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Caio Jordão Teixeira, Junia Carolina Santos-Silva, Dailson Nogueira de Souza, Alex Rafacho, Gabriel Forato Anhe and Silvana Bordin

to delivery ( 5 ). Increased glucose oxidation and glucose-stimulated insulin secretion (GSIS) by pancreatic islets are the basis of the functional adaptation of the endocrine pancreas that takes place during pregnancy ( 6 , 7 ). This functional

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K E Lines, R P Vas Nunes, M Frost, C J Yates, M Stevenson and R V Thakker

Introduction Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder, characterised by the combined occurrence of tumours of the parathyroid glands, and neuroendocrine tumours (NETs) of the pancreatic islets and anterior

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Julia Modesto Vicente, Junia Carolina Santos-Silva, Caio Jordão Teixeira, Dailson Nogueira de Souza, Jean Franciesco Vettorazzi, Fabiola Sales Furtuoso, Isabel Gouveia Adabo, Fabio Takeo Sato, Marco Aurélio Ramirez Vinolo, Everardo Magalhães Carneiro, Silvana Bordin and Gabriel Forato Anhê

elucidated if the history of pregnancy with or without lactation can affect maternal pancreatic islet physiology later in life. To address this issue, we have assessed in vivo glucose homeostasis and morphological and functional aspects of islets isolated

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Janaína Felix Braga, Daniela Ravizzoni Dartora, Natalia Alenina, Michael Bader and Robson Augusto Souza Santos

the splenic part was fixed in 10% formalin for 48 h, dehydrated in ethanol and embedded in paraffin. Tissue sections were cut 5 µm thick, with 150 µm interval between the cuts to obtain different pancreatic islets, and mounted on glass slides

Open access

Tingting Shu, Zhigang Lv, Yuchun Xie, Junming Tang and Xuhua Mao

status in the cytosol and mitochondria using the Min6 cell line, pancreatic islets and db/db mice, as well as discuss the probable mechanism by which iron toxicity influences mitochondrial function. To this end, we used db/db mice to study the effect

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Monia Cito, Silvia Pellegrini, Lorenzo Piemonti and Valeria Sordi

, Maturation of human embryonic stem cell-derived pancreatic progenitors into functional islets capable of treating pre-existing diabetes in mice . Diabetes 2012 61 2016 – 2029 . ( ) 10.2337/db11-1711 22740171 20

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Kate E Lines, Mahsa Javid, Anita A C Reed, Gerard V Walls, Mark Stevenson, Michelle Simon, Kreepa G Kooblall, Sian E Piret, Paul T Christie, Paul J Newey, Ann-Marie Mallon and Rajesh V Thakker

Introduction Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterised by the occurrence of parathyroid, pancreatic islet and anterior pituitary tumours. In addition, some patients may also develop adrenal

Open access

Gaëtan Prévost, Marie Picot, Marie-Anne Le Solliec, Arnaud Arabo, Hind Berrahmoune, Mouna El Mehdi, Saloua Cherifi, Alexandre Benani, Emmanuelle Nédélec, Françoise Gobet, Valéry Brunel, Jérôme Leprince, Hervé Lefebvre, Youssef Anouar and Nicolas Chartrel

neuropeptidergic system in the control of glucose homeostasis has been reported. It was found that 26RFa and GPR103 are expressed by the pancreatic islets as well as by various insulin-secreting cell lines ( 23 , 24 ) and that the neuropeptide prevents cell death

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Darling M Rojas-Canales, Michaela Waibel, Aurelien Forget, Daniella Penko, Jodie Nitschke, Fran J Harding, Bahman Delalat, Anton Blencowe, Thomas Loudovaris, Shane T Grey, Helen E Thomas, Thomas W H Kay, Chris J Drogemuller, Nicolas H Voelcker and Patrick T Coates

: a base, containing the microwell structures, and a lid used to enclose pancreatic islets during shipping studies. The molds were printed from temperature resistant HED525 plastic using a PolyJet printer (Objective 3D, Australia). Upon receipt, each

Open access

Sara Ullsten, Sara Bohman, Marie E Oskarsson, K Peter R Nilsson, Gunilla T Westermark and Per-Ola Carlsson

Introduction Wide heterogeneities among and within pancreatic islets have previously been identified. Beta cells vary in size, granularity, proliferation, functionality and maturation ( 1 , 2 , 3 ). Some subsets of beta cells are more