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Jing Hong, Wen-Yue Liu, Xiang Hu, Fei-Fei Jiang, Ze-Ru Xu, Fang Li, Fei-Xia Shen, and Hong Zhu

, hemoglobin A1c; HDL, high-density lipoprotein; LDL, low-density lipoprotein; OHA, oral hypoglycemic agent; PAD, peripheral arterial disease; QTc, heart rate-corrected QT interval; SBP, systolic blood pressure; TC, total cholesterol; TG, triglyceride

Open access

Yusaku Mori, Hiroyuki Shimizu, Hideki Kushima, Tomomi Saito, Munenori Hiromura, Michishige Terasaki, Masakazu Koshibu, Hirokazu Ohtaki, and Tsutomu Hirano

Supplementary Fig. 2). There are several limitations of the current study. First, we evaluated the vasoprotective effects of nesfatin-1 in mouse models of wire injury. Despite widespread application in studies of peripheral arterial disease ( 40 ), the present

Open access

Xiaomei Zhang, Zhangrong Xu, Xingwu Ran, and Linong Ji

://doi.org/10.2337/dc13-2432 ) 2 Criqui MH Langer RD Fronek A Feigelson HS Klauber MR McCann TJ Browner D . Mortality over a period of 10 years in patients with peripheral arterial disease . New England Journal of Medicine 1992 326 381 – 386

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Xiaoli Liu, Lanxiang Liu, Rui Wang, Xiaojiao Jia, Binbin Liu, Ning Ma, and Qiang Lu

atherosclerosis. It is an accurate, reliable, and noninvasive detection index for the early diagnosis of peripheral arterial diseases ( 6 , 7 ). Fibroblast growth factor 21 (FGF21) is a metabolic regulator that has multiple functions, such as reducing blood

Open access

E N Dudinskaya, O N Tkacheva, M V Shestakova, N V Brailova, I D Strazhesko, D U Akasheva, O Y Isaykina, N V Sharashkina, D A Kashtanova, and S A Boytsov

demonstrated a correlation between arterial stiffness and HbA1c, which is the main indicator of glucose metabolism. Our results demonstrated that the peripheral lymphocyte telomere length was shorter in patients with T2DM than in healthy individuals. A similar

Open access

Lasse Oinonen, Antti Tikkakoski, Jenni Koskela, Arttu Eräranta, Mika Kähönen, Onni Niemelä, Jukka Mustonen, and Ilkka Pörsti

the level of peripheral arterial resistance in subjects without antihypertensive medications ( 55 ). Furthermore, vasoconstriction induced by angiotensin II increases AIx, whereas vasodilatation induced by nitroglycerin reduces AIx, independent of the

Open access

Karoline Winckler, Lise Tarnow, Louise Lundby-Christensen, Thomas P Almdal, Niels Wiinberg, Pia Eiken, Trine W Boesgaard, and the CIMT trial group

: indicators of cardiovascular risk in high-risk patients. The SMART Study (Second Manifestations of ARTerial disease) . Circulation 1999 100 951 – 957 . ( doi:10.1161/01.CIR.100.9.951 ). 10 Khamdaeng T Luo J Vappou J Terdtoon P Konofagou EE

Open access

T L C Wolters, C D C C van der Heijden, N van Leeuwen, B T P Hijmans-Kersten, M G Netea, J W A Smit, D H J Thijssen, A R M M Hermus, N P Riksen, and R T Netea-Maier

, reflecting an impairment of arterial vasoprotective functioning ( 46 , 47 ). Endothelial dysfunction is considered the earliest stage of atherosclerotic disease ( 48 ), and has been reported to be present in acromegaly patients ( 3 , 6 , 33 ). Findings

Open access

Lang Qin, Xiaoming Zhu, Xiaoxia Liu, Meifang Zeng, Ran Tao, Yan Zhuang, Yiting Zhou, Zhaoyun Zhang, Yehong Yang, Yiming Li, Yongfei Wang, and Hongying Ye

been shown to increase peripheral vascular resistance and arterial stiffness thus to arterial hypertension ( 15 ). One of the mechanisms that LDL-c affects blood pressure has been shown through angiotensin 2 type 1 (AT1) receptor. Multiple studies found

Open access

Frans H H Leenen, Mordecai P Blaustein, and John M Hamlyn

, aldosterone and EO The CNS actions of Ang II, aldosterone and EO are often overlooked and/or not integrated with the peripheral actions. The relative role of these different actions is still being debated and may depend on the disease model or the extent of