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Ashley N Reeb Department of Otolaryngology, Head and Neck Surgery, Saint Louis University School of Medicine, Saint Louis, Missouri, USA

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Andrea Ziegler Department of Otolaryngology, Head and Neck Surgery, Saint Louis University School of Medicine, Saint Louis, Missouri, USA

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Reigh-Yi Lin Department of Otolaryngology, Head and Neck Surgery, Saint Louis University School of Medicine, Saint Louis, Missouri, USA

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microenvironment. Previously, we and other laboratories developed an orthotopic thyroid cancer model that faithfully recapitulates the clinical characteristics of advanced thyroid cancer ( 1 , 2 , 3 , 4 ). In addition, tail vein or intracardiac injection models

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-15-0114
Volume/Issue:
Volume 5: Issue 2
Open access
Qi Che Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China

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Xirong Xiao Department of Obstetrics, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China

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Jun Xu Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China

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Miao Liu Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China

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Yongning Lu Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China

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Suying Liu Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China

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Xi Dong Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China

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IL-6-neutralizing antibody (IL-6 Ab) on increased tumor proliferation and invasion was examined not only in endometrial cancer cell lines but also in cancer orthotopic xenografts mice model. For the first time, our data define a novel mechanism of E 2

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0258
Volume/Issue:
Volume 8: Issue 7
Open access
Marilena Nakaguma Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular LIM42, Disciplina de Endocrinologia, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brasil

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Fernanda A Correa Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular LIM42, Disciplina de Endocrinologia, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brasil

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Lucas S Santana Unidade de Endocrinologia Genética, Laboratório de Endocrinologia Celular e Molecular LIM25, Disciplina de Endocrinologia, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brasil

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Anna F F Benedetti Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular LIM42, Disciplina de Endocrinologia, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brasil

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Ricardo V Perez Serviço de Endocrinologia, Hospital do Servidor Público Estadual de São Paulo, Instituto de Assistência Médica ao Servidor Público Estadual (HSPE-IAMSPE), São Paulo, Brasil

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Martha K P Huayllas Hospital de Transplantes Euryclides de Jesus Zerbini, São Paulo, Brasil

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Mirta B Miras Hospital de Niños Santísima Trinidad, Cordoba, Argentina

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Mariana F A Funari Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular LIM42, Disciplina de Endocrinologia, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brasil

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Antonio M Lerario Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular LIM42, Disciplina de Endocrinologia, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brasil

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Berenice B Mendonca Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular LIM42, Disciplina de Endocrinologia, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brasil

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Luciani R S Carvalho Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular LIM42, Disciplina de Endocrinologia, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brasil

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Alexander A L Jorge Unidade de Endocrinologia Genética, Laboratório de Endocrinologia Celular e Molecular LIM25, Disciplina de Endocrinologia, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brasil

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Ivo J P Arnhold Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular LIM42, Disciplina de Endocrinologia, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brasil

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GHRHR in two patients and, as expected, both patients had IGHD with orthotopic posterior pituitary lobe. One variant was a frameshift insertion described for the first time in the present study and the other was a splicing mutation (c.57+1G>A) initially

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0085
Volume/Issue:
Volume 8: Issue 5
Open access
E T Aristizabal Prada Department of Internal Medicine IV, Campus Grosshadern, University-Hospital, Ludwig-Maximilians-University of Munich, Munich, Germany

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C J Auernhammer Department of Internal Medicine IV, Campus Grosshadern, University-Hospital, Ludwig-Maximilians-University of Munich, Munich, Germany

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of CDK4 or CDK6 were found in 19% (5/26) investigated tumour samples ( 225 ). In an orthotopic BON1 xenograft model, the multi-inhibitor ZK 304709 (CDK1, 2, 4, 7 and 9, VEGFR, PDGFR) caused significant anti-tumoural effects by induction of apoptosis

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-17-0286
Volume/Issue:
Volume 7: Issue 1
Open access
Małgorzata Więcek Department of Pediatrics and Pediatric Endocrinology, Faculty of Medical Sciences, Medical University of Silesia, Katowice, Poland

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Jakub Gawlik Student Scientific Society at the Department of Pathophysiology, Jagiellonian University Medical College, Krakow, Poland

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Zuzanna Nowak Student Scientific Society at the Department of Pathophysiology, Jagiellonian University Medical College, Krakow, Poland

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Aneta Gawlik Department of Pediatrics and Pediatric Endocrinology, Faculty of Medical Sciences, Medical University of Silesia, Katowice, Poland

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procedure involves laparoscopic removal of a part or a whole ovary, cryopreservation of the ovarian cortex, and subsequent auto-transplantation when the patient wants to pursue procreation. Transplantation can be orthotopic, which can even lead to a

Article Type:
Review Article
Collections:
Reproduction
DOI:
https://doi.org/10.1530/EC-22-0344
Volume/Issue:
Volume 11: Issue 12
Open access
Josephina G Kuiper PHARMO Institute for Drug Outcomes Research, AE Utrecht, Netherlands
Department of Public Health, Erasmus University Medical Center, Rotterdam, Netherlands

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Aline C Fenneman Department of Clinical and Experimental Vascular Medicine, Amsterdam Cardiovascular Sciences (ACS), Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands
Department of Endocrinology and Metabolism, Amsterdam Gastroenterology Endocrinology Metabolism (AGEM), Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands

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Anne H van der Spek Department of Endocrinology and Metabolism, Amsterdam Gastroenterology Endocrinology Metabolism (AGEM), Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands

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Elena Rampanelli Department of Clinical and Experimental Vascular Medicine, Amsterdam Cardiovascular Sciences (ACS), Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands

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Max Nieuwdorp Department of Clinical and Experimental Vascular Medicine, Amsterdam Cardiovascular Sciences (ACS), Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands
Department of Endocrinology and Metabolism, Amsterdam Gastroenterology Endocrinology Metabolism (AGEM), Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands

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Myrthe P P van Herk-Sukel Department of Internal Medicine and Dermatology, University Medical Center Utrecht, Utrecht, Netherlands

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Valery E P P Lemmens Department of Public Health, Erasmus University Medical Center, Rotterdam, Netherlands
Netherlands Comprehensive Cancer Organisation, Utrecht, Netherlands

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Ernst J Kuipers Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, Netherlands

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Ron M C Herings PHARMO Institute for Drug Outcomes Research, AE Utrecht, Netherlands
Department of Epidemiology and Data Science, Amsterdam UMC, Amsterdam, Netherlands

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Eric Fliers Department of Endocrinology and Metabolism, Amsterdam Gastroenterology Endocrinology Metabolism (AGEM), Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands

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lung cancer growth in an orthotopic mouse model . Endocrine-Related Cancer 2019 26 565 – 574 . ( https://doi.org/10.1530/ERC-18-0353 ) 7 Dentice M Luongo C Ambrosio R Sibilio A Casillo A Iaccarino A Troncone G Fenzi G Larsen PR

Article Type:
Research Article
Collections:
Hormones and Cancer
DOI:
https://doi.org/10.1530/EC-21-0463
Volume/Issue:
Volume 11: Issue 1
Open access
Ashley K Clift Department of Surgery and Cancer, Imperial College London, London, UK

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Omar Faiz Department of Surgery, St Mark’s Hospital, London, UK

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Robert Goldin Centre for Pathology, Imperial College London, London, UK

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John Martin Department of Gastroenterology, Imperial College London, London, UK

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Harpreet Wasan Department of Surgery and Cancer, Imperial College London, London, UK

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Marc-Olaf Liedke Department of Surgery, Westkuesten Klinikum Heide, Heide, Germany

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Erik Schloericke Department of Surgery, Westkuesten Klinikum Heide, Heide, Germany

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Anna Malczewska Department of Surgery and Cancer, Imperial College London, London, UK
Department of Pathophysiology and Endocrinology, Medical University of Silesia, Katowice, Poland

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Guido Rindi Institute of Anatomic Pathology, Universita Cattolica del Sacro Cuore, Rome, Italy

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Mark Kidd Wren Laboratories, Branford, Connecticut, USA

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Irvin M Modlin Emeritus Professor Gastrointestinal Surgery, School of Medicine, Yale University, New Haven, Connecticut, USA

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Andrea Frilling Department of Surgery and Cancer, Imperial College London, London, UK

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underwent resection of the primary tumour prior to orthotopic liver transplantation. Another patient with a multifocal SB NET with extensive mesenteric disease underwent multivisceral transplantation after neo-adjuvant PRRT ( 30 ). There was no mortality in

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-16-0114
Volume/Issue:
Volume 6: Issue 2
Open access
Serena Martinelli Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy

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Mario Maggi Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy

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Elena Rapizzi Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy

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under the skin (ectopic) or into the organ of tumour origin (orthotopic) using immunodeficient rodents, such as athymic nude mice or severely compromised immunodeficient (SCID) mice. Regarding the engrafted mice, Giubellino et al . developed a MTT

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-20-0472
Volume/Issue:
Volume 9: Issue 12
Open access
D A Dart Cardiff China Medical Research Collaborative, Cardiff University School of Medicine, Cardiff, Wales, UK
Imperial College London, London, UK

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K Ashelford Division of Cancer and Genetics, Wales Gene Park, School of Medicine, Cardiff University, Cardiff, Wales, UK

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W G Jiang Cardiff China Medical Research Collaborative, Cardiff University School of Medicine, Cardiff, Wales, UK

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significance. Data are given in Supplementary Fig. 3B. The AR UTR was also detected and was increased ( P  = 0.03) in a study by Knuuttila et al . (GSE95413) in orthotopically grown castration resistant VCaP xenografts treated with enzalutamide

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0340
Volume/Issue:
Volume 9: Issue 1
Open access
Marra Jai Aghajani Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia
School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia

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Tao Yang School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
Saint Vincent’s Clinical School, UNSW Sydney, Sydney, Australia
SydPath, Saint Vincent’s Hospital, Sydney, Australia

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Ulf Schmitz Computational BioMedicine Laboratory Centenary Institute, The University of Sydney, Camperdown, New South Wales, Australia
Gene & Stem Cell Therapy Program Centenary Institute, The University of Sydney, Camperdown, New South Wales, Australia
Faculty of Medicine & Health, The University of Sydney, Camperdown, New South Wales, Australia

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Alexander James Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia

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Charles Eugenio McCafferty Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia
School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia

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Paul de Souza Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia
School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
School of Medicine, University of Wollongong, New South Wales, Australia

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Navin Niles Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia
School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
Department of Head & Neck Surgery, Liverpool Hospital, Liverpool, New South Wales, Australia
Department of Clinical Medicine, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia

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Tara L Roberts Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia
School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
South West Sydney Clinical School, UNSW Sydney, Sydney, Australia

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promoted GBM development and invasion in orthotopic GBM rat models. Following 48 h of IFN-γ treatment, we also detected a significant increase in PD-L1 expression in all thyroid cancer cell lines examined. This rise in PD-L1 was accompanied by phenotypic

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-20-0268
Volume/Issue:
Volume 9: Issue 10
Open access