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Xue-Lian Zhang Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China

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Xinyi Zhao Department of Physiology, School of Medicine, Jinan University, Guangzhou, China

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Yong Wu Department of Physiology, School of Medicine, Jinan University, Guangzhou, China
Department of Biomedical Engineering, Faculty of Engineering, The Hong Kong Polytechnic University, Hong Kong, China

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Wen-qing Huang Department of Transfusion Medicine, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong, China

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Jun-jiang Chen Department of Physiology, School of Medicine, Jinan University, Guangzhou, China
Department of Biomedical Engineering, Faculty of Engineering, The Hong Kong Polytechnic University, Hong Kong, China

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Peijie Hu Department of Biomedical Engineering, Faculty of Engineering, The Hong Kong Polytechnic University, Hong Kong, China

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Wei Liu Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China

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Yi-Wen Chen Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China

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Jin Hao Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China

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Rong-Rong Xie Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China

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Hsiao Chang Chan Epithelial Cell Biology Research Center, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong SAR, China

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Ye Chun Ruan Department of Biomedical Engineering, Faculty of Engineering, The Hong Kong Polytechnic University, Hong Kong, China

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Hui Chen Cell-Gene Therapy Translational Medicine Research Center, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

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Jinghui Guo Department of Physiology, School of Medicine, Jinan University, Guangzhou, China

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SDS–PAGE with each well loaded with 30 µg protein and transferred to nitrocellulose membranes. Primary antibodies, including CFTR (Catalog# 78335, Cell Signaling), p-CREB (Catalog# 91985, Cell Signaling) and β-tubulin (Catalog# 2146, Cell Signaling

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Leqi He Department of Clinical Laboratory Medicine, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China

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Xiaoying Li Department of Endocrinology, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China

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Zaoping Chen Department of Endocrinology, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China

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Wei Wang Department of Endocrinology, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China

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Kai Wang Department of Endocrinology, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China

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Xinmei Huang Department of Endocrinology, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China

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Qian Yang Department of Endocrinology, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China

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Wencai Ke Department of Clinical Laboratory Medicine, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China

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Jun Liu Department of Endocrinology, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China

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Bingbing Zha Department of Endocrinology, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China

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protein kinase A (p-PKA) and phosphorylated versions of cAMP response element-binding protein (p-CREB) were purchased from Cell Signaling Technology. The antibodies against NIS were purchased from Proteintech (Chicago, IL, USA). Reverse transcription

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Yufen Zhao College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, PR China
Key Laboratory of Animal Embryo and Development Engineering of Autonomous Region Universities, Inner Mongolia Agricultural University, Hohhot, PR China

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Erge Namei College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, PR China
Key Laboratory of Animal Embryo and Development Engineering of Autonomous Region Universities, Inner Mongolia Agricultural University, Hohhot, PR China

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Bingxue Yang College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, PR China
Key Laboratory of Animal Embryo and Development Engineering of Autonomous Region Universities, Inner Mongolia Agricultural University, Hohhot, PR China

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Xiangnan Bao Inner Mongolia Saikexing Institute of Breeding and Reproductive Biotechnology in Domestic Animal, Hohhot, PR China
National Center of Technology Innovation for Dairy Industry, Hohhot, PR China

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Wei Sun Inner Mongolia Saikexing Institute of Breeding and Reproductive Biotechnology in Domestic Animal, Hohhot, PR China

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Gerile Subudeng College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, PR China
Key Laboratory of Animal Embryo and Development Engineering of Autonomous Region Universities, Inner Mongolia Agricultural University, Hohhot, PR China

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Guifang Cao College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, PR China
Key Laboratory of Animal Embryo and Development Engineering of Autonomous Region Universities, Inner Mongolia Agricultural University, Hohhot, PR China

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Haijun Li College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, PR China
Key Laboratory of Animal Embryo and Development Engineering of Autonomous Region Universities, Inner Mongolia Agricultural University, Hohhot, PR China

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Gui Wang Animal Genetic Breeding and Reproduction Research Center, Hetao College, Bayannur, PR China

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. 3B and C ). Treatment with FSK and IBMX also significantly increased the transcript expression of Gja1 and Creb genes in ovine COCs compared to the control ( P < 0.05, Fig. 3D and E ). Figure 3 Effect of forskolin and IBMX on p-CX43

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Fan Zhang Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China

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Jian Chen Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China

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Xinyue Lin Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China

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Shiqiao Peng Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China

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Xiaohui Yu Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China

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Zhongyan Shan Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China

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Weiping Teng Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China

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relationship between cognitive impairment due to SCH and the apoptosis in cerebral cortex remains unclear. The p75 neurotrophin receptor (p75 NTR ) is an important member of the death receptor family. Although the role of the p75 NTR -mediated signal

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Erika Peverelli Endocrinology and Diabetology Unit, Diabetology and Metabolic Disease Unit, Endocrinology Unit, Unit of Human Pathology, Surgical Department, Department of Clinical Sciences and Community Health, University of Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Pad.Granelli, Via F. Sforza, 35, 20122 Milan, Italy

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Federica Ermetici Endocrinology and Diabetology Unit, Diabetology and Metabolic Disease Unit, Endocrinology Unit, Unit of Human Pathology, Surgical Department, Department of Clinical Sciences and Community Health, University of Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Pad.Granelli, Via F. Sforza, 35, 20122 Milan, Italy
Endocrinology and Diabetology Unit, Diabetology and Metabolic Disease Unit, Endocrinology Unit, Unit of Human Pathology, Surgical Department, Department of Clinical Sciences and Community Health, University of Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Pad.Granelli, Via F. Sforza, 35, 20122 Milan, Italy

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Sabrina Corbetta Endocrinology and Diabetology Unit, Diabetology and Metabolic Disease Unit, Endocrinology Unit, Unit of Human Pathology, Surgical Department, Department of Clinical Sciences and Community Health, University of Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Pad.Granelli, Via F. Sforza, 35, 20122 Milan, Italy

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Ettore Gozzini Endocrinology and Diabetology Unit, Diabetology and Metabolic Disease Unit, Endocrinology Unit, Unit of Human Pathology, Surgical Department, Department of Clinical Sciences and Community Health, University of Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Pad.Granelli, Via F. Sforza, 35, 20122 Milan, Italy

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Laura Avagliano Endocrinology and Diabetology Unit, Diabetology and Metabolic Disease Unit, Endocrinology Unit, Unit of Human Pathology, Surgical Department, Department of Clinical Sciences and Community Health, University of Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Pad.Granelli, Via F. Sforza, 35, 20122 Milan, Italy

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Marco A Zappa Endocrinology and Diabetology Unit, Diabetology and Metabolic Disease Unit, Endocrinology Unit, Unit of Human Pathology, Surgical Department, Department of Clinical Sciences and Community Health, University of Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Pad.Granelli, Via F. Sforza, 35, 20122 Milan, Italy

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Gaetano Bulfamante Endocrinology and Diabetology Unit, Diabetology and Metabolic Disease Unit, Endocrinology Unit, Unit of Human Pathology, Surgical Department, Department of Clinical Sciences and Community Health, University of Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Pad.Granelli, Via F. Sforza, 35, 20122 Milan, Italy

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Paolo Beck-Peccoz Endocrinology and Diabetology Unit, Diabetology and Metabolic Disease Unit, Endocrinology Unit, Unit of Human Pathology, Surgical Department, Department of Clinical Sciences and Community Health, University of Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Pad.Granelli, Via F. Sforza, 35, 20122 Milan, Italy

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Anna Spada Endocrinology and Diabetology Unit, Diabetology and Metabolic Disease Unit, Endocrinology Unit, Unit of Human Pathology, Surgical Department, Department of Clinical Sciences and Community Health, University of Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Pad.Granelli, Via F. Sforza, 35, 20122 Milan, Italy

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Giovanna Mantovani Endocrinology and Diabetology Unit, Diabetology and Metabolic Disease Unit, Endocrinology Unit, Unit of Human Pathology, Surgical Department, Department of Clinical Sciences and Community Health, University of Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Pad.Granelli, Via F. Sforza, 35, 20122 Milan, Italy

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subunit, is required for 3T3-L1 preadipocyte differentiation . Frontiers in Bioscience 2010 2 392 – 398 . ( doi:10.2741/e99 ). 9 Delghandi MP Johannessen M Moens U . The cAMP signalling pathway activates CREB through PKA, p38 and MSK1 in NIH

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Manon Engels Department of Paediatrics, Radboud Amalia Children’s Hospital, Radboud university medical center, Nijmegen, The Netherlands
Laboratory Medicine, Radboud Institute for Molecular Life Sciences (RIMLS), Radboud university medical center, Nijmegen, The Netherlands

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Paul N Span Radiation Oncology, Radiotherapy and OncoImmunology Laboratory, RIMLS, Radboud university medical center, Nijmegen, The Netherlands

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Rod T Mitchell MRC Centre for Reproductive Health, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Joop J T M Heuvel Laboratory Medicine, Radboud Institute for Molecular Life Sciences (RIMLS), Radboud university medical center, Nijmegen, The Netherlands

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Monica A Marijnissen-van Zanten Department of Pathology, Radboud university medical center, Nijmegen, The Netherlands

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Antonius E van Herwaarden Laboratory Medicine, Radboud Institute for Molecular Life Sciences (RIMLS), Radboud university medical center, Nijmegen, The Netherlands

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Christina A Hulsbergen-van de Kaa Department of Pathology, Radboud university medical center, Nijmegen, The Netherlands

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Egbert Oosterwijk Department of Urology, Radboud university medical center, Nijmegen, The Netherlands

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Nike M Stikkelbroeck Department of Internal Medicine, Radboud university medical center, Nijmegen, The Netherlands

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Lee B Smith MRC Centre for Reproductive Health, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Fred C G J Sweep Laboratory Medicine, Radboud Institute for Molecular Life Sciences (RIMLS), Radboud university medical center, Nijmegen, The Netherlands

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Hedi L Claahsen-van der Grinten Department of Paediatrics, Radboud Amalia Children’s Hospital, Radboud university medical center, Nijmegen, The Netherlands

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survive because of corticoid production by adrenal-like cells in the testes, which Heikinheimo ( 20 ) and Pihlajoki ( 21 ) proposed might be similar to TART cells. Interestingly, GATA genes contain cAMP response element-binding protein (CREB) sites, and

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Yao Ye Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Munich, Germany

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Aurelia Vattai Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Munich, Germany

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Nina Ditsch Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Munich, Germany

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Christina Kuhn Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Munich, Germany

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Martina Rahmeh Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Munich, Germany

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Sven Mahner Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Munich, Germany

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Myriam Ripphahn Walter Brendel Centre of Experimental Medicine, Department of Cardiovascular Physiology and Pathophysiology, Biomedical Center, Ludwig-Maximilians University of Munich, Munich, Germany

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Roland Immler Walter Brendel Centre of Experimental Medicine, Department of Cardiovascular Physiology and Pathophysiology, Biomedical Center, Ludwig-Maximilians University of Munich, Munich, Germany

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Markus Sperandio Walter Brendel Centre of Experimental Medicine, Department of Cardiovascular Physiology and Pathophysiology, Biomedical Center, Ludwig-Maximilians University of Munich, Munich, Germany

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Udo Jeschke Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Munich, Germany

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Viktoria von Schönfeldt Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Munich, Germany

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cAMP/PKA signaling inhibits the secretion of progesterone via PKA ( 50 ) and the transcription of beta-hCG via CREB ( 49 ). The activated EP3/G i1 can stimulate p-ERK1/2 and p53, which eventually enhance PAI-1 gene transcription ( 52 ). These changes

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Ling Shan Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Hospital of China Medical University, Shenyang, People’s Republic of China
Department of Endocrinology and Metabolism, People's Hospital of Liaoning Province, Shenyang, People’s Republic of China

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Yingying Zhou Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Hospital of China Medical University, Shenyang, People’s Republic of China

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Shiqiao Peng Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Hospital of China Medical University, Shenyang, People’s Republic of China

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Xinyi Wang Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Hospital of China Medical University, Shenyang, People’s Republic of China
Department of Laboratory Medical, The First Hospital of China Medical University, Shenyang, People’s Republic of China

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Zhongyan Shan Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Hospital of China Medical University, Shenyang, People’s Republic of China

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Weiping Teng Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Hospital of China Medical University, Shenyang, People’s Republic of China

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Institute of Health Guide for the Care and Use of Laboratory Animals. The rats were randomly assigned to three groups: control group (CON, n  = 35), OH group ( n  = 35) and SCH group ( n  = 35). The rats were treated by intraperitoneal (i.p.) injection of 3

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Chao Xu Key Laboratory of Aquatic Nutrition and Feed Science of Jiangsu Province, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China

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Xiang-Fei Li Key Laboratory of Aquatic Nutrition and Feed Science of Jiangsu Province, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China

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Hong-Yan Tian Department of Ocean Technology, College of Marine and Biology Engineering, Yancheng Institute of Technology, Yancheng, Province Jiangsu, China

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Hua-Juan Shi Key Laboratory of Aquatic Nutrition and Feed Science of Jiangsu Province, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China

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Ding-Dong Zhang Key Laboratory of Aquatic Nutrition and Feed Science of Jiangsu Province, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China

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Kenneth Prudence Abasubong Key Laboratory of Aquatic Nutrition and Feed Science of Jiangsu Province, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China

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Wen-Bin Liu Key Laboratory of Aquatic Nutrition and Feed Science of Jiangsu Province, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China

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analyze plasma parameters, tissue glycogen contents, related gene and protein expression levels, and hepatic enzyme activities. Tukey’s multiple test was used to compare the means at a significance level of P  < 0.05. All data are presented as the mean

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Giovanni Tulipano Unit of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy

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has been shown to affect the signalling pathway mediated by the cAMP-dependent protein kinase (PKA) activation and cAMP-responsive element-binding protein (CREB) phosphorylation in different cell types ( 12 , 27 ). In hepatocytes, biguanides suppress

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