

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Daniel Ruiz Committee on Molecular Metabolism and Nutrition, Chicago, Illinois, USA
University of Chicago, Chicago, Illinois, USA

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Wakanene Kamau University of Chicago, Chicago, Illinois, USA

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Qian Wu Wadsworth Center, New York Department of Health, Albany, New York, USA

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Kurunthachalam Kannan Wadsworth Center, New York Department of Health, Albany, New York, USA

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Robert M Sargis Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

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metabolic parameters, including weight gain, adiposity and glucose tolerance. Evidence that diet composition modulates the metabolic consequences of pesticide residues suggests that Environmental Protection Agency tolerance limits may need modification based

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André Marques-Pinto Serviço de Endocrinologia, Departamento de Endocrinologia, Faculdade de Medicina da Universidade do Porto, Al. Prof. Hernâni Monteiro, 4200-319 Porto, Portugal

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Davide Carvalho Serviço de Endocrinologia, Departamento de Endocrinologia, Faculdade de Medicina da Universidade do Porto, Al. Prof. Hernâni Monteiro, 4200-319 Porto, Portugal
Serviço de Endocrinologia, Departamento de Endocrinologia, Faculdade de Medicina da Universidade do Porto, Al. Prof. Hernâni Monteiro, 4200-319 Porto, Portugal

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) (12) ; plasticisers: phthalates (13) ; pesticides: atrazine (14) , cypermethrin (15) , dichlorodiphenyltrichloroethane (DDT) (16) , dieldrin (17) , methoxychlor (MXC) (16) and vinclozolin (VCZ) (18) ; and drugs: diethylstilbestrol (DES) (19

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Bilal B Mughal CNRS/UMR7221, Muséum National d’Histoire Naturelle, Sorbonne Universités, Paris, France

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Jean-Baptiste Fini CNRS/UMR7221, Muséum National d’Histoire Naturelle, Sorbonne Universités, Paris, France

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Barbara A Demeneix CNRS/UMR7221, Muséum National d’Histoire Naturelle, Sorbonne Universités, Paris, France

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perchlorate, phenols, pesticides, polychlorinated biphenyls (PCBs), poly brominated flame retardants, perfluorinated compounds (PFCs) and phthalates ( Fig. 1 ). Many of these substances are classed as persistent organic pollutants (POPs) and were banned

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Shih-Rong Lin Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan

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Shih-Fen Chen Department of Obstetrics and Gynecology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan

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Yu-Cih Yang Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan

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Chung-Y Hsu Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan

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Yu-Chih Shen Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan
Department of Psychiatry, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan
School of Medicine, Tzu Chi University, Hualien, Taiwan

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been implicated ( 4 ). Genetic association studies have identified several loci that are significantly associated with PD ( 4 ). An increased risk in individuals exposed to pesticides and those who have suffered head injuries has also been demonstrated

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Stavroula Stavrou Department of Gynecology and Obstetrics, Hospital of the LMU, Munich, Germany

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Michael Gratz Department of Gynecology and Obstetrics, Hospital of the LMU, Munich, Germany

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Eileen Tremmel Department of Gynecology and Obstetrics, Hospital of the LMU, Munich, Germany

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Christina Kuhn Department of Gynecology and Obstetrics, Hospital of the LMU, Munich, Germany

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Simone Hofmann Department of Gynecology and Obstetrics, Hospital of the LMU, Munich, Germany

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Helene Heidegger Department of Gynecology and Obstetrics, Hospital of the LMU, Munich, Germany

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Mina Peryanova Department of Gynecology and Obstetrics, Hospital of the LMU, Munich, Germany

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Kerstin Hermelink Department of Gynecology and Obstetrics, Hospital of the LMU, Munich, Germany

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Stefan Hutter Department of Gynecology and Obstetrics, Hospital of the LMU, Munich, Germany

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Bettina Toth Department of Gynaecological Endocrinology and Reproductive Medicine, Medical University Innsbruck, Innsbruck, Austria

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Doris Mayr Department of Pathology, Hospital of the LMU, Munich, Germany

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Sven Mahner Department of Gynecology and Obstetrics, Hospital of the LMU, Munich, Germany

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Udo Jeschke Department of Gynecology and Obstetrics, Hospital of the LMU, Munich, Germany

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Aurelia Vattai Department of Gynecology and Obstetrics, Hospital of the LMU, Munich, Germany

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). Bulgaroni and colleagues found that ODC upregulation may be linked to cytotrophoblast proliferation and placental repair in compensation to injuries induced by organophosphate pesticides ( 12 ). Thyroid hormone derivates function by binding to the G

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Laura Chioma Endocrinology Unit, University Pediatric Department, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy

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Carla Bizzarri Endocrinology Unit, University Pediatric Department, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy

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Martina Verzani Endocrinology Unit, University Pediatric Department, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy

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Daniela Fava Department of Pediatrics, IRCCS Istituto Giannina Gaslini, Genova, Italy
Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy

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Mariacarolina Salerno Paediatric Endocrinology Unit, Department of Translational Medical Sciences, University of Naples Federico II, Naples, Italy

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Donatella Capalbo Paediatric Endocrinology Unit, Department of Mother and Child, University Hospital Federico II, Naples, Italy

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Chiara Guzzetti Paediatric Endocrine Unit, Paediatric Hospital Microcitemico ‘A. Cao’, AO Brotzu, Cagliari, Italy

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Laura Penta Pediatric Clinic, Department of Medicine and Surgery, University of Perugia, Perugia, Italy

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Luigi Di Luigi Endocrinology Unit, Department of Movement, Human and Health Sciences, University of Rome ‘Foro Italico’, Rome, Italy

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Natascia di Iorgi Department of Pediatrics, IRCCS Istituto Giannina Gaslini, Genova, Italy
Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy

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Mohamad Maghnie Department of Pediatrics, IRCCS Istituto Giannina Gaslini, Genova, Italy
Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy

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Sandro Loche Paediatric Endocrine Unit, Paediatric Hospital Microcitemico ‘A. Cao’, AO Brotzu, Cagliari, Italy

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Marco Cappa Endocrinology Unit, University Pediatric Department, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy

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precocity after immigration from developing countries to Belgium: evidence of previous exposure to organochlorine pesticides . Human Reproduction 2001 16 1020 – 1026 . ( https://doi.org/10.1093/humrep/16.5.1020 ) 48 Vasiliu O Muttineni J Karmaus W

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Jiaxin Zhang Department of Traditional Chinese Medicine (TCM) Orthopedics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China

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Jinlan Jiang Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, China

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Yao Qin School of Public Health, Hangzhou Medical College, Hangzhou, Zhejiang, China

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Yihui Zhang Department of Traditional Chinese Medicine (TCM) Orthopedics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China

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Yungang Wu Department of Traditional Chinese Medicine (TCM) Orthopedics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China

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Huadong Xu School of Public Health, Hangzhou Medical College, Hangzhou, Zhejiang, China

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. Association between pyrethroid pesticide exposure and hearing loss in adolescents . Environmental Research 2020 187 109640. ( https://doi.org/10.1016/j.envres.2020.109640 ) 17 Xu H Mao Y Xu B Hu Y . Low-level environmental lead and cadmium

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