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Arpna Sharma Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany

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Vijay Simha Baddela Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany

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Frank Becker Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany

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Dirk Dannenberger Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany

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Torsten Viergutz Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany

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Jens Vanselow Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany

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). Catabolism and mobilization of stored triglycerides lead to increased systemic concentrations of non-esterified fatty acids (NEFA) like palmitic acid (PA, C16:0), stearic acid (SA, C18:0), oleic acid (OA, C18:1) and of β-hydroxybutyric acid (BHBA) ( 2 ). Such

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0011
Volume/Issue:
Volume 8: Issue 5
Open access
Stephen J Winters Division of Endocrinology, Metabolism and Diabetes, University of Louisville, Louisville, Kentucky, USA

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Charles R Scoggins Division of Surgical Oncology, University of Louisville, Louisville, Kentucky, USA

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Duke Appiah Department of Public Health, Texas Tech University Health Sciences Center, Lubbock, Texas, USA

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Dushan T Ghooray Division of Endocrinology, Metabolism and Diabetes, University of Louisville, Louisville, Kentucky, USA

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higher BMI ( P < 0.001) and HOMA-IR ( P = 0.017). The concentrations of myristic, palmitic, stearic, palmitoleic, oleic and linoleic acids were all significantly higher ( P < 0.001) in those with steatosis while the level of arachidonic acid was

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-20-0401
Volume/Issue:
Volume 9: Issue 10
Open access
Shanlee M Davis Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA
eXtraOrdinarY Kids Clinic, Children's Hospital Colorado, Aurora, Colorado, USA

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Rhianna Urban Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA

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Angelo D’Alessandro Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, Colorado, USA

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Julie A Reisz Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, Colorado, USA

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Christine L Chan Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA

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Megan Kelsey Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA

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Susan Howell Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA
eXtraOrdinarY Kids Clinic, Children's Hospital Colorado, Aurora, Colorado, USA

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Nicole Tartaglia Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA
eXtraOrdinarY Kids Clinic, Children's Hospital Colorado, Aurora, Colorado, USA

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Philip Zeitler Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA
eXtraOrdinarY Kids Clinic, Children's Hospital Colorado, Aurora, Colorado, USA

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Peter Baker II Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA

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of >0.9 ( Fig. 1D ), including lysophosphatidylcholine (AUC 1.0), the medium, odd-chain fatty acids such as undecanoic acid (AUC 1.0) and nonanoic acid (AUC 0.99), the long, even-chain fatty acids such as stearic acid (AUC 0.97) and palmitic acid (AUC

Article Type:
Research Article
Collections:
Reproduction
DOI:
https://doi.org/10.1530/EC-22-0523
Volume/Issue:
Volume 12: Issue 5
Open access
Selina Mäkinen Minerva Foundation Institute for Medical Research, Helsinki, Finland
University of Helsinki, Department of Medicine, and Abdominal Center, Endocrinology, Helsinki University Central Hospital, Helsinki, Finland

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Yen H Nguyen Minerva Foundation Institute for Medical Research, Helsinki, Finland
University of Helsinki, Department of Medicine, and Abdominal Center, Endocrinology, Helsinki University Central Hospital, Helsinki, Finland

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Paulina Skrobuk Minerva Foundation Institute for Medical Research, Helsinki, Finland
University of Helsinki, Department of Medicine, and Abdominal Center, Endocrinology, Helsinki University Central Hospital, Helsinki, Finland

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Heikki A Koistinen Minerva Foundation Institute for Medical Research, Helsinki, Finland
University of Helsinki, Department of Medicine, and Abdominal Center, Endocrinology, Helsinki University Central Hospital, Helsinki, Finland

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Accuri C6 (BD Biosciences, San Jose, CA, USA). The dye was excited at 488 nm, and fluorescent emission was collected through FL3 channel. Reagents Trypsin, FBS, penicillin/streptomycin, low-glucose DMEM, l -glutamine, palmitic acid, oleic acid

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-17-0039
Volume/Issue:
Volume 6: Issue 5
Open access
Xiaonan Guo Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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Wenjing Hu Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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Xiaorui Lyu Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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Hanyuan Xu Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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Huijuan Zhu Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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Hui Pan Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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Linjie Wang Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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Hongbo Yang Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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Fengying Gong Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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with insulin resistance exhibited lower levels of palmitic acid-hydroxy stearic acid (PAHSA), a member of the FAHFA family ( 29 ). A study of animal experiments also revealed that FAHFA level was strongly decreased in high-fat diet (HFD) mice ( 28

Article Type:
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Collections:
Pituitary and Hypothalamus
DOI:
https://doi.org/10.1530/EC-23-0462
Volume/Issue:
Volume 13: Issue 5
Open access
Leanne Hodson Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford and National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), Oxford University Hospital Trusts, Oxford, UK

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Fredrik Karpe Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford and National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), Oxford University Hospital Trusts, Oxford, UK

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extraction ( 5 , 12 ). In vitro work using primary rat hepatocytes demonstrated that specific fatty acids (oleic, palmitic, stearic, palmitoleic, and eicosapentaenoic acids) were equally effective, in a concentration-dependent manner, at reducing the

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-19-0350
Volume/Issue:
Volume 8: Issue 10
Open access
Chenmin Wei Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
Department of Endocrinology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

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Zichen Zhang Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

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Qi Fu Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

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Yunqiang He Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

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Tao Yang Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

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Min Sun Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

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surface membrane ( 13 , 14 ). Most of these studies have focused on the role of K ATP channels in β cells exposed to glucotoxicity. Palmitic acid is also reported to correlate with K ATP channel trafficking and dysfunction in β cells ( 15 ). However

Article Type:
Research Article
Collections:
Metabolic Syndrome and Diabetes
DOI:
https://doi.org/10.1530/EC-22-0221
Volume/Issue:
Volume 12: Issue 1
Open access
Bo Zhu Department of Obstetrics and Gynecology, Assisted Reproduction Unit, Sir Run Run ShawHospital, Zhejiang University School of Medicine Key Laboratory of Reproductive Dysfunction Management of Zhejiang Province, Hangzhou, Zhejiang, China
Department of Gynecology and Obstetrics, Wenzhou People’s Hospital, Wenzhou Women and Children Health, Wenzhou, Zhejiang, China

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Yumei Chen Department of Gynecology and Obstetrics, Wenzhou People’s Hospital, Wenzhou Women and Children Health, Wenzhou, Zhejiang, China

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Fang Xu Department of Gynecology and Obstetrics, Wenzhou People’s Hospital, Wenzhou Women and Children Health, Wenzhou, Zhejiang, China

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Xiaolu Shen Department of Gynecology and Obstetrics, Wenzhou People’s Hospital, Wenzhou Women and Children Health, Wenzhou, Zhejiang, China

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Xuanyu Chen Department of Gynecology and Obstetrics, Wenzhou People’s Hospital, Wenzhou Women and Children Health, Wenzhou, Zhejiang, China

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Jieqiang Lv Department of Gynecology and Obstetrics, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China

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Songying Zhang Department of Obstetrics and Gynecology, Assisted Reproduction Unit, Sir Run Run ShawHospital, Zhejiang University School of Medicine Key Laboratory of Reproductive Dysfunction Management of Zhejiang Province, Hangzhou, Zhejiang, China

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) could significantly relieve ER stress and apoptosis, and improve insulin homeostasis. The ER stress is involved in the development of insulin resistance and hyperinsulinemia ( 31 ). Nonesterified fatty acids (NEFAs) derived from visceral adipose tissue

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-20-0608
Volume/Issue:
Volume 10: Issue 3
Open access
Qian Deng Graduate College of Anhui University of Chinese Medicine, Hefei, China

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Yue Zhu Graduate College of Anhui University of Chinese Medicine, Hefei, China

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Mengmeng Zhang Graduate College of Anhui University of Chinese Medicine, Hefei, China

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Aihua Fei Department of Endocrinology, The Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China

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Jiaqi Liang Graduate College of Anhui University of Chinese Medicine, Hefei, China

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Jinjin Zheng Graduate College of Anhui University of Chinese Medicine, Hefei, China

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Qingping Zhang College of Acupuncture-moxibustion and Tuina, Anhui University of Chinese Medicine, Hefei, China

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Tong Cheng Department of Geriatrics, Zhongshan Hospital, Fudan University, Shanghai, China

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Xia Ge Department of Endocrinology, The Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China

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. Palmitic acid (PA), the most common saturated long-chain fatty acid in food, can induce myocardial damage and is considered a key factor of obesity and T2DM-related cardiomyopathy development ( 64 , 65 ). A recently published study showed that the

Article Type:
Review Article
Collections:
Metabolic Syndrome and Diabetes
DOI:
https://doi.org/10.1530/EC-22-0419
Volume/Issue:
Volume 12: Issue 3
Open access
Huixing Liu Department of Cardiovascular Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China

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Daoquan Peng Department of Cardiovascular Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China

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accumulation . Journal of Experimental Biology 2009 212 1553 – 1558 . ( https://doi.org/10.1242/jeb.022210 ) 60 Fang K Wu F Chen G Dong H Li J Zhao Y Xu L Zou X Lu F . Diosgenin ameliorates palmitic acid-induced lipid accumulation via AMPK

Article Type:
Review Article
Collections:
Thyroid
DOI:
https://doi.org/10.1530/EC-21-0002
Volume/Issue:
Volume 11: Issue 2
Open access