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Małgorzata Fuksiewicz Department of Pathology and Laboratory Diagnostics, Laboratory of Tumor Markers, Maria Sklodowska-Curie Institute – Oncology Center, Warsaw, Poland

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Maria Kowalska Department of Pathology and Laboratory Diagnostics, Laboratory of Tumor Markers, Maria Sklodowska-Curie Institute – Oncology Center, Warsaw, Poland

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Agnieszka Kolasińska-Ćwikła Department of Oncology and Radiotherapy, Maria Sklodowska-Curie Institute – Oncology Center, Warsaw, Poland

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Jarosław B Ćwikła The Faculty of Medical Sciences, University of Warmia and Mazury, Olsztyn, Poland

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Łukasz Sawicki Department of Clinical Surgery, Maria Sklodowska-Curie Institute – Oncology Center, Warsaw, Poland

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Katarzyna Roszkowska-Purska Department of Pathology, Maria Sklodowska-Curie Institute – Oncology Center, Warsaw, Poland

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Joanna Drygiel Department of Nutrition, Maria Sklodowska-Curie Institute – Oncology Center, Warsaw, Poland

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Beata Kotowicz Department of Pathology and Laboratory Diagnostics, Laboratory of Tumor Markers, Maria Sklodowska-Curie Institute – Oncology Center, Warsaw, Poland

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digestive tract, including 59 with tumours located in the pancreas and 72 with lesions in the small intestine, caecum and appendix (midgut – the tumours originating from the central part of the archenteron) and in the colon (hindgut – tumours of the

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Malgorzata Fuksiewicz Laboratory of Tumor Markers, Department of Pathology and Laboratory Diagnostics, The Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland

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Maria Kowalska Laboratory of Tumor Markers, Department of Pathology and Laboratory Diagnostics, The Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland

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Agnieszka Kolasinska-Cwikla Department of Oncology and Radiotherapy, The Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland

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Beata Kotowicz Laboratory of Tumor Markers, Department of Pathology and Laboratory Diagnostics, The Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland

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–88 years (median age, 65 years). Lesions were located in the pancreas in 82 patients, in the small intestine in 75 patients, in the rectum in 14 patients and in the stomach in 8 patients. According to the current 2019 World Health Organization (WHO

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Gaëtan Prévost Normandie Univ, UNIROUEN, INSERM U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication (DC2N), Rouen, France
Department of Endocrinology, Diabetes and Metabolic Diseases, Normandie Univ, UNIROUEN, Rouen University Hospital, Rouen, France
Centre d’Investigation Clinique (CIC-CRB)-INSERM 1404, Rouen University Hospital, Rouen, France

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Marie Picot Normandie Univ, UNIROUEN, INSERM U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication (DC2N), Rouen, France

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Marie-Anne Le Solliec Normandie Univ, UNIROUEN, INSERM U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication (DC2N), Rouen, France

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Arnaud Arabo Normandie Univ, UNIROUEN, INSERM U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication (DC2N), Rouen, France

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Hind Berrahmoune Normandie Univ, UNIROUEN, INSERM U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication (DC2N), Rouen, France
Department of Endocrinology, Diabetes and Metabolic Diseases, Normandie Univ, UNIROUEN, Rouen University Hospital, Rouen, France
Centre d’Investigation Clinique (CIC-CRB)-INSERM 1404, Rouen University Hospital, Rouen, France

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Mouna El Mehdi Normandie Univ, UNIROUEN, INSERM U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication (DC2N), Rouen, France

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Saloua Cherifi Normandie Univ, UNIROUEN, INSERM U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication (DC2N), Rouen, France

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Alexandre Benani Center for Taste and Feeding Behaviour, CNRS (UMR6265), INRA (UMR1324), Université de Bourgogne-Franche Comté, Dijon , France

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Emmanuelle Nédélec Center for Taste and Feeding Behaviour, CNRS (UMR6265), INRA (UMR1324), Université de Bourgogne-Franche Comté, Dijon , France

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Françoise Gobet Department of Anatomopathophysiology, Normandie Univ, UNIROUEN, Rouen University Hospital, Rouen, France

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Valéry Brunel Department of Biochemistry, Normandie Univ, UNIROUEN, Rouen University Hospital, Rouen, France

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Jérôme Leprince Normandie Univ, UNIROUEN, INSERM U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication (DC2N), Rouen, France

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Hervé Lefebvre Normandie Univ, UNIROUEN, INSERM U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication (DC2N), Rouen, France
Department of Endocrinology, Diabetes and Metabolic Diseases, Normandie Univ, UNIROUEN, Rouen University Hospital, Rouen, France
Centre d’Investigation Clinique (CIC-CRB)-INSERM 1404, Rouen University Hospital, Rouen, France

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Youssef Anouar Normandie Univ, UNIROUEN, INSERM U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication (DC2N), Rouen, France

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Nicolas Chartrel Normandie Univ, UNIROUEN, INSERM U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication (DC2N), Rouen, France

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Introduction Glucose homeostasis is a crucial parameter to maintain normal body function. Control of blood glucose levels is ensured by a highly sophisticated network of various hormones released by the pancreas, intestine, liver, adipose and

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Mireille N M van Poppel Institute of Human Movement Sciences, Sport and Health, University of Graz, Graz, Austria

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Christopher J Nolan Department of Endocrinology at The Canberra Hospital and the Australian National University School of Medicine and Psychology, Canberra, ACT, Australia

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Gernot Desoye Department of Obstetrics and Gynaecology, Medical University of Graz, Graz, Austria

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Introduction Pancreas agenesis (PA) is a very rare condition that causes permanent neonatal diabetes mellitus (PNDM) and pancreatic exocrine insufficiency. It presents most commonly with neonatal hyperglycemia in small for gestational age

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Logan Mills Institute of Liver Studies, King’s College Hospital, London, UK

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Panagiotis Drymousis Department of Surgery and Cancer, Imperial College, London, UK

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Yogesh Vashist Department of General, Visceral and Thoracic Surgery, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany

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Christoph Burdelski Department of General, Visceral and Thoracic Surgery, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany

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Andreas Prachalias Department of Surgery, King’s College Hospital, London, UK

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Parthi Srinivasan Department of Surgery, King’s College Hospital, London, UK

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Krishna Menon Department of Surgery, King’s College Hospital, London, UK

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Corina Cotoi Department of Histopathology, King’s College Hospital, London, UK

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Saboor Khan Department of Surgery, University Hospitals Coventry and Warwickshire, Coventry, UK

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Judith Cave Department of Oncology, University Hospital, Southampton, UK

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Thomas Armstrong Department of Surgery, University Hospital, Southampton, UK

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Martin O Weickert Department of Endocrinology, University Hospitals Coventry and Warwickshire, Coventry, UK

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Jakob Izbicki Department of General, Visceral and Thoracic Surgery, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany

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Joerg Schrader Departments of Gastroenterology and Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

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Andreja Frilling Department of Surgery and Cancer, Imperial College, London, UK

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John K Ramage Institute of Liver Studies, King’s College Hospital, London, UK

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Raj Srirajaskanthan Institute of Liver Studies, King’s College Hospital, London, UK

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( Table 1 ). Larger tumours were significantly more likely to originate from the tail of the pancreas ( P  = 0.009) and to present with distant metastases ( P  = 0.001). Table 1 Demographics and pre-operative characteristics of patients

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Espen Nordheim Department of Transplantation Medicine, Section of Nephrology, Oslo University Hospital, Rikshospitalet, Oslo, Norway
Faculty of Medicine, University of Oslo, Oslo, Norway

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Jørn Petter Lindahl Department of Transplantation Medicine, Section of Nephrology, Oslo University Hospital, Rikshospitalet, Oslo, Norway

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Rasmus Kirkeskov Carlsen Department of Transplantation Medicine, Section of Nephrology, Oslo University Hospital, Rikshospitalet, Oslo, Norway

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Anders Åsberg Department of Transplantation Medicine, Section of Nephrology, Oslo University Hospital, Rikshospitalet, Oslo, Norway
Department of Pharmacy, University of Oslo, Oslo, Norway

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Kåre Inge Birkeland Department of Transplantation Medicine, Section of Nephrology, Oslo University Hospital, Rikshospitalet, Oslo, Norway
Faculty of Medicine, University of Oslo, Oslo, Norway

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Rune Horneland Department of Transplantation Medicine, Section of Transplantation Surgery, Oslo University Hospital, Rikshospitalet, Oslo, Norway

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Birgitte Boye Psychosomatic and CL Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital, Rikshospitalet, Oslo, Norway
Department of Behavioural Medicine, University of Oslo, Oslo, Norway

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Hanne Scholz Department of Transplantation Medicine, Section of Transplantation Surgery, Oslo University Hospital, Rikshospitalet, Oslo, Norway
Centre of Excellence-HTH, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway

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Trond Geir Jenssen Department of Transplantation Medicine, Section of Nephrology, Oslo University Hospital, Rikshospitalet, Oslo, Norway
Faculty of Medicine, University of Oslo, Oslo, Norway
Metabolic and Renal Research Group, Faculty of Health Sciences, UiT-The Arctic University of Norway, Tromsø, Norway

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Introduction Transplantation has become an established treatment option for selected patients with type 1 diabetes in many centres. Simultaneous pancreas and kidney (SPK) transplantation was offered to the first patient in history in Minnesota

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Simon Schimmack European Pancreas Center, Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany

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Yongchao Yang European Pancreas Center, Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany
Department of General Surgery, Xiangya Hospital, Central South University, Changsha, China
Department of Burns and Plastic Surgery, The Third Xiangya Hospital, Central South University, Changsha, China

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Klaus Felix European Pancreas Center, Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany

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Markus Herbst European Pancreas Center, Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany

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Yixiong Li Department of General Surgery, Xiangya Hospital, Central South University, Changsha, China

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Miriam Schenk European Pancreas Center, Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany

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Frank Bergmann Institute of Pathology, Heidelberg University, Heidelberg, Germany

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Thilo Hackert European Pancreas Center, Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany

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Oliver Strobel European Pancreas Center, Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany

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 = 14), paraffin-embedded tissue ( n  = 20) as well as serum ( n  = 76) from patients with pNEN were obtained from the Pancobank of the European Pancreas Center (EPZ/Department of Surgery, University Hospital Heidelberg; Ethical Approval Votes no. 301

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Linfei Yang Center for Medical Experiments, The Third Xiangya Hospital, Central South University, Changsha, China

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Xiao Yu Department of General Surgery, The Third Xiangya Hospital, Central South University, Changsha, China

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Yongchao Yang Department of Burns and Plastic Surgery, The Third Xiangya Hospital, Central South University, Changsha, China
European Pancreas Center, Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany

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, with the incidence rate increasing approximately 4.6-fold from 1973 (0.18 per 100,000) to 2012 (0.82 per 100,000) in the United States ( 1 , 2 , 3 ). PNEN is a clinically rare and heterogeneous disease of the pancreas with variable clinical

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Julia Modesto Vicente Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil

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Junia Carolina Santos-Silva Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil

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Caio Jordão Teixeira Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil

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Dailson Nogueira de Souza Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil

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Jean Franciesco Vettorazzi Department of Structural and Functional Biology, Institute of Biology, State University of Campinas, Campinas, Brazil

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Fabiola Sales Furtuoso Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil

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Isabel Gouveia Adabo Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil

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Fabio Takeo Sato Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, State University of Campinas, Campinas, Brazil

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Marco Aurélio Ramirez Vinolo Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, State University of Campinas, Campinas, Brazil

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Everardo Magalhães Carneiro Department of Structural and Functional Biology, Institute of Biology, State University of Campinas, Campinas, Brazil

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Silvana Bordin Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil

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Gabriel Forato Anhê Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil

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Fig. 3A. Fat pad weights were expressed as the percentage of body weight ( Table 1 ). Table 1 Adiposity and pancreas morphometric data of Virgin, L0 and L21 mice. Virgin L0 L21 Inguinal fat pad (% of body weight) 1

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Stavroula A Paschou Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, ‘Aghia Sophia’ Children’s Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece

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Nektaria Papadopoulou-Marketou Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, ‘Aghia Sophia’ Children’s Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece

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George P Chrousos Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, ‘Aghia Sophia’ Children’s Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece

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Christina Kanaka-Gantenbein Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, ‘Aghia Sophia’ Children’s Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece

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pancreas. A small percentage of affected patients (<10%) are classified as type 1B, with no evidence of autoimmunity and the pathogenesis in these cases is considered idiopathic ( 1 , 2 ). The aim of this comprehensive review is to present updated

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