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Department of Endocrinology, Department of Public Health, Department of Cancer Research and Molecular Medicine, Department of Medical Biochemistry, St Olavs Hospital, Trondheim University Hospital, P O Box 3250 Sluppen, N-7006 Trondheim, Norway
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Department of Endocrinology, Department of Public Health, Department of Cancer Research and Molecular Medicine, Department of Medical Biochemistry, St Olavs Hospital, Trondheim University Hospital, P O Box 3250 Sluppen, N-7006 Trondheim, Norway
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Department of Endocrinology, Department of Public Health, Department of Cancer Research and Molecular Medicine, Department of Medical Biochemistry, St Olavs Hospital, Trondheim University Hospital, P O Box 3250 Sluppen, N-7006 Trondheim, Norway
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Introduction The 1 mg overnight dexamethasone suppression test (DST) is a common initial test for endogenous Cushing's syndrome (1) . The principle of the test is that dexamethasone will suppress ACTH and cortisol secretion in healthy individuals
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Division of Diabetes, Endocrinology and Metabolism, Imperial College London, London, UK
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Division of Diabetes, Endocrinology and Metabolism, Imperial College London, London, UK
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Division of Diabetes, Endocrinology and Metabolism, Imperial College London, London, UK
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for CS including late-night salivary cortisol (LNSC), overnight dexamethasone suppression test (ODST), low-dose dexamethasone suppression test (LDDST) and 24-h urinary free cortisol (UFC) ( 1 , 2 , 3 ). A hallmark of CS is the disruption of the
Department of Medicine, Haukeland University Hospital, Bergen, Norway
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Department of Medicine, Haukeland University Hospital, Bergen, Norway
K. G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway
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K. G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway
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Department of Medicine, Haukeland University Hospital, Bergen, Norway
K. G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway
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therefore recommended that all patients with AI should be assessed for ACS. The most recent international guidelines recommend the 1 mg overnight dexamethasone suppression test (DST) to screen for ACS ( 1 ). This test is not optimal, as the DST has low
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Clinical Research Centre, Medical University of Bialystok, Bialystok, Poland
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Cushing’s syndrome ( 9 ). The definition of MACS is based on the serum cortisol values after a 1 mg overnight dexamethasone suppression test (DST); however, the cut-off values are not clearly established ( 9 ). In the European Society of Endocrinology (ESE
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participants underwent a 1 mg overnight dexamethasone suppression test (ODST) on an outpatient basis. The patients were advised to take two tablets of 0.5 mg of dexamethasone at 2300 h and the sample for cortisol was collected on the next morning between 0800
University Rehabilitation Institute Republic of Slovenia, Ljubljana, Slovenia
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Department of Endocrinology, Diabetes and Metabolic Disease, University Medical Center Ljubljana, Ljubljana, Slovenia
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Department of Endocrinology, Diabetes and Metabolic Disease, University Medical Center Ljubljana, Ljubljana, Slovenia
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Clinical Institute of Radiology, University Medical Center Ljubljana, Ljubljana, Slovenia
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Clinical Institute of Radiology, University Medical Center Ljubljana, Ljubljana, Slovenia
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Department of Endocrinology, Diabetes and Metabolic Disease, University Medical Center Ljubljana, Ljubljana, Slovenia
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Department of Endocrinology, Diabetes and Metabolic Disease, University Medical Center Ljubljana, Ljubljana, Slovenia
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to January 2011 and were characterized as NFAI. NFAI was confirmed when cortisol after 1 mg overnight dexamethasone suppression test (ODST) was < 50 nmol/L, no typical clinical signs of Cushing’s syndrome were present and pheochromocytoma and primary
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cortisol level ≥82.77 nmol/l after overnight 1-mg dexamethasone suppression test) were excluded from the study. Hormone measurement and dexamethasone suppression test The levels of ACTH, cortisol, PRA, and PAC were measured in blood samples obtained after
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. ( https://doi.org/10.1177/0004563218766566 ) 11 Vastbinder M Kuindersma M Mulder AH Schuijt MP Mudde AH . The influence of oral contraceptives on overnight 1 mg dexamethasone suppression test . Netherlands Journal of Medicine 2016 158
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Department of Pediatric Neuro-Oncology, Prinses Máxima Centrum, Utrecht, The Netherlands
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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effects. The alternative explanation for a beneficial effect of cortisol would be that cortisol-activated GR exerts different effects from dexamethasone-activated GR. Given the strong suppression of the HPA axis after dexamethasone, and the differences
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Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
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treated at 16 and 17 years after surgery. Patients who subsequently developed elevated UFC, abnormal overnight suppression test (OST; cortisol >3 µg/dL after 1 mg dexamethasone administered at midnight ( 26 )) and clinical signs of hypercortisolism were