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Monia Cito, Silvia Pellegrini, Lorenzo Piemonti and Valeria Sordi

of pancreatic β cells. Unlimited pancreatic β cell source requirement fostered studies on differentiation of pluripotent stem cell (PSC) into functional insulin-secreting cells. Embryonic stem cells (ESC) and induced PSCs (iPSC) have been

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Tingting Shu, Zhigang Lv, Yuchun Xie, Junming Tang and Xuhua Mao

(Supplementary Fig. 2). The GSIS function was significantly restored compared with Ad-Gfp group ( P  < 0.01) ( Fig. 1D ). Low hepcidin expression induces iron overload in pancreatic β-cells Hepcidin plays a key role in iron homeostasis ( 28 ). Using a

Open access

Chenghao Piao, Xiaojie Wang, Shiqiao Peng, Xinyu Guo, Hui Zhao, Li He, Yan Zeng, Fan Zhang, Kewen Zhu and Yiwei Wang

recombinant mouse IL-34 (rmIL-34) on apoptosis and pancreatic β cell function. Materials and methods Study groups A cross-section study was performed at the Second Affiliated Hospital of Shenyang Medical University. A total of 120 women were

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Thozhukat Sathyapalan, Anne-Marie Coady, Eric S Kilpatrick and Stephen L Atkin

). The insulin resistance was calculated using the homeostasis model assessment (HOMA) method (HOMA-IR = (insulin × glucose)/22.5). Pancreatic beta cell function (HOMA-β) was calculated using HOMA-β = (20 × insulin)/glucose-3.5. Data are reported as mean

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Xuhua Mao, Hucheng Chen, Junmin Tang, Liangliang Wang and Tingting Shu

in addition to its role in iron regulation, hepcidin is involved in the mechanism by which gluco-toxicity impairs pancreatic β-cell function by inhibiting insulin synthesis. Furthermore, in addition to the inhibitory effects on insulin expression and

Open access

Julia Modesto Vicente, Junia Carolina Santos-Silva, Caio Jordão Teixeira, Dailson Nogueira de Souza, Jean Franciesco Vettorazzi, Fabiola Sales Furtuoso, Isabel Gouveia Adabo, Fabio Takeo Sato, Marco Aurélio Ramirez Vinolo, Everardo Magalhães Carneiro, Silvana Bordin and Gabriel Forato Anhê

). Additional prospective data revealed that exclusive breastfeeding for at least 6 months presented increased insulin sensitivity as assessed by HOMA-IR index 3 years after delivery rather than increased pancreatic β-cell function as indicated by in vivo

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Caio Jordão Teixeira, Junia Carolina Santos-Silva, Dailson Nogueira de Souza, Alex Rafacho, Gabriel Forato Anhe and Silvana Bordin

). Undisturbed pregnancies in humans and rodents are also distinguished by morphological changes in the pancreatic islets. The most evident morphological adaptations described in the human endocrine pancreas are an increase in the pancreatic β-cell fractional

Open access

K E Lines, R P Vas Nunes, M Frost, C J Yates, M Stevenson and R V Thakker

( Fig. 5A ). There are possible explanations for these findings, as follows. First, pancreatic α, β and δ cells have been reported to have the ability to transdifferentiate into different, functioning, pancreatic islet cell types under metabolic stress

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Janaína Felix Braga, Daniela Ravizzoni Dartora, Natalia Alenina, Michael Bader and Robson Augusto Souza Santos

improves pancreatic β-cell function in vitro and in vivo . Endocrinology 2016 157 4677 – 4690 . ( doi:10.1210/en.2016-1247 ) 18 Dominici FP Burghi V Muñoz MC Giani JF. Modulation of the action of insulin by angiotensin-(1-7) . Clinical Science

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L Ahlkvist, K Brown and B Ahrén

-gastrointestinal distribution, expression in pancreatic β and α cells, and involvement in islet function . Metabolism 2012 62 70 – 78 . ( doi:10.1016/j.metabol.2012.06.010 ). 38 Parker HE Habib AM Rogers GJ Gribble FM Reimann F . Nutrient-dependent secretion