Tingting Jia
Tingting Jia
Department of Implantology, School of Stomatology, Shandong University, Jinan, People’s Republic of China
Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Jinan, People’s Republic of China
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Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Jinan, People’s Republic of China
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Ya-nan Wang
Ya-nan Wang
Department of Implantology, School of Stomatology, Shandong University, Jinan, People’s Republic of China
Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Jinan, People’s Republic of China
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Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Jinan, People’s Republic of China
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Dongjiao Zhang
Dongjiao Zhang
Department of Implantology, School of Stomatology, Shandong University, Jinan, People’s Republic of China
Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Jinan, People’s Republic of China
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Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Jinan, People’s Republic of China
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Xin Xu
Xin Xu
Department of Implantology, School of Stomatology, Shandong University, Jinan, People’s Republic of China
Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Jinan, People’s Republic of China
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Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Jinan, People’s Republic of China
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osseointegration, which is critical for implanting, and increase the failure rate, type 2 diabetes mellitus (T2DM) is one of them ( 1 , 2 ). The pathological changes of T2DM, such as microangiopathy, immunity decline and collagen degradation, can reduce the
Yuan Liu
Yuan Liu
Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, China
Institute of Endocrine and Metabolic Diseases of Shandong University, Jinan, China
Key Laboratory of Endocrine and Metabolic Diseases, Shandong Province Medicine & Health, Jinan, China
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Institute of Endocrine and Metabolic Diseases of Shandong University, Jinan, China
Key Laboratory of Endocrine and Metabolic Diseases, Shandong Province Medicine & Health, Jinan, China
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Siyi Guo
Siyi Guo
Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, China
Institute of Endocrine and Metabolic Diseases of Shandong University, Jinan, China
Key Laboratory of Endocrine and Metabolic Diseases, Shandong Province Medicine & Health, Jinan, China
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Institute of Endocrine and Metabolic Diseases of Shandong University, Jinan, China
Key Laboratory of Endocrine and Metabolic Diseases, Shandong Province Medicine & Health, Jinan, China
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Jinsong Wu
Jinsong Wu
Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, China
Institute of Endocrine and Metabolic Diseases of Shandong University, Jinan, China
Key Laboratory of Endocrine and Metabolic Diseases, Shandong Province Medicine & Health, Jinan, China
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Institute of Endocrine and Metabolic Diseases of Shandong University, Jinan, China
Key Laboratory of Endocrine and Metabolic Diseases, Shandong Province Medicine & Health, Jinan, China
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Rongai Wang
Rongai Wang
Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, China
Health Management Center, The Second Affiliated Hospital of Zhejiang Chinese Medicine University, Zhejiang, China
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Health Management Center, The Second Affiliated Hospital of Zhejiang Chinese Medicine University, Zhejiang, China
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Jinbo Liu
Jinbo Liu
Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, China
Institute of Endocrine and Metabolic Diseases of Shandong University, Jinan, China
Key Laboratory of Endocrine and Metabolic Diseases, Shandong Province Medicine & Health, Jinan, China
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Institute of Endocrine and Metabolic Diseases of Shandong University, Jinan, China
Key Laboratory of Endocrine and Metabolic Diseases, Shandong Province Medicine & Health, Jinan, China
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Yan Liu
Yan Liu
Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, China
Institute of Endocrine and Metabolic Diseases of Shandong University, Jinan, China
Key Laboratory of Endocrine and Metabolic Diseases, Shandong Province Medicine & Health, Jinan, China
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Institute of Endocrine and Metabolic Diseases of Shandong University, Jinan, China
Key Laboratory of Endocrine and Metabolic Diseases, Shandong Province Medicine & Health, Jinan, China
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Bin Lv
Bin Lv
Department of Thyroid Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, China
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Nan Liu
Nan Liu
Department of Thyroid Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, China
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Ling Jiang
Ling Jiang
Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, China
Institute of Endocrine and Metabolic Diseases of Shandong University, Jinan, China
Key Laboratory of Endocrine and Metabolic Diseases, Shandong Province Medicine & Health, Jinan, China
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Institute of Endocrine and Metabolic Diseases of Shandong University, Jinan, China
Key Laboratory of Endocrine and Metabolic Diseases, Shandong Province Medicine & Health, Jinan, China
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Xiaoli Zhang
Xiaoli Zhang
Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, China
Institute of Endocrine and Metabolic Diseases of Shandong University, Jinan, China
Key Laboratory of Endocrine and Metabolic Diseases, Shandong Province Medicine & Health, Jinan, China
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Institute of Endocrine and Metabolic Diseases of Shandong University, Jinan, China
Key Laboratory of Endocrine and Metabolic Diseases, Shandong Province Medicine & Health, Jinan, China
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.1159/000357731 ) 35 Jiang L Zhang W Wei L Zhou Q Yang G Qian N Tang Y Gao Y Jiang X . Early effects of parathyroid hormone on vascularized bone regeneration and implant osseointegration in aged rats . Biomaterials 2018 179 15 – 28 . ( https
E M Winter
E M Winter
Leiden University Medical Center, Department of Internal Medicine, Division of Endocrinology, Center for Bone Quality, Leiden, the Netherlands
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A Ireland
A Ireland
Musculoskeletal Science and Sports Medicine Research Centre, Department of Life Sciences, Manchester Metropolitan University, Manchester, United Kingdom
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N C Butterfield
N C Butterfield
Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London, Commonwealth Building, DuCane Road, London, United Kingdom
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M Haffner-Luntzer
M Haffner-Luntzer
Institute of Orthopaedic Research and Biomechanics, University Medical Center Ulm, Ulm, Germany
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M-N Horcajada
M-N Horcajada
Nestlé Research, Department of Musculoskeletal Health, Innovation EPFL Park, Lausanne, Switzerland.
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A G Veldhuis-Vlug
A G Veldhuis-Vlug
Leiden University Medical Center, Department of Internal Medicine, Division of Endocrinology, Center for Bone Quality, Leiden, the Netherlands
Jan van Goyen Medical Center, Department of Internal Medicine, Amsterdam, the Netherlands
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Jan van Goyen Medical Center, Department of Internal Medicine, Amsterdam, the Netherlands
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L Oei
L Oei
Department of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
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Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
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G Colaianni
G Colaianni
Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy
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N Bonnet
N Bonnet
Nestlé Research, Department of Musculoskeletal Health, Innovation EPFL Park, Lausanne, Switzerland.
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−/− ) display reduced bone mass, mainly due to a bone-forming defect ( 95 ). Systemic injections of oxytocin into WT rodents increase bone mass and improve osseointegration of titanium implants ( 98 , 99 ). At the same time, oxytocin stimulates differentiation
Ann-Kristin Picke
Ann-Kristin Picke
Institute of Comparative Molecular Endocrinology, Ulm University, Ulm, Germany
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Graeme Campbell
Graeme Campbell
Institute of Biomechanics, TUHH Hamburg University of Technology, Hamburg, Germany
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Nicola Napoli
Nicola Napoli
Diabetes and Bone Network, Department Endocrinology and Diabetes, University Campus Bio-Medico of Rome, Rome, Italy
Division of Bone and Mineral Diseases, Washington University in St Louis, St Louis, Missouri, USA
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Division of Bone and Mineral Diseases, Washington University in St Louis, St Louis, Missouri, USA
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Lorenz C Hofbauer
Lorenz C Hofbauer
Department of Medicine III & Center for Healthy Aging, Technische Universität Dresden, Dresden, Germany
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Martina Rauner
Martina Rauner
Department of Medicine III & Center for Healthy Aging, Technische Universität Dresden, Dresden, Germany
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alterations and translate into a higher incidence of fractures, delayed fracture healing and delayed osseointegration. Figure 1 Effects of T2DM on bone homeostasis. T2DM negatively affects trabecular bone mass, while cortical bone mass is increased. (1
